2-氰基苯肼 | 63589-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氰基苯肼
• 中文别名: 2-肼基苯甲腈
• 英文名称: 2-hydrazino-benzonitrile
• 英文别名: 2-Cyanophenylhydrazine；Benzonitrile, 2-hydrazino-；2-hydrazinylbenzonitrile
• CAS: 63589-18-4
• 化学式: C₇H₇N₃
• 分子量: 133.153
• InChiKey: HINFZKWHKTZDQX-UHFFFAOYSA-N

物化性质

• 沸点：
  315.0±25.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.8
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2-氰基苯肼 在 copper(l) cyanide 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 2-(5-(2-methoxyphenyl)-6-oxo-3-(pyridin-2-yl)-1,6-dihydropyridazin-1-yl)benzonitrile
  参考文献：
  名称：

  Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors

  摘要：

  We document the development of PET probes for central AMPA receptors and their application to in vivo animal imaging. An initial screening of perampanel derivatives was performed to identify probe candidates. Despite the high autoradiographic contrast yielded by several radioligands, rat PET scans did not support their in vivo suitability. Further focused derivatization and a second screening by ex vivo LC-MS measurements led to the selection of 2-[1-(3-methylaminophenyl)-2-oxo-5-(pyrimidin-2-yl)1,2-dihydropyridin-3-yl]benzonitrile, 21a, and its analogues as candidates. [C-11]21a was shown by autoradiography to specifically bind to the neocortex and hippocampus, consistent with AMPA receptor localization. PET imaging with [C-11]21a demonstrated moderate uptake of radioactivity in rat and monkey brains, with the retention of radiosignals being consistent with that from the autoradiogram data, and the uptake was blocked by pretreatment with unlabeled 21a in a dose-dependent manner. The current approach has facilitated the discovery of a PET probe potentially suitable for translational research and development focused on AMPA receptors.

  DOI：

  10.1021/acs.jmedchem.5b00712
• 作为产物：
  描述：

  盐酸 、 N-benzo[d][1,2,3]triazin-4-yl-hydroxylamine; hydrochloride 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-氰基苯肼
  参考文献：
  名称：

  Gabriel, Chemische Berichte, 1903, vol. 36, p. 808

  摘要：

  DOI：

文献信息

• 2-Methyl-5-Imino-Benzo[D][1,3]Oxazin[5-B]Pyrazole Compound, Preparation and Use Thereof
  申请人：Su Guoqiang

  公开号：US20110118247A1

  公开（公告）日：2011-05-19

  The present invention disclosed compound 2-methyl-5-imino-benzo[d][1,3]oxazin[5-b]pyrazole and preparation method and uses thereof. The compound 2-methyl-5-imino-benzo[d][1,3]oxazin[5-b]pyrazole of the present invention has the following structure of formula (II), wherein the compound or pharmaceutically acceptable salts thereof can be used for preparing the drugs for treatment or prevention of cardiovascular diseases.

  本发明公开了化合物2-甲基-5-亚胺基-苯并[d][1,3]氧氮杂[5-b]吡唑及其制备方法和用途。本发明的化合物2-甲基-5-亚胺基-苯并[d][1,3]氧氮杂[5-b]吡唑具有如下式(II)的结构，其中该化合物或其药用可接受盐可用于制备治疗或预防心血管疾病的药物。
• [EN] INHIBITION OF ENZYMES<br/>[FR] INHIBITION D'ENZYMES
  申请人：CHIESI FARMA SPA

  公开号：WO2014009425A1

  公开（公告）日：2014-01-16

  Compounds of formula (I) are inhibitors of neutrophil elastase wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I).

  式（I）的化合物是中性粒细胞弹性蛋白酶的抑制剂，其中R1、R2、R3、R5、R6、A1、A2、A3、A4的含义如式（I）中所定义。
• [EN] HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS AMINO-PYRIDINE SUBSTITUÉS HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：EPIZYME INC

  公开号：WO2016044666A1

  公开（公告）日：2016-03-24

  The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

  本公开涉及杂环取代的氨基吡啶化合物。本公开还涉及含有这些化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要的受试者来治疗癌症的方法。本公开还涉及将这些化合物用于研究或其他非治疗目的的用途。
• 1-alkyl-3-aminoindazoles
  申请人：Delgado Pete

  公开号：US20060052613A1

  公开（公告）日：2006-03-09

  Methods of making 1-alkylindazoles are described. The methods involve reacting a 2-alkylaminobenzonitrile with a nitrosating agent followed by reduction-cyclization of the resulting nitrosamine to form a 1-alkyl-3-aminoindazole. The 1-alkyl-3-aminoindazole can be deaminated to form a 1-alkylindazole which ultimately can be used to form desired indazoles which are preferably pharmaceutically active products. The process of the present invention further permits the formation of enantiomerically enriched or pure indazoles such as aminoalkyl indazoles.

  本文描述了制备1-烷基吲唑的方法。该方法涉及将2-烷基氨基苯甲腈与亚硝基化剂反应，随后还原-环化生成1-烷基-3-氨基吲唑。1-烷基-3-氨基吲唑可以脱氨基形成1-烷基吲唑，最终可以用于形成所需的吲唑，这些吲唑最好是具有药理活性的产品。本发明的过程还允许形成对映富集或纯的吲唑，如氨基烷基吲唑。
• TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS
  申请人：Fales Kevin Robert

  公开号：US20100022550A1

  公开（公告）日：2010-01-28

  The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of formula (I).

  本发明提供了以下公式的化合物：公式（I）或其药学上可接受的盐；包含有效量公式（I）化合物与适当载体、稀释剂或赋形剂的制剂；以及治疗生理障碍，特别是虚弱，骨质疏松，骨质疏松症和男女性功能障碍的方法，包括向需要的患者给予公式（I）化合物的有效量。