5-[(1R,2R)-2-hydroxy-1,3-bis(phenylmethoxy)propyl]-4H-1,2-oxazol-5-ol | 476372-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[(1R,2R)-2-hydroxy-1,3-bis(phenylmethoxy)propyl]-4H-1,2-oxazol-5-ol
• CAS: 476372-01-7
• 化学式: C₂₀H₂₃NO₅
• 分子量: 357.406
• InChiKey: MEZYSKJBLJZDHQ-LEAGNCFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  80.5
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-[(1R,2R)-2-hydroxy-1,3-bis(phenylmethoxy)propyl]-4H-1,2-oxazol-5-ol 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 以94%的产率得到(1R,2R)-1-(1,2-oxazol-5-yl)-1,3-bis(phenylmethoxy)propan-2-ol
  参考文献：
  名称：

  Glycal-mediated synthesis of enantiomerically pure 5-substituted isoxazoles containing a differentially O-benzylated glycerol moiety

  摘要：

  A short. glycal-mediated synthesis of new chiral 5-substituted isoxazoles bearing a differentially O-protected glycerol moiety in the side chain has been accomplished. An X-ray crystallographic structural analysis confirmed the structural assignment of the new products. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00872-9
• 作为产物：
  描述：

  D-葡萄烯糖 在 碘苯二乙酸 、 羟胺 、 sodium hydride 、 对甲苯磺酸 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 4.75h， 生成 5-[(1R,2R)-2-hydroxy-1,3-bis(phenylmethoxy)propyl]-4H-1,2-oxazol-5-ol
  参考文献：
  名称：

  Glycal-mediated synthesis of enantiomerically pure 5-substituted isoxazoles containing a differentially O-benzylated glycerol moiety

  摘要：

  A short. glycal-mediated synthesis of new chiral 5-substituted isoxazoles bearing a differentially O-protected glycerol moiety in the side chain has been accomplished. An X-ray crystallographic structural analysis confirmed the structural assignment of the new products. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00872-9

文献信息

• Glycal-mediated synthesis of enantiomerically pure 5-substituted isoxazoles containing a differentially O-benzylated glycerol moiety
  作者：Hans-Georg Weinig、Pietro Passacantilli、Marcello Colapietro、Giovanni Piancatelli

  DOI：10.1016/s0040-4039(02)00872-9

  日期：2002.5

  A short. glycal-mediated synthesis of new chiral 5-substituted isoxazoles bearing a differentially O-protected glycerol moiety in the side chain has been accomplished. An X-ray crystallographic structural analysis confirmed the structural assignment of the new products. (C) 2002 Elsevier Science Ltd. All rights reserved.