N-Phenyl-carbimidsaeure-phenylester | 1083-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Phenyl-carbimidsaeure-phenylester
• 英文别名: N-Phenyl-O-phenyl-isoharnstoff；N.O-Diphenyl-isoharnstoff；O.N-Diphenyl-isoharnstoff；phenyl N'-phenylcarbamimidate
• CAS: 1083-50-7
• 化学式: C₁₃H₁₂N₂O
• 分子量: 212.251
• InChiKey: XKXBDQZRRCEMFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Phenyl-carbimidsaeure-phenylester 、 乙酰氯 在 三乙胺 作用下， 生成 N.O-Diphenyl-N'-acetyl-isoharnstoff
  参考文献：
  名称：

  Grigat,E.; Puetter,R., Chemische Berichte, 1964, vol. 97, p. 3027 - 3035

  摘要：

  DOI：
• 作为产物：
  描述：

  氰酸苯酯 、 苯胺 在 苯甲酸 作用下， 以 四氢呋喃 为溶剂， 生成 N-Phenyl-carbimidsaeure-phenylester
  参考文献：
  名称：

  Martin,D., Chemische Berichte, 1965, vol. 98, p. 3286 - 3296

  摘要：

  DOI：

文献信息

• [EN] N-SUBSTITUTED-3-TRICYCLYL PIPERIDINE DERIVATIVES AS ANTICANCER AND NEUROPROTECTIVE AGENTS<br/>[FR] DÉRIVÉS DE 3-TRICYCLYL-PIPÉRIDINES N-SUBSTITUÉES UTILISÉS EN TANT QU'AGENTS ANTICANCÉREUX ET NEUROPROTECTEURS
  申请人：ICAHN SCHOOL MED MOUNT SINAI

  公开号：WO2021150697A1

  公开（公告）日：2021-07-29

  A genus of N-substituted-3-tricyclyl piperidine derivatives is disclosed. The compounds are of the following genus: The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

  揭示了一种N-取代-3-三环戊二酰基哌啶衍生物的属。这些化合物属于以下属：这些化合物通过调节PP2A诱导FOXO1转录因子转位到细胞核，从而表现出抗增殖效应。它们在治疗各种疾病方面很有用，包括作为单药治疗癌症，或与其他药物联合使用以恢复对化疗的敏感性，尤其是在出现耐药性时。
• Martin,D. et al., Angewandte Chemie, 1965, vol. 77, p. 96 - 97
  作者：Martin,D. et al.

  DOI：——

  日期：——
• CYANOGUANIDINE-BASED AZOLE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1658071A2

  公开（公告）日：2006-05-24
• [EN] CYANOGUANIDINE-BASED AZOLE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS<br/>[FR] COMPOSES AZOLE A BASE DE CYANOGUANIDINE-UTILISES COMME INHIBITEURS DE MALONYL-COA DECARBOXYLASE
  申请人：CHUGAI PHARMACEUTICAL CO LTD

  公开号：WO2005037258A2

  公开（公告）日：2005-04-28

  The present invention provides methods for the use of compounds as depicted by structure (I), pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
• [EN] WATER-BASED PAINT COMPOSITIONS AND MULTILAYER COATING FILM FORMING METHOD<br/>[FR] COMPOSITIONS DE PEINTURE À L'EAU ET PROCÉDÉ DE FORMAGE DE FILM DE REVÊTEMENT MULTICOUCHE
  申请人：KANSAI PAINT CO LTD

  公开号：WO2008123387A2

  公开（公告）日：2008-10-16

  [EN] This invention provides water-based paint compositions containing waterdispersible acrylic polymer particles, hydroxyl- containing resin and curing agent, the water-dispersible acrylic polymer particles having a weight-average molecular weight of at least 1,100,000 and an absorbance value not higher than 0.2 at a wavelength of 330 nm, as measured with spectrophotometer in the state of liquid dispersion at a mass concentration of 1.35% in 1,4- dioxane solvent; and the compositions excelling in finished appearance such as coated surface smoothness and coating film performance such as chipping resistance and water resistance.
  [FR] L'invention concerne des compositions de peinture à l'eau contenant des particules polymères acryliques dispersibles dans l'eau, une résine contenant de l'hydroxyle et un agent de durcissement, les particules polymères acryliques dispersibles dans l'eau ayant un poids moléculaire moyen en poids d'au moins 1 100 000 et une valeur d'absorbance n'excédant pas 0,2 à une longueur d'onde de 330nm, mesurée au moyen d'un spectrophotomètre à l'état de dispersion liquide à une teneur massique de 1,35% dans un solvant de 1,4-dioxane; les compositions présentant un aspect fini excellent, par exemple le lissé de surface revêtue et l'efficacité du film de revêtement notamment en matière de résistance à l'abrasion et de résistance à l'eau.