(R)-3-methyl-valeric acid amide | 53254-70-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-methyl-valeric acid amide
• 英文别名: (R)-3-Methyl-valeriansaeure-amid；(3R)-3-methylpentanamide
• CAS: 53254-70-9；61892-69-1；65137-49-7
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: SIMLCFANWCDGAF-RXMQYKEDSA-N

物化性质

• 沸点：
  245.2±8.0 °C(Predicted)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  methyl 3-methylpentanoate 在 氢氧化钾 、 草酰氯 、 苯 作用下， 生成 (R)-3-methyl-valeric acid amide
  参考文献：
  名称：

  Staellberg; Stenhagen, Arkiv foer Kemi, 1950, vol. 2, p. 95,102

  摘要：

  DOI：

文献信息

• [EN] CRF1 RECEPTOR COMPOUNDS<br/>[FR] COMPOSÉS DE RÉCEPTEUR CRF1
  申请人：ANCHOR THERAPEUTICS INC

  公开号：WO2010053546A2

  公开（公告）日：2010-05-14

  The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) receptor 1, also known as the CRF1, CRHR1, CRFR1, CRHR, CRF-R. The CRF1 receptor compounds are derived from the intracellular loops and domains of CRF1 receptor. The invention also relates to the use of these CRF1 receptor compounds and pharmaceutical compositions comprising the CRF1 receptor compounds in the treatment of diseases and conditions associated with CRF1 receptor modulation, such as inflammatory bowel disease (peripherally acting), irritable bowel syndrome (IBS), stress response (colonic motor activity), anxiety, sleep disorder, addictive behavior, acute and chronic neurodegeneration, preterm labor and pain.
• Staellberg; Stenhagen, Arkiv foer Kemi, 1950, vol. 2, p. 95,102
  作者：Staellberg、Stenhagen

  DOI：——

  日期：——