9,10-(anthrylenedimethylene)bis(1-piperidine) | 101058-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9,10-(anthrylenedimethylene)bis(1-piperidine)
• 英文别名: 9,10-bis-piperidinomethyl-anthracene；9,10-Bis-piperidinomethyl-anthracen；1-{[10-(Piperidinomethyl)-9-anthryl]methyl}piperidine；1-[[10-(piperidin-1-ylmethyl)anthracen-9-yl]methyl]piperidine
• CAS: 101058-32-6
• 化学式: C₂₆H₃₂N₂
• mdl: MFCD00356395
• 分子量: 372.553
• InChiKey: PFDLZDOYLGOGKS-UHFFFAOYSA-N

物化性质

• 熔点：
  204 °C(Solv: ethanol (64-17-5); acetone (67-64-1))
• 沸点：
  528.1±30.0 °C(Predicted)
• 密度：
  1.127±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  蒽 在 盐酸 、 磷酸 、 溶剂黄146 作用下， 生成 9,10-(anthrylenedimethylene)bis(1-piperidine)
  参考文献：
  名称：

  Gudrimieze; Wanag, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 3123

  摘要：

  DOI：

文献信息

• Spectroscopic Identification of Binding Modes of Anthracene Probes and DNA Sequence Recognition†
  作者：Willy B. Tan、Akhilesh Bhambhani、Michael R. Duff、Alison Rodger、Challa V. Kumar

  DOI：10.1562/2005-05-24-ra-539

  日期：——

  The binding properties of two anthracene derivatives with calf thymus DNA (CT DNA), poly(dA-dT), and poly(dG)-poly(dC) are reported. One contained bulky, cyclic cationic substituents at the 9 and 10 positions, and the other carried acylic, branched, cationic substituents. Binding of the probes to the DNA was examined by calorimetry, spectroscopy and helix melting studies. The cyclic derivative indicated exothermic binding, strong hypochromism, bathochromism, positive induced circular dichroism (CD, 300-400 nm), significant unwinding of the helix, large increases in the helix melting temperature, strong but negative linear dichroism (LD, 300-400 nm) and considerable stabilization of the helix. In contrast, the acyclic analog indicated thermoneutral binding, smaller hypochromism, no bathochromism, very weak induced CD, and no change in the helix melting temperature with any of the DNA polymers. A sharp distinction between the binding properties of the two probes is indicated, and both have intrinsic binding constants of similar to 10(6) M-1 for the three polymers. However, when the ionic strength of the medium was lowered (10 mM NaCl), the absorption as well as CD spectral changes associated with the binding of the acyclic derivative corresponded with those of the cyclic derivative. The acyclic derivative showed large preference (10-fold) for poly(dG).oly(dC) over poly(dA-dT), whereas the cyclic analog showed no preference. The characteristic spectroscopic signatures of the two distinct binding modes of these probes will be helpful in deciphering the interaction of other anthracene derivatives with DNA.
• Gudrimieze; Wanag, Zhurnal Obshchei Khimii, 1956, vol. 26, p. 3123
  作者：Gudrimieze、Wanag

  DOI：——

  日期：——