Methyl 3-ethyl-4-pyridineacetate | 35167-59-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Methyl 3-ethyl-4-pyridineacetate
• 英文别名: 3-Ethyl-4-pyridinessigsaeure-methylester；(3-ethyl-pyridin-4-yl)-acetic acid methyl ester；Methyl 2-(3-ethylpyridin-4-yl)acetate
• CAS: 35167-59-0
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: MRFZHLXHHPYLKO-UHFFFAOYSA-N

物化性质

• 沸点：
  268.2±25.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Methyl 3-ethyl-4-pyridineacetate 在 双氧水 、 溶剂黄146 作用下， 生成 (3-Ethyl-1-oxy-pyridin-4-yl)-acetic acid methyl ester
  参考文献：
  名称：

  Suzuki, Toshio; Sato, Etsuko; Goto, Kozo, Heterocycles, 1980, vol. 14, # 4, p. 433 - 437

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙基-4-甲基吡啶 、 碳酸二甲酯 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以75%的产率得到Methyl 3-ethyl-4-pyridineacetate
  参考文献：
  名称：

  Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters

  摘要：

  A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00615-7

文献信息

• Total Synthesis of Uleine-Type and Strychnos Alkaloids through a Common Intermediate
  作者：Jordi Gracia、Nuria Casamitjana、Josep Bonjoch、Joan Bosch

  DOI：10.1021/jo00093a028

  日期：1994.7

  A stereoselective total synthesis of the alkaloids of the uleine group, dasycarpidone, dasycarpidol, and nordasycarpidone, has been accomplished from the tetracyclic intermediate 1, which has been prepared by two alternative routes, either by Fischer indolization of 2-azabicyclo[3.3.1]nonanone 9 or, more efficiently, by stereocontrolled cyclization of 2-[(2-cyano-3-ethyl-4-piperidyl)methyl]i 24a and 24b. From the same tetracyclic intermediate 1, the Strychnos alkaloid tubotaiwine was also synthesized, the key step being the construction of the quaternary spiranic center by cyclization of a thionium ion upon the indole beta-position.
• CHIRAL DESIGN
  申请人：WAVE LIFE SCIENCES LTD.

  公开号：US20170037399A1

  公开（公告）日：2017-02-09

  The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.
• Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters
  作者：Richard Frenette、Marc Blouin、Christine Brideau、Nathalie Chauret、Yves Ducharme、Richard W. Friesen、Pierre Hamel、Tom R. Jones、France Laliberté、Chun Li、Paul Masson、Malia McAuliffe、Yves Girard

  DOI：10.1016/s0960-894x(02)00615-7

  日期：2002.10

  A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Suzuki, Toshio; Sato, Etsuko; Goto, Kozo, Heterocycles, 1980, vol. 14, # 4, p. 433 - 437
  作者：Suzuki, Toshio、Sato, Etsuko、Goto, Kozo、Unno, Katsuo、Kametani, Tetsuji

  DOI：——

  日期：——