2-(β-hydroxyethyl)benzaldehyde | 75802-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(β-hydroxyethyl)benzaldehyde
• 英文别名: 2-(2-hydroxyethyl)benzaldehyde；2-<2-Hydroxy-aethyl>-benzaldehyd；2-(2-Hydroxy-aethyl)-benzaldehyd
• CAS: 75802-18-5
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: YEAQCTYLLMRFGA-UHFFFAOYSA-N

物化性质

• 熔点：
  75 °C
• 沸点：
  281.3±15.0 °C(Predicted)
• 密度：
  1.142±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(β-hydroxyethyl)benzaldehyde 以 水 为溶剂， 生成 1-羟基异苯并二氢吡喃
  参考文献：
  名称：

  Kinetic study of the reversible formation of cyclic hemiacetals from 2-(hydroxymethyl)benzaldehyde and 2-(.beta.-hydroxyethyl)benzaldehyde

  摘要：

  DOI：

  10.1021/jo00318a015
• 作为产物：
  描述：

  1-羟基异苯并二氢吡喃 以 水 为溶剂， 生成 2-(β-hydroxyethyl)benzaldehyde
  参考文献：
  名称：

  Kinetic study of the reversible formation of cyclic hemiacetals from 2-(hydroxymethyl)benzaldehyde and 2-(.beta.-hydroxyethyl)benzaldehyde

  摘要：

  DOI：

  10.1021/jo00318a015

文献信息

• p-Toluenesulfonic Acid-Catalyzed Reaction of Phthalaldehydic Acids with Difluoroenoxysilanes: Access to 3-Difluoroalkyl Phthalides
  作者：Jianguo Yang、Jun Ren、Saimei Liu、Yan Li、Feiyi Wang、Chao Ma、Guichun Yang

  DOI：10.1055/a-1581-2408

  日期：2022.1

  A convenient approach for the synthesis of 3-difluoroalkyl phthalides has been developed from phthalaldehydic acids and difluoroenoxysilanes by using relatively inexpensive p-toluenesulfonic acid monohydrate (PTSA) as a catalyst. A series of 3-difluoroalkyl phthalides and cyclic difluoroalkyl ethers were obtained in up to 99% yield. The products obtained could be readily converted into difluoroalkyl

  通过使用相对便宜的对甲苯磺酸一水合物 (PTSA) 作为催化剂，从邻苯二甲酸和二氟烯氧基硅烷开发了一种合成 3-二氟烷基苯酞的简便方法。以高达 99% 的产率获得了一系列 3-二氟烷基苯酞和环状二氟烷基醚。得到的产物可以通过简单的修饰很容易地转化为二氟烷基苯酞衍生物。
• Endo-Selective Pd-Catalyzed Silyl Methyl Heck Reaction
  作者：Marvin Parasram、Viktor O. Iaroshenko、Vladimir Gevorgyan

  DOI：10.1021/ja5104525

  日期：2014.12.31

  A palladium (Pd)-catalyzed endo-selective Heck reaction of iodomethylsilyl ethers of phenols and aliphatic alkenols has been developed. Mechanistic studies reveal that this silyl methyl Heck reaction operates via a hybrid Pd-radical process and that the silicon atom is crucial for the observed endo selectivity. The obtained allylic silyloxycycles were further oxidized into (Z)-alkenyldiols.

  已开发出钯 (Pd) 催化的苯酚和脂肪族烯醇的碘甲基甲硅烷基醚的内选择性 Heck 反应。机理研究表明，这种甲硅烷基甲基 Heck 反应通过混合 Pd 自由基过程进行，并且硅原子对于观察到的内向选择性至关重要。得到的烯丙基甲硅烷氧基环进一步氧化成(Z)-烯基二醇。
• Reactivity of isocoumarins. III. Reaction of 1-ethoxyisochroman with benzylamines.
  作者：MASATOSHI YAMATO、TADATAKA ISHIKAWA、TOSHIO KOBAYASHI

