N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(R)-phenyl-4-piperidinylmethyl]amino]-1(2H)-pyrazinyl]-benzamide | 1095003-10-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(R)-phenyl-4-piperidinylmethyl]amino]-1(2H)-pyrazinyl]-benzamide
• 英文别名: N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(R)-phenyl(piperidin-4-yl)methyl]amino]pyrazin-1-yl]benzamide
• CAS: 1095003-10-3
• 化学式: C₂₇H₃₁N₅O₂
• 分子量: 457.575
• InChiKey: DHFQKNVXFWPWMO-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  85.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基-4-甲基苯甲酸甲酯 在 palladium 10% on activated carbon 1,4-环己二烯 、 N,N-二异丙基乙胺 、 环戊基溴化镁 作用下， 以 四氢呋喃 、 乙醚 、 邻二氯苯 、 叔丁醇 为溶剂， 反应 18.0h， 生成 N-cyclopropyl-4-methyl-3-[2-oxo-3-[[(R)-phenyl-4-piperidinylmethyl]amino]-1(2H)-pyrazinyl]-benzamide 、 4-[(R)-[[4-[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]-3,4-dihydro-3-oxopyrazinyl]amino]phenylmethyl]-1-piperidinecarboxylic acid, phenyl ester
  参考文献：
  名称：

  WO2009/1132

  摘要：

  公开号：

文献信息

• Compounds and their uses 708
  申请人：AstraZeneca AB

  公开号：US08163905B2

  公开（公告）日：2012-04-24

  The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的吡嗪酮衍生物，其中R1，R2，R3，R4，R5，R6和R7如本文所定义；其制备过程，包含它们的药物组合物以及它们在治疗中的使用。
• COMPOUNDS AND THEIR USES 708
  申请人：BROUGH Stephen

  公开号：US20120065214A1

  公开（公告）日：2012-03-15

  The present invention relates to pyrazinone derivatives of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及公式（I）的吡唑酮衍生物：其中R1、R2、R3、R4、R5、R6和R7如本文所定义；其制备过程，含有它们的制药组合物以及它们在治疗中的应用。
• N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2- [(2-hydroxethyl)amino] ethoxy]phenyl] cyclopropyl] amino]-2-oxo-1 (2H)-pyrazinyl]-4-methyl-benzamide, or pharmaceutically acceptable salts thereof and their uses
  申请人：AstraZeneca AB

  公开号：US08299246B2

  公开（公告）日：2012-10-30

  The present invention relates to pyrazinone derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的吡嗪酮衍生物，其中R1、R2、R3、R4、R5、R6和R7如本文所定义；它们的制备方法、含有它们的制药组合物以及它们在治疗中的应用。
• N-CYCLOPROPYL-3-FLUORO-5-[3-[[1-[2-[2- [(2-HYDROXETHYL)AMINO] ETHOXY]PHENYL] CYCLOPROPYL] AMINO]-2-OXO- 1 (2H)-PYRAZINYL]-4-METHYL-BENZAMIDE, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND THEIR USES
  申请人：Brough Stephen

  公开号：US20120214822A1

  公开（公告）日：2012-08-23

  The present invention relates to pyrazinone derivatives of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式（I）的吡唑酮衍生物，其中R1，R2，R3，R4，R5，R6和R7如本文所定义；其制备方法，含有它们的制药组合物，以及它们在治疗中的用途。
• PYRAZINONE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND THEIR USES
  申请人：Brough Stephen

  公开号：US20130012523A1

  公开（公告）日：2013-01-10

  The present invention relates to pyrazinone derivatives of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的吡嗪酮衍生物，其中R1，R2，R3，R4，R5，R6和R7如所定义;它们的制备方法，含有它们的制药组合物以及它们在治疗中的使用。