(4-amino-benzoyl)-urea | 90223-18-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-amino-benzoyl)-urea
• 英文别名: (4-Amino-benzoyl)-harnstoff；(p-Aminobenzoyl)urea；4-amino-N-carbamoylbenzamide
• CAS: 90223-18-0
• 化学式: C₈H₉N₃O₂
• 分子量: 179.178
• InChiKey: UXHAGRRENABUAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-amino-benzoyl)-urea 、 氯乙酰氯 在 氯乙酸 作用下， 生成 [4-(2-chloro-acetylamino)-benzoyl]-urea
  参考文献：
  名称：

  Jacobs; Heidelberger, Journal of the American Chemical Society, 1917, vol. 39, p. 2437

  摘要：

  DOI：
• 作为产物：
  描述：

  (4-nitro-benzoyl)-urea 在 溶剂黄146 、 铂 作用下， 生成 (4-amino-benzoyl)-urea
  参考文献：
  名称：

  Risk-resistance adaptation model for caregivers and their children with sickle cell syndromes

  摘要：

  This investigation examined the risk-resistance adaptation model for children with sickle cell disease and their primary caregivers. Participants were 55 children, ranging in age from 5 to 16 years with a mean age of 9 years 2 months, diagnosed with sickle cell disease and their primary caregivers, recruited from a university medical center Measures included adjustment (i.e. primary caregiver and child adjustment), risk factors (i.e. disease and disability, functional independence, and psychosocial stressors), resistance factors (i.e, intrapersonal health locus of control, social-ecological), and stress processing (coping). Primary caregivers' adjustment was associated with developmental coping, R-change(2) = .08, and child adaptation was associated with an internal health locus of control, R-change(2) = .22. An indirect effect of primary caregivers' coping on child adjustment was found through influence on primary caregivers' adjustment, R-change(2) = .11. The findings support research among other chronically ill populations that suggests an association between coping and disease adjustment. The results were interpreted to support the use of theoretically driven models in predicting the adaptation of children with chronic illness and adjustment in their caregivers.

  DOI：

  10.1007/bf02895780

文献信息

• Aminobenzoic acid derivatives having anti-tumorigenic activity, methods of making and using the same
  申请人：——

  公开号：US20020022747A1

  公开（公告）日：2002-02-21

  Haloacetoamido, benzoic acid derivatives having anti-tumorigenic activity. Examples of the haloacetoamido, benzoic acid derivatives include 3-chloroacetoamido, benzoylurea, 3-bromoacetoamido, benzoylurea, 3-iodoacetoamido, benzoylurea, ethyl-3-chloroacetoamido, benzoate, ethyl-3-bromoacetoamido, benzoate and ethyl-3-iodoacetoamido, benzoate. Intermediates for synthesizing the derivatives, along with method of making and using the derivatives, are also provided.

  Haloacetoamido，苯甲酸衍生物具有抗肿瘤活性。Haloacetoamido，苯甲酸衍生物的例子包括3-氯乙酰胺，苯甲酰脲，3-溴乙酰胺，苯甲酰脲，3-碘乙酰胺，苯甲酰脲，乙基-3-氯乙酰胺，苯甲酸酯，乙基-3-溴乙酰胺，苯甲酸酯和乙基-3-碘乙酰胺，苯甲酸酯。还提供了合成衍生物的中间体，以及制备和使用衍生物的方法。
• Sayyah, S. M.; Mohamed, S. A.; El-Shafiey, Z. A., Egyptian Journal of Chemistry, 1995, vol. 38, # 3, p. 329 - 338
  作者：Sayyah, S. M.、Mohamed, S. A.、El-Shafiey, Z. A.、Farag, R. S.、Ewais, H. A.

  DOI：——

  日期：——
• US6294695B1
  申请人：——

  公开号：US6294695B1

  公开（公告）日：2001-09-25
• US6590123B2
  申请人：——

  公开号：US6590123B2

  公开（公告）日：2003-07-08
• Risk-resistance adaptation model for caregivers and their children with sickle cell syndromes
  作者：Ronald T. Brown、Richard Lambert、Danielle Devine、Kevin Baldwin、Robert Casey、Karla Doepke、Carolyn E. Ievers、Lewis Hsu、Iris Buchanan、James Eckman

  DOI：10.1007/bf02895780

  日期：2000.6

  This investigation examined the risk-resistance adaptation model for children with sickle cell disease and their primary caregivers. Participants were 55 children, ranging in age from 5 to 16 years with a mean age of 9 years 2 months, diagnosed with sickle cell disease and their primary caregivers, recruited from a university medical center Measures included adjustment (i.e. primary caregiver and child adjustment), risk factors (i.e. disease and disability, functional independence, and psychosocial stressors), resistance factors (i.e, intrapersonal health locus of control, social-ecological), and stress processing (coping). Primary caregivers' adjustment was associated with developmental coping, R-change(2) = .08, and child adaptation was associated with an internal health locus of control, R-change(2) = .22. An indirect effect of primary caregivers' coping on child adjustment was found through influence on primary caregivers' adjustment, R-change(2) = .11. The findings support research among other chronically ill populations that suggests an association between coping and disease adjustment. The results were interpreted to support the use of theoretically driven models in predicting the adaptation of children with chronic illness and adjustment in their caregivers.