succinic acid mono-vinylamide | 44912-10-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: succinic acid mono-vinylamide
• 英文别名: Bernsteinsaeure-mono-vinylamid；Bernsteinsaeure-monovinylamid；N-Vinylamidobernsteinsaeure；4-(ethenylamino)-4-oxobutanoic acid
• CAS: 44912-10-9
• 化学式: C₆H₉NO₃
• mdl: MFCD19217521
• 分子量: 143.142
• InChiKey: RRSZVVDCGQSKIK-UHFFFAOYSA-N

物化性质

• 熔点：
  93-94 °C(Solv: ethyl ether (60-29-7))
• 沸点：
  395.7±34.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  succinic acid mono-vinylamide 生成 N-ethyl-succinamic acid
  参考文献：
  名称：

  Notes- Syntheses of N-Vinyl-secondary-amic Acids

  摘要：

  DOI：

  10.1021/jo01085a612

文献信息

• [EN] IMMUNOPHILIN BINDING AGENTS AND USES THEREOF<br/>[FR] AGENTS DE LIAISON À L'IMMUNOPHILINE ET LEURS UTILISATIONS
  申请人：UNIV CALIFORNIA

  公开号：WO2020163594A1

  公开（公告）日：2020-08-13

  Described herein, inter alia, are immunophilin binding compounds and methods of treating CNS diseases, including co-administering outside the CNS of a subject an anti-CNS disease drug and a compound described herein.

  本文描述了免疫蛋白结合化合物以及治疗中枢神经系统疾病的方法，包括在主体的中枢神经系统外联合给予一种抗中枢神经系统疾病药物和本文描述的化合物。
• Salts of menantine and cox-inhibitors and their crystal form in the treatment of pain
  申请人：Laboratorios Del. Dr. Esteve, S.A.

  公开号：EP2098500A1

  公开（公告）日：2009-09-09

  The present invention relates to salts of Memantine and COX-INHIBITORs, their crystal form, the processes for preparation of the same and their uses as medicaments, more particularly for the treatment of pain.

  本发明涉及美金替林和COX-抑制剂的盐，它们的晶体形式，制备过程以及它们作为药物的用途，尤其用于治疗疼痛。
• SALTS OF MEMANTINE AND COX-INHIBITORS AND THEIR CRYSTAL FORM IN THE TREATMENT OF PAIN
  申请人：Buschmann Helmut Heinrich

  公开号：US20110105443A1

  公开（公告）日：2011-05-05

  The present invention relates to salts of Memantine and COX-INHIBITORs, their crystal form, the processes for preparation of the same and their uses for the treatment of various disorders, including pain.

  本发明涉及美金刚烷盐和COX抑制剂的盐，它们的晶体形态，制备方法以及它们用于治疗各种疾病，包括疼痛的用途。
• Ink, and ink-jet recording method and apparatus employing the same
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP0618278A2

  公开（公告）日：1994-10-05

  An ink for ink-jet recording is provided which contains a coloring material and an aqueous liquid medium for solving or dispersing the coloring material, the liquid medium having a lower critical consolute temperature (Tc) to cause phase separation at a temperature in the range of from 40 to 100°C. Ink-jet recording method and an ink-jet recording apparatus employing the above ink are also provided.

  提供了一种用于喷墨记录的墨水，该墨水包含着色材料和用于溶解或分散着色材料的水性液体介质，液体介质具有较低的临界固相温度（Tc），可在 40 至 100°C 的温度范围内导致相分离。还提供了采用上述墨水的喷墨记录方法和喷墨记录装置。
• Polymer modification
  申请人：PolyMASC Pharmaceuticals plc

  公开号：EP1026171A1

  公开（公告）日：2000-08-09

  A process for producing an adduct of a polymer and a target material which process comprises the steps of (a) reacting tresyl chloride with a polymer of formula (II)         (C)c POL - Gg     (II) wherein POL is a polymer moiety of valency c+g, C is a capping group and c is zero or a positive number and G is a terminal hydroxyl group reactive with the compound of formula (I) and g is a positive number so as to form a sulphonate ester-activated polymer of formula (III)         (C)c POL - (tresyl)g     (III) wherein C, POL, -AM, c and g are as defined above (b) reacting the activated polymer of formula (III) with the target material and (c) recovering the adduct of the polymer and the target material, in which process: (i) the polymer of formula (II) is dry as determined by benzene distillation, and (ii) the reaction of the tresyl chloride with the polymer of formula (II) is conducted in an organic solvent which is inert to the reagents and to the product of formula (III) and is anhydrous as obtainable using molecular sieves of 0.3nm; (iii) the reaction of the tresyl chloride with the polymer of formula (II) is conducted in a reaction vessel from which water is excluded; (iv) the activated polymer of formula (III) so produced is recovered and either used directly in step (b) or stored, prior to use in step (b), in the presence of a desiccating agent more hygroscopic than the product of formula (III); and v) the reaction of the activated polymer with the target material is conducted in a non-denaturing medium and non-denaturing temperature with respect to the target material.

  一种生产聚合物和目标材料加合物的工艺，该工艺包括以下步骤 (a) 使甲酰氯与式 (II) 的聚合物反应 (C)c POL - Gg (II) 其中 POL 是化合价为 c+g 的聚合物分子、 C 是封端基团，c 为零或正数，以及 G 是与式 (I) 化合物反应的末端羟基，g 为正数 从而形成 式（III）的磺酸酯活性聚合物 (C)c POL - (甲苯基)g (III) 其中 C、POL、-AM、c 和 g 如上定义 (b) 使式(III)的活化聚合物与目标材料反应，并 (c) 回收聚合物与目标材料的加合物、 在该过程中 (i) 根据苯蒸馏法测定，式（II）聚合物是干的，以及 (ii) 甲酰氯与式(II)聚合物的反应在对试剂和式(III)产物惰性且无水的有机溶剂中进行，该有机溶剂可使用 0.3nm 的分子筛获得； (iii) 三氯甲烷与式(II)聚合物的反应是在不含水的反应容器中进行的； (iv) 如此制得的式(III)活化聚合物被回收并直接用于步骤(b)，或在用于步骤(b)之前， 在比式(III)产物吸湿性更强的干燥剂存在下储存；以及 v) 活性聚合物与目标材料的反应是在非变性介质和相对于目标材料的非变性温度下进行的。