(E)-2-(3-(4-nitrophenyl)allyl)isoindoline-1,3-dione | 83665-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (E)-2-(3-(4-nitrophenyl)allyl)isoindoline-1,3-dione
• 英文别名: (E)-N-[3-(p-nitrophenyl)-2-propenyl]phthalimide；(Z)-N-[3-(p-nitrophenyl)-2-propenyl]phthalimide；2-[(E)-3-(4-nitrophenyl)prop-2-enyl]isoindole-1,3-dione
• CAS: 83665-62-7
• 化学式: C₁₇H₁₂N₂O₄
• 分子量: 308.293
• InChiKey: UOAQENQLMTYSKZ-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-2-(3-(4-nitrophenyl)allyl)isoindoline-1,3-dione 在 sodium hydroxide 、 一水合肼 作用下， 生成 (E)-3-(4-nitrophenyl)prop-2-en-1-amine
  参考文献：
  名称：

  Palladium-catalyzed synthesis of cinnamylamines

  摘要：

  DOI：

  10.1021/jo00148a033
• 作为产物：
  描述：

  4-硝基碘苯 、 N-烯丙基邻苯二甲酰亚胺 在 palladium diacetate 、 三乙胺 作用下， 反应 18.0h， 以70%的产率得到(E)-2-(3-(4-nitrophenyl)allyl)isoindoline-1,3-dione
  参考文献：
  名称：

  Palladium-catalyzed synthesis of cinnamylamines

  摘要：

  DOI：

  10.1021/jo00148a033

文献信息

• [EN] METHODS OF REDUCING VIRULENCE IN BACTERIA<br/>[FR] PROCÉDÉS DE RÉDUCTION DE LA VIRULENCE DE BACTÉRIES
  申请人：UWM RES FOUNDATION INC

  公开号：WO2011103189A1

  公开（公告）日：2011-08-25

  A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.

  一种减少细菌毒力的方法，包括至少一个GacS/GacA型系统、一个HrpX/HrpY型系统、一个T3SS型系统和一个Rsm型系统，该方法包括将细菌与本文描述的化合物的有效量接触。
• METHODS OF REDUCING VIRULENCE IN BACTERIA
  申请人：Yang Ching-Hong

  公开号：US20120322769A1

  公开（公告）日：2012-12-20

  A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.

  一种减少细菌毒力的方法，包括至少一种GacS/GacA型系统、HrpX/HrpY型系统、T3SS型系统和Rsm型系统中的一种，该方法包括将细菌与本文所述化合物的有效量接触。
• Substrate-Directable Heck Reactions with Arenediazonium Salts. The Regio- and Stereoselective Arylation of Allylamine Derivatives and Applications in the Synthesis of Naftifine and Abamines
  作者：Patrícia Prediger、Laís Ferreira Barbosa、Yves Génisson、Carlos Roque Duarte Correia

  DOI：10.1021/jo201105z

  日期：2011.10.7

  The palladium-catalyzed, substrate-directable Heck-Matsuda reaction of allylamine derivatives with arenediazonium salts is reported. The reaction proceeds under mild conditions, with excellent regio- and stereochemical control as a function of coordinating groups present in the allylamine substrate. The distance between the olefin moiety and the carbonylic system seems to play a key role regarding the regiocontrol. The method presents itself as robust, as simple to carry out, and with wide synthetic scope concerning the allylic substrates and the type of arenediazonium employed. The synthetic potential of the method is illustrated by the short total syntheses of the bioactive compounds naftifine, abamine, and abamine SG.
• Convenient Route to Primary (<i>Z</i>)-Allyl Amines and Homologs
  作者：Alejandra Gerpe、Mariela Bollini、Mercedes González、Hugo Cerecetto

  DOI：10.1080/00397910802369596

  日期：2008.12.16

  A convenient two-step procedure for the synthesis of primary (Z)-allyl amines, (Z)-homoallyl amines [(Z)-but-3-enylamines], and (Z)-pent-4-enylamines using the Wittig reaction was achieved. The use of nonstabilized ylides from triphenylphosphonium salt, potassium salt, and apolar solvent produced (Z/E)geometric isomer ratios generally greater than 1.6. The amine moiety was masked using a phtalimide group that was removed successfully in the last step of the process in two different conditions, NH2NH2/EtOH/rt or CH3NH2/EtOH/rt. However, in some cases, reduction of the C=C double bond in the deprotection with hydrazine was concomitantly observed.
• MALEK, N. J.;MOORMANN, A. E., J. ORG. CHEM., 1982, 47, N 27, 5395-5397
  作者：MALEK, N. J.、MOORMANN, A. E.

  DOI：——

  日期：——