2-bromo-2-methyl-propionic acid 2-(3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl ester | 1069117-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-bromo-2-methyl-propionic acid 2-(3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl ester
• 英文别名: 2-Bromo-2-methyl-propionic acid 2-(3,5-dioxo-10-oxa-4azatricyclo[5.2.1.02,6]dec-8-en-4-yl)ethyl ester；2-(1,3-dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)ethyl 2-bromo-2-methylpropanoate
• CAS: 1069117-44-7
• 化学式: C₁₄H₁₆BrNO₅
• 分子量: 358.189
• InChiKey: YPYVPGHEOXQIIF-UHFFFAOYSA-N

物化性质

• 沸点：
  502.6±50.0 °C(Predicted)
• 密度：
  1.569±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4,10-二氧杂三环[5.2.1.0(2,6)]癸-8-烯-3,5-二酮 在 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.0h， 生成 2-bromo-2-methyl-propionic acid 2-(3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-ethyl ester
  参考文献：
  名称：

  Formation of giant amphiphiles by post-functionalization of hydrophilic protein–polymer conjugates

  摘要：

  我们设计并开发了一种新型通用方法，用于合成三嵌段蛋白质聚合物巨型双亲化合物家族。我们通过原子转移自由基聚合（ATRP）合成了一种亲水性δ-马来酰亚胺基聚-1-炔，Mn = 9.5 kDa（1H-NMR），PDi 很窄（SEC 测量为 1.15）。这种聚合物与 BSA 成功耦合，产生了一种亲水性多功能生物共轭物，并利用蛋白质纯化技术对其进行了分离和全面表征。按照后官能化的方法，我们通过一个简单、高产的 "clickâ-chemistry cycloaddition "步骤，将疏水性引入到所得到的亲水性生物杂交体中。分离出的三嵌段蛋白质聚合物两亲物显示出有趣的聚集模式（TEM、共聚焦显微镜）。

  DOI：

  10.1039/b618079e

文献信息

• Light-induced modification of silver nanoparticles with functional polymers
  作者：Lukas Stolzer、Ishtiaq Ahmed、Cesar Rodriguez-Emmenegger、Vanessa Trouillet、Pascal Bockstaller、Christopher Barner-Kowollik、Ljiljana Fruk

  DOI：10.1039/c4cc00960f

  日期：——

  Light coating: Ag–polymer core–shell nanoparticles were prepared using photoenol-based light-induced ligation.

  轻涂层：使用基于光诱导的烯醇的方法制备了Ag-聚合物核-壳纳米颗粒。
• [EN] POLYMERIC NANOPARTICLES FOR ULTRASOUND IMAGING AND THERAPY<br/>[FR] NANOPARTICULES POLYMÈRES UTILISÉES POUR L'IMAGERIE ET LE TRAITEMENT PAR ULTRASONS
  申请人：UNIV MICHIGAN

  公开号：WO2013055791A1

  公开（公告）日：2013-04-18

  Provided herein are nanobubbles designed for use in ultrasound-mediated ablation of cancer cells. The nanobubbles undergo ultrasound-mediated cavitation at an ablation threshold which is significantly decreased, relative to standard ultrasound- mediated treatment of cancer cells. In exemplary embodiments, the nanobubbles comprise an amphiphilic ABC triblock copolymer, wherein block A comprises a hydrophilic polymer, block B comprises a crosslinking polymer, and block C comprises a hydrophobic copolymer comprising (i) methyl methacrylate (MMA) and (ii) a fluorinated monomer, wherein the fluorinated monomer is present in the hydrophobic copolymer of block C at 25 mole percent or less. Related treatment and diagnostic methods, as well as materials relating to the nanobubbles are provided herein. Methods of making a random copolymer are furthermore provided herein.

