N'-(tert-butyl)-3,5-dichlorobenzohydrazide | 112226-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(tert-butyl)-3,5-dichlorobenzohydrazide
• 英文别名: N'-tert-butyl-3,5-dichlorobenzohydrazide
• CAS: 112226-07-0
• 化学式: C₁₁H₁₄Cl₂N₂O
• 分子量: 261.151
• InChiKey: BFWQRPRGIUXIJU-UHFFFAOYSA-N

物化性质

• 熔点：
  163-165 °C
• 沸点：
  339.6±42.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methyl-1,2,3-thiadiazole-4-carbonyl chloride 、 N'-(tert-butyl)-3,5-dichlorobenzohydrazide 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以48%的产率得到
  参考文献：
  名称：

  Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides

  摘要：

  A series of novel N-tert-butyl-N'-acyl-5-methyl-1,2,3-thiadiazole-4-carbohyclrazides were designed and synthesized. Their structures were characterized by melting points, H-1 NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in viva at 50 mu g/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. (C) 2012 Zhi Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.09.024
• 作为产物：
  描述：

  3,5-二氯苯甲酸 在 氯化亚砜 、 水 、 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 N'-(tert-butyl)-3,5-dichlorobenzohydrazide
  参考文献：
  名称：

  Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides

  摘要：

  A series of novel N-tert-butyl-N'-acyl-5-methyl-1,2,3-thiadiazole-4-carbohyclrazides were designed and synthesized. Their structures were characterized by melting points, H-1 NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in viva at 50 mu g/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. (C) 2012 Zhi Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.09.024

文献信息

• Synthesis and Bioactivities Evaluation of Novel Anthranilic Diamides Containing <i>N</i> ‐( <i>tert</i> ‐Butyl)benzohydrazide Moiety as Potent Ryanodine Receptor Activator
  作者：Yunyun Zhou、Wei Wei、Liangliang Zhu、Yuxin Li

  DOI：10.1002/cjoc.201900073

  日期：2019.6

  Anthranilic diamides have been proven to be a class of efficacious and safe insecticides targeting ryanodine receptors (RyRs) during the last decade. In order to develop innovative scaffolds with high insecticidal activity, two series of N‐pyridylpyrazole derivatives containing N‐(tert‐butyl)benzohydrazide substructures were designed and synthesized. Their insecticidal activities against oriental armyworm

  在过去的十年中，邻氨基苯甲酰胺已被证明是针对瑞丹素受体（RyRs）的一类有效且安全的杀虫剂。为了开发具有高杀虫活性的创新支架，设计并合成了两个包含N-（叔丁基）苯并肼亚结构的N-吡啶基吡唑衍生物系列。它们对东方粘虫（Mythimna separata）和小菜蛾（Plutella xylostella）具有杀虫活性。）进行了评估。初步的生物测定结果表明，某些新化合物对东方粘虫和小菜蛾具有良好的杀虫活性。这些化合物的作用方式已通过钙显像技术进行了验证，结果表明，一些新化合物可以有效调节昆虫胞浆中的Ca 2+水平，并破坏细胞内钙稳态，表明其中某些化合物是该化合物的有效激活剂。 RyRs。
• ADDOR, R. W.;KUHN, D. G.;WRIGHT, D. P. (JR)
  作者：ADDOR, R. W.、KUHN, D. G.、WRIGHT, D. P. (JR)

  DOI：——

  日期：——
• Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides
  作者：Wu Tao Mao、Hui Zhao、Zhi Jin Fan、Xiao Tian Ji、Xue Wen Hua、Tatiana Kalinina、Yu. Morzherin Yury、A. Bakulev Vasiliy

  DOI：10.1016/j.cclet.2012.09.024

  日期：2012.11

  A series of novel N-tert-butyl-N'-acyl-5-methyl-1,2,3-thiadiazole-4-carbohyclrazides were designed and synthesized. Their structures were characterized by melting points, H-1 NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in viva at 50 mu g/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development. (C) 2012 Zhi Jin Fan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.