  DOI：10.1248/cpb.29.720

  日期：——

  As a part of our studies on the reactions of 1-ethoxyisochroman (1) with nucleophilic reagents, the reaction of 1 with benzylamines was examined. Heating of 1 with benzylamine or its derivatives having an electron-releasing or-attracting group at the 4-position gave 1-benzylaminoisochroman (2) or the corresponding 1-(4-substituted benzylamino) isochromans (6 and 7). Pyrolysis of 2, 6, and 7 gave 4-benzylisoquinoline (3) and 4-(4-substituted benzyl)-isoquinolines (8 and 9), respectively. Compound 3 was also obtained by heating 2-(2-hydroxyethyl) benzaldehyde with benzylamine, or by heating 2-vinylbenzylidenebenzylamine (4), while the reaction of 1 with N-methylbenzylamine afforded 1-(N-methylbenzylamino) isochroman (5) and did not give the 4-benzylisoquinoline derivative at all. The reaction mechanism giving 4-benzylisoquinolines is proposed to be as shown in Chart 3.

  作为 1-乙氧基异色满（1）与亲核试剂反应研究的一部分，我们还研究了 1 与苄胺的反应。将 1 与苄胺或其在 4 位具有释放或吸引电子基团的衍生物加热，可得到 1-苄氨基异色满（2）或相应的 1-（4-取代苄氨基）异色满（6 和 7）。热解 2、6 和 7 分别得到 4-苄基异喹啉（3）和 4-（4-取代苄基）-异喹啉（8 和 9）。化合物 3 还可以通过加热 2-（2-羟乙基）苯甲醛与苄胺或加热 2-乙烯基亚苄基苄胺 (4) 而得到，而 1 与 N-甲基苄胺反应得到 1-（N-甲基苄基氨基）异色原 (5)，根本没有得到 4-苄基异喹啉衍生物。产生 4-苄基异喹啉的反应机理如图 3 所示。
• CYCLIC COMPOUND, PRODUCTION PROCESS THEREOF, RADIATION-SENSITIVE COMPOSITION AND RESIST PATTERN FORMATION METHOD
  申请人：Takasuka Masaaki

  公开号：US20120282546A1

  公开（公告）日：2012-11-08

  Disclosed are: a cyclic compound which has high solubility in a safe solvent, is highly sensitive, enables the formation of a resist pattern having a good shape, and rarely causes resist pattern collapse; a process for producing the cyclic compound; a radiation-sensitive composition containing the cyclic compound; and a resist pattern formation method using the composition. Specifically disclosed are: a cyclic compound having a specific structure; a process for producing the cyclic compound; a radiation-sensitive composition containing the compound; and a resist pattern formation method using the composition.

  本发明涉及一种具有高溶解度、高灵敏度、能够形成良好形状的抗蚀图案，且很少引起抗蚀图案崩塌的环状化合物；一种制备该环状化合物的方法；一种含有该环状化合物的辐射敏感组合物；以及使用该组合物的抗蚀图案形成方法。具体揭示了一种具有特定结构的环状化合物，制备该环状化合物的方法，含有该化合物的辐射敏感组合物以及使用该组合物的抗蚀图案形成方法。
• BILIRUBIN ANTIGEN, MONOCLONAL ANTIBODY THEREFOR, PROCESS FOR THEIR PREPARATION, AND THEIR USE
  申请人：KUKITA, Takeshi

  公开号：EP0307476A1

  公开（公告）日：1989-03-22

  A novel bilirubin antigen capable of functioning as an antigen which does not undergo decomposition in vivo. This antigen has a structure wherein a protein is bound to the methylene group of the outer vinyl group present in the outermost ring of bilirubin through a spacer or to at least one carboxyl group. A monoclonal antibody capable of recognizing the bilirubin antigen can be obtained from hybridoma cells prepared by cell fusion between antibody-yielding cells obtained by immunizing with the bilirubin antigen and tumor cells capable of division and growth in a culture medium. This monoclonal antibody can recognize bilirubins present in vivo without decomposing their structures, and hence it enables direct qualitative and analyses of bilirubins.

  一种新型胆红素抗原，能够作为一种在体内不分解的抗原发挥作用。这种抗原的结构是：蛋白质通过一个间隔物与胆红素最外层环中乙烯基外层的亚甲基或至少一个羧基结合。能够识别胆红素抗原的单克隆抗体可以从杂交瘤细胞中获得，杂交瘤细胞是通过免疫胆红素抗原获得的产生抗体的细胞与能够在培养基中分裂和生长的肿瘤细胞进行细胞融合而制备的。这种单克隆抗体可以识别体内存在的胆红素，而不会分解其结构，因此可以直接对胆红素进行定性和分析。