6-methoxypyrazine-2-carboxylic acid (bis-methylsulfanylmethylene)hydrazide | 929038-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-methoxypyrazine-2-carboxylic acid (bis-methylsulfanylmethylene)hydrazide
• 英文别名: N'-[bis(methylsulfanyl)-methylidene]-6-methoxypyrazine-2-carbohydrazide；N'-[Bis(methylsulfanyl)methylidene]-6-methoxypyrazine-2-carbohydrazide；N-[bis(methylsulfanyl)methylideneamino]-6-methoxypyrazine-2-carboxamide
• CAS: 929038-95-9
• 化学式: C₉H₁₂N₄O₂S₂
• 分子量: 272.352
• InChiKey: WDZKDEHJBWLYRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-methoxypyrazine-2-carboxylic acid (bis-methylsulfanylmethylene)hydrazide 、 二甲基丙二胺 以 二乙二醇二甲醚 为溶剂， 反应 8.0h， 以40%的产率得到2-methoxy-6-(5-methylsulfanyl-[1,3,4]oxadiazol-2-yl)pyrazine
  参考文献：
  名称：

  Studies on Pyrazine Derivatives. XLIX. Synthesis and Antibacterial Activity of 6-Methoxypyrazine-2-carboxylic Acid Hydrazide Derivatives

  摘要：

  The new 6-methoxy-pyrazine derivatives have been synthesized. 6-Methoxy-pyrazine-2-carboxylic acid hydrazide was used as an initial material to obtain mono- and dithioester of hydrazinecarbodithioic acid (2 and 3). Compound (2) in reaction with ethanolamine gave triazole derivative (8) with beta-hydoxyethyl substituent in 4-position and hydroxyl group in 6-position of pyrazine ring. Dithioester (3) in a reaction with morpholine cyclized to 1,3,4-oxadiazole (11). The same substrate with alkyldiamines gave the few following derivatives: 1,3-diazacycloalkane derivatives (9 and 10), S-methyl-1,3,4-oxadiazole derivative (12) and 1,2,4-triazoletetrahydropyrimidine (13). The compounds obtained were tested in vitro for their activity towards pathogenic strains of anaerobic and aerobic bacteria. Derivative (9) was the most active against both types of tested strains.

  DOI：

  10.3987/com-06-10867
• 作为产物：
  描述：

  二硫化碳 、 6-甲氧基吡嗪-2-碳酰肼 、 碘甲烷 在 氢氧化钾 、 水 作用下， 以 乙醇 、 水 为溶剂， 反应 0.75h， 以47%的产率得到6-methoxypyrazine-2-carboxylic acid (bis-methylsulfanylmethylene)hydrazide
  参考文献：
  名称：

  Studies on Pyrazine Derivatives. XLIX. Synthesis and Antibacterial Activity of 6-Methoxypyrazine-2-carboxylic Acid Hydrazide Derivatives

  摘要：

  The new 6-methoxy-pyrazine derivatives have been synthesized. 6-Methoxy-pyrazine-2-carboxylic acid hydrazide was used as an initial material to obtain mono- and dithioester of hydrazinecarbodithioic acid (2 and 3). Compound (2) in reaction with ethanolamine gave triazole derivative (8) with beta-hydoxyethyl substituent in 4-position and hydroxyl group in 6-position of pyrazine ring. Dithioester (3) in a reaction with morpholine cyclized to 1,3,4-oxadiazole (11). The same substrate with alkyldiamines gave the few following derivatives: 1,3-diazacycloalkane derivatives (9 and 10), S-methyl-1,3,4-oxadiazole derivative (12) and 1,2,4-triazoletetrahydropyrimidine (13). The compounds obtained were tested in vitro for their activity towards pathogenic strains of anaerobic and aerobic bacteria. Derivative (9) was the most active against both types of tested strains.

  DOI：

  10.3987/com-06-10867

文献信息

• Studies on Pyrazine Derivatives. XLIX. Synthesis and Antibacterial Activity of 6-Methoxypyrazine-2-carboxylic Acid Hydrazide Derivatives
  作者：Katarzyna Gobis、Henryk Foks、Aleksandra Zuralska、Anna Kedzia

  DOI：10.3987/com-06-10867

  日期：——

  The new 6-methoxy-pyrazine derivatives have been synthesized. 6-Methoxy-pyrazine-2-carboxylic acid hydrazide was used as an initial material to obtain mono- and dithioester of hydrazinecarbodithioic acid (2 and 3). Compound (2) in reaction with ethanolamine gave triazole derivative (8) with beta-hydoxyethyl substituent in 4-position and hydroxyl group in 6-position of pyrazine ring. Dithioester (3) in a reaction with morpholine cyclized to 1,3,4-oxadiazole (11). The same substrate with alkyldiamines gave the few following derivatives: 1,3-diazacycloalkane derivatives (9 and 10), S-methyl-1,3,4-oxadiazole derivative (12) and 1,2,4-triazoletetrahydropyrimidine (13). The compounds obtained were tested in vitro for their activity towards pathogenic strains of anaerobic and aerobic bacteria. Derivative (9) was the most active against both types of tested strains.