ethoxymethyl 4-methoxybenzoate | 1380825-76-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethoxymethyl 4-methoxybenzoate
• 英文别名: Ethoxymethyl 4-methoxybenzoate
• CAS: 1380825-76-2
• 化学式: C₁₁H₁₄O₄
• 分子量: 210.23
• InChiKey: ULZYGUIFJKUGOK-UHFFFAOYSA-N

物化性质

• 沸点：
  315.9±22.0 °C(Predicted)
• 密度：
  1.102±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  乙二醇二乙醚 、 大茴香酸 在 copper(I) oxide 、 氧气 、 potassium carbonate 作用下， 110.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以43%的产率得到ethoxymethyl 4-methoxybenzoate
  参考文献：
  名称：

  Unexpected Copper-Catalyzed Aerobic Oxidative Cleavage of C(sp³)–C(sp³) Bond of Glycol Ethers

  摘要：

  An unexpected Cu-catalyzed oxidative cleavage of the C(sp(3))-C(sp(3)) bond in glycol ethers by using air or molecular oxygen as the terminal stoichiometric oxidant is demonstrated. As a result, the corresponding alpha-acyloxy ethers and formates of 1,2-ethanediol are formed by direct coupling of carboxylic acids and aldehydes with glycol ethers under the reaction conditions. This method represents the first example of Cu-catalyzed aerobic cleavage of saturated C-C bond in ethers.

  DOI：

  10.1021/ol301220s

文献信息

• US9500947B2
  申请人：——

  公开号：US9500947B2

  公开（公告）日：2016-11-22
• Unexpected Copper-Catalyzed Aerobic Oxidative Cleavage of C(sp³)–C(sp³) Bond of Glycol Ethers
  作者：Zhong-Quan Liu、Lixing Zhao、Xiaojie Shang、Zili Cui

  DOI：10.1021/ol301220s

  日期：2012.6.15

  An unexpected Cu-catalyzed oxidative cleavage of the C(sp(3))-C(sp(3)) bond in glycol ethers by using air or molecular oxygen as the terminal stoichiometric oxidant is demonstrated. As a result, the corresponding alpha-acyloxy ethers and formates of 1,2-ethanediol are formed by direct coupling of carboxylic acids and aldehydes with glycol ethers under the reaction conditions. This method represents the first example of Cu-catalyzed aerobic cleavage of saturated C-C bond in ethers.