4-(1,3-dioxolan-2-yl)butan-1-ol | 83516-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 4-(1,3-dioxolan-2-yl)butan-1-ol
• CAS: 83516-55-6
• 化学式: C₇H₁₄O₃
• mdl: MFCD06209374
• 分子量: 146.186
• InChiKey: QUPUQCVMVRBUTO-UHFFFAOYSA-N

物化性质

• 沸点：
  226.6±15.0 °C(Predicted)
• 密度：
  1.052±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1,3-dioxolan-2-yl)butan-1-ol 在 pyridinium chlorochromate 作用下， 以60%的产率得到5,5-二羟基戊醛
  参考文献：
  名称：

  Reddy, C. P.; Rao, R. Balaji, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 4, p. 367 - 368

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-Dioxolan-2-buttersaeure-ethylester 在 lithium aluminium tetrahydride 作用下， 以80%的产率得到4-(1,3-dioxolan-2-yl)butan-1-ol
  参考文献：
  名称：

  Reddy, C. P.; Rao, R. Balaji, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 4, p. 367 - 368

  摘要：

  DOI：

文献信息

• Generation of Dithianyl and Dioxolanyl Radicals Using Photoredox Catalysis: Application in the Total Synthesis of the Danshenspiroketallactones via Radical Relay Chemistry
  作者：Yifan Deng、Minh D. Nguyen、Yike Zou、K. N. Houk、Amos B. Smith

  DOI：10.1021/acs.orglett.9b00271

  日期：2019.3.15

  Visible-light-induced generation of dithianyl and dioxolanyl radicals via selective hydrogen atom transfer (HAT) has been achieved. This radical relay tactic enables remote C(sp3)–H functionalization to permit rapid access to polyol and spiroketal segments, and in turn has been exploited as a key synthetic construct in the total synthesis of the danshenspiroketallactones. The conformational stability

  已经实现了通过选择性氢原子转移（HAT）的可见光诱导的二噻吩基和二氧戊环基自由基的产生。这种基本的中继策略使远程C（sp 3）-H功能化成为可能，从而允许快速访问多元醇和螺环酮链段，从而又被用作丹参螺酮内酯全合成中的关键合成结构。还通过实验和DFT计算确定了丹参螺酮内酯的构象稳定性。
• m-Terphenyl Ethers, a New Hydroxy Protecting Group Cleavable under Reductive Single Electron Transfer Reaction Conditions
  作者：Ugo Azzena、Luisa Pisano、Sarah Mocci

  DOI：10.1055/s-0030-1259997

  日期：2011.5

  m-Terphenyl ethers and, to a lesser extent, 2,6-dimeth­oxyphenyl ethers, were tested as protected hydroxy derivatives under a variety of reaction conditions. These ethers underwent regioselective cleavage of the aromatic C(1)-O bond under reductive SET reaction conditions using alkali metals in tetrahydrofuran at room temperature. This deprotective procedure was efficiently realized in the presence

  米三联苯醚和，在较小程度上，2,6-二甲氧基苯基醚，测试了作为在各种反应条件下被保护的羟基的衍生物。这些醚在室温下在四氢呋喃中使用碱金属在还原性SET反应条件下经历了芳香族C（1）-O键的区域选择性裂解。在几个其他官能团（包括缩醛，苯基烷基醚，未保护的醇以及碳-碳双键和三键）的存在下，可以有效地实现这种脱保护程序。此外，米-三联苯醚证明不同的反应条件，包括酸性水解和形成和/或不同的有机金属试剂的就业下是稳定的。 醇-电子转移-保护基-还原-钠
• NOVEL IMINOSUGARS AND THEIR APPLICATIONS
  申请人：The Chancellor, Masters and Scholars of the University of Oxford

  公开号：US20130331578A1

  公开（公告）日：2013-12-12

  Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogues of tocopherol or select analogues of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.

  本文描述了一类具有内置传递特性的伊米诺糖化合物，这是由于共价结合了生育酚基团或生育酚类似物或选择性胆固醇类似物或其拮抗剂“依贝普利”而实现的，并且可能具有广谱的抗病毒活性。这些化合物与以前的伊米诺糖化合物不同，即使是亲脂性的化合物，也更具亲水性，并且在体内分配到脂蛋白、细胞脂滴器官和生物膜的脂质相中，类似于脂肪和油。这些特征在体内具有许多独特的传递属性，有利于淋巴系统和肝脏细胞感染病毒的治疗，特别是对于人和动物的病毒感染治疗也是有利的。
• Iminosugars and their applications
  申请人：Unither Virology, LLC

  公开号：US08921568B2

  公开（公告）日：2014-12-30

  Iminosugar compounds are described that have inbuilt delivery features by virtue of covalent incorporation of a tocopherol moiety, or alternative moieties that are analogs of tocopherol or select analogs of cholesterol, or its antagonist “Ezitimibe”; and are likely to have broad spectrum antiviral activity. The compounds differ from previous iminosugar compounds, even lipophillic ones, being more hydrophobic and resembling fats and oils in their partition behavior in vivo into lipid phases of lipoproteins, cellular lipid droplet organelles and biological membranes. These features confer a number of unique delivery attributes in vivo, favorable to the therapy of virus infections involving cells of the lymphoid system and the liver, in particular, but these features are also favorable in general for the treatment of virus infections of man and animals.

  本文描述了一种具有内置传递特性的伊米诺糖类化合物，这是由于其共价结合了生育酚基团，或是生育酚或胆固醇选择类似物或其拮抗剂“依折麦布”的类似物; 并且很可能具有广谱的抗病毒活性。这些化合物与以前的伊米诺糖化合物不同，即使是亲脂性的化合物，它们更具亲水性，并且在体内的分配行为类似于脂肪和油。这些特征在体内赋予了许多独特的传递属性，有利于治疗涉及淋巴系统和肝脏细胞的病毒感染，特别是在一般情况下，这些特征也有利于治疗人和动物的病毒感染。
• Vaccine against Klebsiella pneumoniae
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：US11479574B2

  公开（公告）日：2022-10-25

  The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Klebsiella pneumoniae bacteria.

  本发明涉及一种与肺炎克雷伯菌血清型O1、O2、O2ac和O8 O-多糖以及耐碳青霉烯类肺炎克雷伯菌ST258 O-多糖有关的通式（I）合成糖及其共轭物。所述合成糖、所述共轭物和含有所述合成糖或所述共轭物的药物组合物可用于预防和/或治疗与肺炎克雷伯氏菌相关的疾病。此外，通式（I）的合成糖苷可作为免疫学试验中的标记物，用于检测针对肺炎克雷伯氏菌的抗体。