Methyl 3-(2-hydroxyethylamino)-2-methylpropanoate | 24356-15-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 3-(2-hydroxyethylamino)-2-methylpropanoate
• CAS: 24356-15-8
• 化学式: C₇H₁₅NO₃
• mdl: MFCD12193172
• 分子量: 161.201
• InChiKey: GHIYFNJPVPGKQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 N-(2-Hydroxyethyl)-2-methyl-β-alanin 生成 Methyl 3-(2-hydroxyethylamino)-2-methylpropanoate
  参考文献：
  名称：

  N-（2-氯乙基）-DL-天冬氨酸和一些相关氨基酸。

  摘要：

  DOI：

  10.1021/jm00324a054

文献信息

• Lipase-Catalyzed Aza-Michael Reaction on Acrylate Derivatives
  作者：Peter Steunenberg、Maarten Sijm、Han Zuilhof、Johan P. M. Sanders、Elinor L. Scott、Maurice C. R. Franssen

  DOI：10.1021/jo400268u

  日期：2013.4.19

  A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas viscosum lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations.
• N-(2-Chloroethyl)-DL-aspartic Acid and Some Related Amino Acids
  作者：Jaime Lores Arnaiz、Juana Falszpan

  DOI：10.1021/jm00324a054

  日期：1966.11