anti-CH3O2CC(Sn(C4H9)3)C(CO2CH3)C4H3O | 1011497-79-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: anti-CH3O2CC(Sn(C4H9)3)C(CO2CH3)C4H3O
• CAS: 1011497-79-2
• 化学式: C₂₂H₃₆O₅Sn
• 分子量: 499.235
• InChiKey: IXWUZDOFAXQTGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.77
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(三丁基锡烷基)呋喃 、 丁炔二酸二甲酯 在 tris(dibenzylideneacetone)dipalladium (0) 作用下， 以 二氯甲烷 为溶剂， 生成 anti-CH3O2CC(Sn(C4H9)3)C(CO2CH3)C4H3O 、 anti-CH3O2CC(Sn(C4H9)3)C(CO2CH3)C4H3O
  参考文献：
  名称：

  Alkynes as Stille Reaction Pseudohalides:  Gold- and Palladium-Cocatalyzed Synthesis of Tri- and Tetra-Substituted Olefins

  摘要：

  A Stille-type reaction that employs alkynes as pseudohalides provides access to the catalytic chemistry of palladium-carbon sigma-bonds starting from pi-systems. The synthesis of a variety of tri- and tetra-substituted olefins by addition of sp(2)- and sp-hybridized stannanes across mono- and diester alkynes was accomplished with complete regioselectivity and high stereoselectivity. The reaction is proposed to proceed via a bimetallic mechanism where the Lewis acidic Au(I) activates the alkyne toward oxidative addition across Pd(0).

  DOI：

  10.1021/ja710648b

文献信息

• Alkynes as Stille Reaction Pseudohalides:  Gold- and Palladium-Cocatalyzed Synthesis of Tri- and Tetra-Substituted Olefins
  作者：Yili Shi、Sonja M. Peterson、Walter W. Haberaecker、Suzanne A. Blum

  DOI：10.1021/ja710648b

  日期：2008.2.1

  A Stille-type reaction that employs alkynes as pseudohalides provides access to the catalytic chemistry of palladium-carbon sigma-bonds starting from pi-systems. The synthesis of a variety of tri- and tetra-substituted olefins by addition of sp(2)- and sp-hybridized stannanes across mono- and diester alkynes was accomplished with complete regioselectivity and high stereoselectivity. The reaction is proposed to proceed via a bimetallic mechanism where the Lewis acidic Au(I) activates the alkyne toward oxidative addition across Pd(0).