acrylic phosphoramidite | 1226983-36-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acrylic phosphoramidite
• 英文别名: N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]-2-methylprop-2-enamide
• CAS: 1226983-36-3
• 化学式: C₁₉H₃₆N₃O₃P
• 分子量: 385.487
• InChiKey: DZRKHCTWELOFAU-UHFFFAOYSA-N

物化性质

• 沸点：
  484.9±45.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-氨基-1-己醇 在 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 7.25h， 生成 acrylic phosphoramidite
  参考文献：
  名称：

  Macroscopic Volume Change of Dynamic Hydrogels Induced by Reversible DNA Hybridization

  摘要：

  Molecular recognition is fundamental to the specific interactions between molecules, of which the best known examples are antibody antigen binding and cDNA hybridization. Reversible manipulation of the molecular recognition events is still a very challenging topic, and such studies are often performed at the molecular level. An important consideration is the collection of changes at the molecular level to provide macroscopic observables. This research makes use of photoresponsive molecular recognition for the fabrication of novel photoregulated dynamic materials. Specifically, a dynamic hydrogel was prepared by grafting azobenzene-tethered ssDNA and its cDNA to the hydrogel network. The macroscopic volume Of the hydrogel can be manipulated through the photoreversible DNA hybridization controlled by alternate irradiation of UV and visible light. The effects of synthetic parameters including the concentration of DNA, polymer monomer, and permanent cross-linker are also discussed.

  DOI：

  10.1021/ja305109n

文献信息

• Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy
  作者：Cuichen Wu、Da Han、Tao Chen、Lu Peng、Guizhi Zhu、Mingxu You、Liping Qiu、Kwame Sefah、Xiaobing Zhang、Weihong Tan

  DOI：10.1021/ja4094617

  日期：2013.12.11

  which may not be suitable for certain types of cancers, especially for treatment in vivo. To meet this need, we have constructed a multifunctional aptamer-based DNA nanoassembly (AptNA) for targeted cancer therapy. In particular, we first designed various Y-shaped functional DNA domains through predesigned base pair hybridization, including targeting aptamers, intercalated anticancer drugs, and therapeutic

  通过 DNA/RNA 纳米技术将一维 DNA 构建块自组装成二维和三维纳米结构的能力已导致在生物成像、基础生物机制研究、疾病诊断和药物输送方面的广泛应用。然而，大多数核酸纳米结构的细胞摄取依赖于被动传递或增强的渗透性和滞留效应，这可能不适用于某些类型的癌症，尤其是体内治疗。为了满足这一需求，我们构建了一种多功能的基于适配体的 DNA 纳米组装 (AptNA)，用于靶向癌症治疗。特别是，我们首先通过预先设计的碱基对杂交设计了各种 Y 形功能性 DNA 结构域，包括靶向适体、嵌入的抗癌药物和治疗性反义寡核苷酸。然后，这些功能性 DNA 域通过功能域和连接器臂中的互补序列连接到 X 形 DNA 核心连接器，称为构建单元。最后，数百（~100-200）个带有 5' 丙烯酸酯基团修饰的基本构建单元被进一步光交联成多功能和可编程的基于适配体的纳米组装结构，能够利用简单的模块化设计和组装，高可编程性、优
• An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection
  作者：Zhi Zhu、Cuichen Wu、Haipeng Liu、Yuan Zou、Xiaoling Zhang、Huaizhi Kang、Chaoyong James Yang、Weihong Tan

  DOI：10.1002/anie.200905570

  日期：2010.2.1

  Cocaine cracked: The gel–sol transition of an enzyme‐caged hydrogel has been efficiently controlled by target binding events, which trigger release of the enzyme to take part in its catalytic role for signal amplification (see picture). As low as 20 ng of cocaine can be visually detected within 10 min without any aid of sophisticated instrumentation.

  可卡因裂解：酶结合水凝胶的凝胶-溶胶转变已受到靶标结合事件的有效控制，这些事件会触发酶的释放，从而参与其对信号放大的催化作用（见图）。无需任何精密仪器，即可在10分钟内目视检测到20 ng可卡因。
• Colorimetric logic gates based on aptamer-crosslinked hydrogels
  作者：Bin-Cheng Yin、Bang-Ce Ye、Hui Wang、Zhi Zhu、Weihong Tan

  DOI：10.1039/c1cc15639j

  日期：——

  We have developed a novel molecular logic gate system based on the incorporation of aptamer-crosslinked hydrogels. Modified gold nanoparticles are used as the output signal, which is visible to the naked eye. This system is designed for AND and OR operations using two chemicals as stimulus inputs.

  我们开发了一种新型分子逻辑门系统，其基础是加入了aptamer-交联水凝胶。改性金纳米粒子被用作输出信号，肉眼可见。该系统设计用于以两种化学物质作为刺激输入进行 AND 和 OR 运算。
• PURIFICATION OF SYNTHETIC OLIGONUCLEOTIDES
  申请人：Fang Shiyue

  公开号：US20130211065A1

  公开（公告）日：2013-08-15

  This invention provides a method for purifying synthetic oligonucleotides comprising capping, polymerizing and separating any failure sequences produced during oligonucleotide synthesis. The invention also provides a method for purifying synthetic oligonucleotides comprising reacting a full length oligonucleotide with a compound to attach a polymerizable functional group to an end of the full length oligonucleotide, polymerizing the full length oligonucleotides and removing the failure sequences, and recovering the full length oligonucleotides. The invention also provides novel capping agents having a polymerizable functional group, and kits comprising at least one composition of the present invention.

  本发明提供了一种纯化合成寡核苷酸的方法，包括在寡核苷酸合成过程中进行帽子化、聚合和分离任何产生的失败序列。本发明还提供了一种纯化合成寡核苷酸的方法，包括将完整长度的寡核苷酸与化合物反应，将可聚合的功能基团附加到完整长度的寡核苷酸末端，聚合完整长度的寡核苷酸并去除失败序列，最后回收完整长度的寡核苷酸。本发明还提供了具有可聚合功能基团的新型帽子试剂，以及包含本发明至少一种组分的试剂盒。
• Joined body joined by chemical bonding at material interface, and joining method for joined body
  申请人：Osaka University

  公开号：US10174172B2

  公开（公告）日：2019-01-08

  The present invention provides a joined body with no risk of detachment from the joining surface without using an adhesive, and a method for producing the joined body. The present invention also provides a reversible joined body that enables control of joining and dissociation, and a method for producing the reversible joined body. In the joined body, a chemical bond is formed between two or more same or different solid-state materials at their contact interfaces by a chemical reaction.

  本发明提供了一种在不使用粘合剂的情况下不会从接合面脱落的接合体，以及生产该接合体的方法。本发明还提供了一种可控制接合和解离的可逆接合体，以及一种生产可逆接合体的方法。在接合体中，两种或两种以上相同或不同的固态材料通过化学反应在其接触界面上形成化学键。