  本文提供了设计用于超声介导癌细胞消融的纳米气泡。这些纳米气泡在消融阈值下经历超声介导的空化作用，相对于标准的超声介导癌细胞治疗，其消融阈值显著降低。在示范性实施例中，这些纳米气泡包括一种两性ABC三嵌段共聚物，其中嵌段A包括一个亲水性聚合物，嵌段B包括一个交联聚合物，而嵌段C包括一个亲脂性共聚物，包括(i) 甲基丙烯酸甲酯（MMA）和(ii) 一种氟化单体，其中氟化单体以25摩尔%或更低的比例存在于嵌段C的亲脂性共聚物中。此外，本文还提供了与纳米气泡相关的治疗和诊断方法，以及相关材料。此外，本文还提供了制备随机共聚物的方法。
• Polymeric nanoparticles for ultrasound imaging and therapy
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US09415123B2

  公开（公告）日：2016-08-16

  Provided herein are nanobubbles designed for use in ultrasound-mediated ablation of cancer cells. The nanobubbles undergo ultrasound-mediated cavitation at an ablation threshold which is significantly decreased, relative to standard ultrasound-mediated treatment of cancer cells. In exemplary embodiments, the nanobubbles comprise an amphiphilic ABC triblock copolymer, wherein block A comprises a hydrophilic polymer, block B comprises a crosslinking polymer, and block C comprises a hydrophobic copolymer comprising (i) methyl methacrylate (MMA) and (ii) a fluorinated monomer, wherein the fluorinated monomer is present in the hydrophobic copolymer of block C at 25 mole percent or less. Related treatment and diagnostic methods, as well as materials relating to the nanobubbles are provided herein. Methods of making a random copolymer are furthermore provided herein.

  本文提供了用于超声波介导的癌细胞消融的纳米气泡。相对于标准的超声波介导癌细胞治疗，这些纳米气泡在消融阈值上显著降低。在示范实施中，纳米气泡包括一种两性ABC三嵌段共聚物，其中块A包括一种亲水性聚合物，块B包括一种交联聚合物，块C包括一种疏水性共聚物，包括（i）甲基丙烯酸甲酯（MMA）和（ii）一种氟化单体，其中氟化单体在块C的疏水性共聚物中的摩尔百分比为25％或以下。本文还提供了相关的治疗和诊断方法，以及与纳米气泡相关的材料。此外，本文还提供了制备随机共聚物的方法。
• Polymer
  申请人：Haddleton David

  公开号：US20080300348A1

  公开（公告）日：2008-12-04

  The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerisation of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer. Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

  该应用程序提供了一种生产梳状聚合物的方法，包括以下步骤：(a) 提供：(i) 一种具有烯丙基不饱和基团的线性、支化或星形单体，取代或非取代，该烯丙基不饱和基团能够进行加成聚合；(ii) 一种引发剂化合物；该引发剂化合物包括一个均裂性可裂解键。(iii) 一种催化剂，能够催化单体的聚合；以及(b) 使催化剂与引发剂相结合，催化多种单体的聚合，从而产生梳状聚合物。该过程获得的催化剂和聚合物也被提供。优选地，该梳状聚合物能够结合蛋白质，并且可以由烷氧基聚醚单体制成，例如聚(烷基二醇)或聚四氢呋喃。
• Polymeric Nanoparticles for Ultrasound Imaging and Therapy
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20140243664A1

  公开（公告）日：2014-08-28

  Provided herein are nanobubbles designed for use in ultrasound-mediated ablation of cancer cells. The nanobubbles undergo ultrasound-mediated cavitation at an ablation threshold which is significantly decreased, relative to standard ultrasound-mediated treatment of cancer cells. In exemplary embodiments, the nanobubbles comprise an amphiphilic ABC triblock copolymer, wherein block A comprises a hydrophilic polymer, block B comprises a crosslinking polymer, and block C comprises a hydrophobic copolymer comprising (i) methyl methacrylate (MMA) and (ii) a fluorinated monomer, wherein the fluorinated monomer is present in the hydrophobic copolymer of block C at 25 mole percent or less. Related treatment and diagnostic methods, as well as materials relating to the nanobubbles are provided herein. Methods of making a random copolymer are furthermore provided herein.

  本文提供了一种设计用于超声波介导的癌细胞消融的纳米气泡。相较于标准的超声波介导癌细胞治疗，这些纳米气泡在消融阈值上经历了超声波介导空化的显著降低。在示例实施方案中，纳米气泡包括一种两性ABC三嵌段共聚物，其中块A包括一种亲水性聚合物，块B包括一种交联聚合物，而块C则包括一种疏水性共聚物，该疏水性共聚物包括(i)甲基丙烯酸甲酯(MMA)和(ii)一种氟化单体，其中该氟化单体在块C的疏水性共聚物中的摩尔分数为25%或更少。本文还提供了相关的治疗和诊断方法，以及与纳米气泡相关的材料。此外，本文还提供了一种制备随机共聚物的方法。