2-溴-3-甲氧基丁酸 | 67819-23-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-溴-3-甲氧基丁酸
• 英文名称: S-2-Bromo-3-methoxybutanoic acid
• 英文别名: 2-Bromo-3-methoxybutanoic acid；2-bromo-3-methoxybutyric acid
• CAS: 67819-23-2
• 化学式: C₅H₉BrO₃
• 分子量: 197.029
• InChiKey: YVNDJNXUZODJQG-UHFFFAOYSA-N

物化性质

• 熔点：
  62-63 °C
• 沸点：
  105-106 °C(Press: 2 Torr)
• 密度：
  1.563±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  2-溴-3-甲氧基丁酸 生成 2-Amino-3-methoxybutanoic acid
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  巴豆酸 生成 2-溴-3-甲氧基丁酸
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Orally effective anti-hypertensive agents
  申请人：University of Miami

  公开号：US04745124A1

  公开（公告）日：1988-05-17

  Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, R.sub.1 -A.sub.1 -S-Z, wherein Z denotes -B-A.sub.2, R.sub.1 is H or an acyl group, A.sub.1 is a carboxylic acid containing at least one amino or imino -N-, A.sub.2 is a carboxylic acid containing at least one amino or imino -N- or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A.sub.2. Preferably A.sub.2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.

  披露了新型硫醇酯化合物，它们是口服有效的血管紧张素转化酶抑制剂，用于治疗哺乳动物的 hypertension。它们具有以下公式，R.sub.1 -A.sub.1 -S-Z，其中 Z 表示 -B-A.sub.2，R.sub.1 是 H 或一个酰基团，A.sub.1 是至少含有一个氨基或亚氨基 -N- 的羧酸，A.sub.2 是至少含有一个氨基或亚氨基 -N- 的羧酸或其低级烷基酯或酰胺，B 是一个 2-4 碳骨架链，通过巯基连接到 S，并包括一个碳酰基或磺酰基团，分别通过羧酰胺或磺酰胺连接到 A.sub.2。优选的是 A.sub.2 包含一个 4-6 成员的 C-N 环或一个由一个 N、一个 S 和 3 个 C 原子组成的 5 成员环。
• Anti-hypertensive agents
  申请人：University of Miami

  公开号：US04690936A1

  公开（公告）日：1987-09-01

  Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.

  揭示了具有一般公式R--A--S--Z的新型血管紧张素转化酶抑制剂，作为血管紧张素转化酶的强效抑制剂，并且是有用的降压药物。
• Pyrrolidine and piperidine-2-carboxylic acid derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04116962A1

  公开（公告）日：1978-09-26

  New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

  新的氨基酸取代酰基衍生物具有一般式##STR1##，可用作血管紧张素转换酶抑制剂。
• Alanine 2, 6-dialkoxyphenyl ester derivatives as hypnotics
  申请人：——

  公开号：US20040059109A1

  公开（公告）日：2004-03-25

  The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I, Formula (I) wherein R 1 is (C 1-3 )alkyloxy, (C 1-3 )alkyloxy(C 1-3 )alkyl, (C 1-3 )alkylthio, (C 1-3 )alkylthio(C 1-3 )alkyl, (C 1-3 )alkylsulfinyl, (C 1-3 )alkylsulfinyl(C 1-3 )alkyl, (C 1-3 )alkylsulfonyl, (C 1-3 )alkylsulfonyl(C 1-3 )alkyl, (C 1-3 )alkyloxycarbonyl, (CH 2 ) n —CO—NR 8 R 9? or (CH2) n —NR 8 R 9?; n is 0, 1 or 2; R 2 is hydrogen or (C 1-3?)alkyl; R 3 is (C 1-3 )alkyl or (C 1-3 )alkyloxy(C 1-3?)alkyl; R 4 is (C 1-3 )alkyloxy(C 1-3 )alkyl; or R 3 and R 4 form together with the nitrogen atom to which they are bound a 5-, 6-, or 7-membered ring, optionally containing a further heteroatom selected from O and S, and which ring may optionally contain a double bond and be optionally substituted with (C 1-3 )alkyl or (C 1-3 )alkyloxy; R 5 and R 6 are independently (C 1-3 )alkyl; R 7 is hydrogen, (C 1-3 )alkyl, (C 1-3 )alkyloxy or (C 2-3 )alkenyl; R 8 and R 9 are independently (C 1-3 )alkyl; or R 8 and R 9 form together with the nitrogen atom to which they are bound a 5-, 6-, or 7-membered, optionally containing a further heteroatom selected from O and S, and which ring may optionally contain a double bond; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of these alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics for the induction and maintenance of general anaesthesia. 1

  本发明涉及具有一般式I的丙氨酸2,6-二烷氧基苯酯衍生物，式(I)其中，R1是(C1-3)烷氧基、(C1-3)烷氧基(C1-3)烷基、(C1-3)烷基硫醚、(C1-3)烷基硫醚(C1-3)烷基、(C1-3)烷基亚磺酰、(C1-3)烷基亚磺酰(C1-3)烷基、(C1-3)烷基磺酰、(C1-3)烷基磺酰(C1-3)烷基、(C1-3)烷氧羰基、(CH2)n—CO—NR8R9或(CH2)n—NR8R9；n为0、1或2；R2是氢或(C1-3)烷基；R3是(C1-3)烷基或(C1-3)烷氧基(C1-3)烷基；R4是(C1-3)烷氧基(C1-3)烷基；或R3和R4与它们所结合的氮原子一起形成一个5、6或7元环，可选地含有进一步从O和S中选择的杂原子，并且该环可以可选地含有双键并被(C1-3)烷基或(C1-3)烷氧基取代；R5和R6独立地是(C1-3)烷基；R7是氢、(C1-3)烷基、(C1-3)烷氧基或(C2-3)烯基；R8和R9独立地是(C1-3)烷基；或者R8和R9与它们所结合的氮原子一起形成一个5、6或7元环，可选地含有进一步从O和S中选择的杂原子，并且该环可以可选地含有双键；或其药学上可接受的盐。本发明还涉及包含上述衍生物的制药组合物，以及将这些丙氨酸2,6-二烷氧基苯酯衍生物用作诱导和维持全身麻醉的催眠药的用途。
• Total synthesis of (±)-fluorocurarine, the racemate of a Calabash-curare alkaloid
  作者：G. C. Crawley、John Harley-Mason

  DOI：10.1039/c29710000685

  日期：——

  We report a total synthesis of (±)-fluorocurarine iodide in eleven stages from tryptamine.

  我们报告了从色胺的11个阶段的（±）-氟尿嘧啶碘的总合成。