8-Amino-2-[(tert-butyldiphenylsilyl)oxy]-naphthalene | 254108-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-Amino-2-[(tert-butyldiphenylsilyl)oxy]-naphthalene
• 英文别名: 7-[tert-butyl(diphenyl)silyl]oxynaphthalen-1-amine
• CAS: 254108-47-9
• 化学式: C₂₆H₂₇NOSi
• 分子量: 397.592
• InChiKey: XMUKTGVSGFKVTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.36
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Amino-2-[(tert-butyldiphenylsilyl)oxy]-naphthalene 在 盐酸 、 四丁基氟化铵 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 sodium cyanoborohydride 、 caesium carbonate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 (20R)-19,20,21,22-Tetrahydro-20-methyl-19-oxo-5H-12,14-etheno-6,10-metheno-18H-benz[d]imidazo[4,3-k][1,6,9,12]oxatriazacyclooctadecine-9-carbonitrile
  参考文献：
  名称：

  Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase

  摘要：

  A series of amino acid-based linkers was used to investigate the effects of various substituents upon the potency, pharmacokinetic properties, and conformation of macrocyclic farnesyl-protein transferase inhibitors (FTIs). As a result of the studies described herein, highly potent FTIs with improved pharmacokinetic profiles have been identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00340-7
• 作为产物：
  描述：

  1-氨基-7-萘酚 在 咪唑 、 盐酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 8-Amino-2-[(tert-butyldiphenylsilyl)oxy]-naphthalene
  参考文献：
  名称：

  Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase

  摘要：

  A series of amino acid-based linkers was used to investigate the effects of various substituents upon the potency, pharmacokinetic properties, and conformation of macrocyclic farnesyl-protein transferase inhibitors (FTIs). As a result of the studies described herein, highly potent FTIs with improved pharmacokinetic profiles have been identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00340-7

文献信息

• Inhibitors of prenyl-protein transferase
  申请人：Merck & Co., Inc.

  公开号：US06562823B1

  公开（公告）日：2003-05-13

  The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

  本发明涉及一种含有肽类似物哌嗪的大环化合物，该化合物能抑制异戊二烯-蛋白转移酶以及致癌基因蛋白Ras的异戊二烯化作用。该发明还涉及含有本发明化合物的化疗组合物以及抑制异戊二烯-蛋白转移酶和致癌基因蛋白Ras的方法。
• Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase
  作者：Douglas C Beshore、Ian M Bell、Christopher J Dinsmore、Carl F Homnick、J.Christopher Culberson、Ronald G Robinson、Christine Fernandes、Eileen S Walsh、Marc T Abrams、Hema G Bhimnathwala、Joseph P Davide、Michelle S Ellis-Hutchings、Hans A Huber、Kenneth S Koblan、Carolyn A Buser、Nancy E Kohl、Robert B Lobell、I-Wu Chen、Debra A McLoughlin、Timothy V Olah、Samuel L Graham、George D Hartman、Theresa M Williams

  DOI：10.1016/s0960-894x(01)00340-7

  日期：2001.7

  A series of amino acid-based linkers was used to investigate the effects of various substituents upon the potency, pharmacokinetic properties, and conformation of macrocyclic farnesyl-protein transferase inhibitors (FTIs). As a result of the studies described herein, highly potent FTIs with improved pharmacokinetic profiles have been identified. (C) 2001 Elsevier Science Ltd. All rights reserved.