2-氯丙烷-2-D1 | 53778-42-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 2-氯丙烷-2-D1
• 英文名称: 2-chloro-2-deuterio-propane
• 英文别名: 2-Chlor-2-deuterio-propan；2-chloro-propane-2-d；d1-Isopropylchlorid；2-Chlor-2-D-propan；2-D-2-Chlor-propan；2-Chloropropane-2-D1；2-chloro-2-deuteriopropane
• CAS: 53778-42-0
• 化学式: C₃H₇Cl
• 分子量: 79.5336
• InChiKey: ULYZAYCEDJDHCC-WFVSFCRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (trimethylstannyl)lithium 、 2-氯丙烷-2-D1 以 四氢呋喃 为溶剂， 生成 trimethyl(propan-2-yl-2-d)stannane
  参考文献：
  名称：

  Interet de la deuteriation des molecules organostanniques en rmn de 119Sn

  摘要：

  DOI：

  10.1016/s0022-328x(00)85700-9
• 作为产物：
  描述：

  2-丙醇-2-d1 在 盐酸 、 水 、 zinc(II) chloride 作用下， 生成 2-氯丙烷-2-D1
  参考文献：
  名称：

  Laparoscopic presacral neurectomy ‐ retrospective series

  摘要：

  摘要：我们对一名外科医生（AL）的医疗记录进行了回顾性审计。确定了所有因严重中线痛经而接受腹腔镜骶前神经切除术的患者。对术前症状、临床发现和手术记录的细节进行了研究。根据疼痛量表评估痛经的改善情况。12 名患者接受了腹腔镜骶前神经切除术。八名患者的症状明显改善，另有两名患者的症状轻微改善。两名患者的症状没有得到任何改善。我们认为，腹腔镜骶前神经切除术的作用应仅限于对药物治疗无效的严重中线痛经患者。它可以作为腹腔镜子宫内膜异位症切除术或粘连溶解术的辅助手术。

  DOI：

  10.1111/j.1479-828x.2001.tb01208.x

文献信息

• Photooxidation of Alkyl 4-Nitrophenyl Sulfides and Sulfoxides. Observation of Oxidative C-S Bond Cleavage and Rearrangement Reactions
  作者：Daniel J. Pasto、Francois Cottard、Laurent Jumelle

  DOI：10.1021/ja00099a015

  日期：1994.10

  Alkyl 4-nitrophenyl sulfides and sulfoxides undergo a self-photoinduced, singlet oxygen oxidation to produce a variety of products, including sulfonates and carbonyl compounds formed by the oxidative cleavage of the C-S bond of the sulfides and sulfoxides. Structural rearrangements are observed in the resulting carbonyl compounds formed in the oxidative cleavage of the C-S bond in the tert-amyl and 2-phenylethyl sulfides. An overall mechanism is proposed which involves the formation of peroxysulfoxides and peroxysulfones which undergo heterolytic C-S bond cleavage to form ion pairs which recombine to form persulfenates or persulfinates which then undergo photo- and/or thermally-induced homolytic O-O bond cleavage to form alkoxy and sulfinyl or sulfonyl radicals. The alkoxy radicals undergo beta-scission, disproportionation, or recombination with the sulfonyl radical to form the observed products. These C-S oxidative cleavage reactions have only been rarely observed in the earlier studies on the singlet oxygen oxidation studies of dialkyl sulfides, and are attributed, in part, to the presence of the 4-nitro group on the aromatic ring which greatly affects the susceptibility of the sulfur atom of the sulfides and sulfoxides toward nucleophilic attack, and on the reactivity of the peroxysulfoxides and peroxysulfones toward heterolytic cleavage of the O-S bond.