2,2,4,4-tetramethylglutaric acid dimethyl ester | 34372-00-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,4,4-tetramethylglutaric acid dimethyl ester
• 英文别名: Dimethyl 2,2,4,4-tetramethylglutarate；Dimethyl-2,2,4,4-tetramethylglutarat；Dimethyl 2,2,4,4-tetramethylpentanedioate
• CAS: 34372-00-4
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: BSLJRBCGVKHLME-UHFFFAOYSA-N

物化性质

• 熔点：
  44-44.5 °C(Solv: hexane (110-54-3))
• 沸点：
  207.6±8.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  lithium diisopropyl amide 以92%的产率得到
  参考文献：
  名称：

  WEAGLEY R. J.; GIBSON H. W., SYNTHESIS,(1986) N 7, 552-554

  摘要：

  DOI：

文献信息

• Dialkylation of Diesters
  作者：Ronald J. Weagley、Harry W. Gibson

  DOI：10.1055/s-1986-31698

  日期：——

  Dimethyl and diethyl 2,2,4,4-tetramethylglutarates have been synthesized in greater than 92% yield by lithium diisopropylamide promoted methylation of the ester enolates of 2,4-dimethyl- and 2,2-dimethyl-glutaric acids. 1, 3-Dimethoxycarbonyl-1,3-dimethylcyclopentane was prepared in 84% yield by dimethylation of the corresponding diester. The latter dialkylation occurs in one step using two equivalents of base followed by two equivalents of methyl iodide, while the former requires a two step procedure, introducing one methyl group at a time.

  通过二异丙基酰胺锂促进 2,4 二甲基戊二酸和 2,2 二甲基戊二酸酯烯醇的甲基化，合成了 2,2,4,4-四甲基戊二酸二甲酯和二乙酯，收率超过 92%。通过对相应的二酯进行二甲基化反应，制备出了 1,3-二甲氧基羰基-1,3-二甲基环戊烷，收率为 84%。后者的二烷基化只需一步，使用两个当量的碱和两个当量的碘甲烷，而前者则需要两步，每次引入一个甲基。
• Surfactants from long-chain carbon-containing molecules
  申请人：SIRONIX RENEWABLES, INC.

  公开号：US10934266B2

  公开（公告）日：2021-03-02

  Compositions of furan based surfactants derived from unsaturated carbon-containing molecules, such as fatty acids, as well as methods for forming furan based surfactants from unsaturated carbon-containing molecules, such as fatty acids, are disclosed herein. These compositions and methods can utilize long-chain (e.g., C14-C26) unsaturated carbon-containing molecules, for instance unsaturated fatty acids such as oleic acid or methyl oleate from soybean oil, to derive oleo-furan surfactants. To facilitate this, certain such embodiments include reaction steps that cleave the reactant molecule (e.g., methyl oleate) at the double bond and subsequently oxidize products to form a carboxylic acid molecule and a dicarboxylic acid molecule. In such embodiments, these two acids can be subsequently acylated with furan and functionalized to form surfactants.

  本文公开了由不饱和含碳分子（如脂肪酸）衍生的呋喃基表面活性剂的组合物，以及由不饱和含碳分子（如脂肪酸）形成呋喃基表面活性剂的方法。这些组合物和方法可以利用长链（如 C14-C26）不饱和含碳分子，例如不饱和脂肪酸，如大豆油中的油酸或油酸甲酯，来衍生出油基呋喃表面活性剂。为了便于实现这一点，某些此类实施方案包括在双键处裂解反应物分子（如油酸甲酯）并随后氧化产物以形成羧酸分子和二羧酸分子的反应步骤。在这些实施方案中，这两种酸可随后与呋喃酰化并官能化，形成表面活性剂。
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  公开号：EP2614964B1

  公开（公告）日：2017-01-04
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  公开号：EP2809734B1

  公开（公告）日：2017-10-18
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