2-溴-4-氯噻吩并[3,2-c]吡啶 | 28948-61-0

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 中文名称: 2-溴-4-氯噻吩并[3,2-c]吡啶
• 中文别名: 2-溴-4-氯噻吩并[3,2-C]吡啶；2-溴-4-氯噻吩[3,2-c]吡啶
• 英文名称: 2-bromo-4-chlorothieno[3,2-c]pyridine
• CAS: 28948-61-0
• 化学式: C₇H₃BrClNS
• 分子量: 248.531
• InChiKey: QPGCPWZFCLBFCG-UHFFFAOYSA-N

物化性质

• 熔点：
  119 °C
• 沸点：
  355.2±37.0 °C(Predicted)
• 密度：
  1.849±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2934999090

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 2-Bromo-4-chlorothieno[3,2-c]pyridine
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 2-Bromo-4-chlorothieno[3,2-c]pyridine
CAS number: 28948-61-0

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H3BrClNS
Molecular weight: 248.5

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen bromide, sulfur
oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-溴-4-氯噻吩并[3,2-c]吡啶 在 正丁基锂 、 二氧化硫 作用下， 以 乙醚 、 正己烷 、 氮气 为溶剂， 反应 4.0h， 以74%的产率得到lithium 4-chlorothieno[3,2-c]pyridine-2-sulfinate
  参考文献：
  名称：

  [EN] NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS
  [FR] COMPOSES UTILES POUR LE TRAITEMENT DE L'OBESITE, DU DIABETE DE TYPE II ET DES TROUBLES DU SYSTEME NERVEUX CENTRAL

  摘要：

  本发明涉及一般式（I）的化合物，其中P为砜或磺酰胺；A、B、W、X、Y和R3如描述中定义；含有这些化合物的药物组合物；以及利用这些化合物预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病有关的医疗状况，以实现减轻体重和减少体重增加。

  公开号：

  WO2004000828A1
• 作为产物：
  描述：

  2-溴噻吩并[3,2-c]吡啶-4(5H)-酮 在 三氯氧磷 作用下， 反应 2.5h， 以80.7%的产率得到2-溴-4-氯噻吩并[3,2-c]吡啶
  参考文献：
  名称：

  [EN] NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS
  [FR] COMPOSES UTILES POUR LE TRAITEMENT DE L'OBESITE, DU DIABETE DE TYPE II ET DES TROUBLES DU SYSTEME NERVEUX CENTRAL

  摘要：

  本发明涉及一般式（I）的化合物，其中P为砜或磺酰胺；A、B、W、X、Y和R3如描述中定义；含有这些化合物的药物组合物；以及利用这些化合物预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病有关的医疗状况，以实现减轻体重和减少体重增加。

  公开号：

  WO2004000828A1

文献信息

• Inhibitors of CYP 17
  申请人：BOCK Mark G.

  公开号：US20100331326A1

  公开（公告）日：2010-12-30

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了式(I)和(II)的化合物，或其药用可接受的盐， 其中R 53 ，R 54 ，p，q和n如本文所述定义。本发明的化合物被发现作为17α-羟化酶/C 17,20 -裂解酶抑制剂是有用的。
• [EN] BICYCLIC HETEROARYL COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLE BICYCLIQUES ET LEURS UTILISATIONS
  申请人：REVOLUTION MEDICINES INC

  公开号：WO2020180768A1

  公开（公告）日：2020-09-10

  The present disclosure is directed to modulators of SOS1 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.

  本公开涉及SOS1的调节剂及其在治疗疾病中的应用。还公开了包含相同成分的药物组合物。
• Synthesis and Study the Effect of Donor-Acceptor Substituent on Fluorescence Behavior of Thieno[3, 2-c]pyridine Derivatives
  作者：Raghunath B. Toche、Sunil N. Chavan

  DOI：10.1007/s10895-013-1313-8

  日期：2014.3

  4-Hetero-1-yl-2-bromothieno[3,2-c]pyridines 3(a–d) were synthesized by the reaction of 2-bromo-4-chlorothieno[3,2-c]pyridine (1) and cyclic amine 2(a–d), which on Suzuki coupling with substituted boronic acids 4(a–f) exclusively converted to corresponding 4-hetero -1-yl-2-arylthieno[3,2-c]pyridine 5(a–x) in good yields. The effect of donor-acceptor substituent on absorption emission properties and

  4-杂-1-基-2-溴噻吩并[3,2-c]吡啶3(a-d)是通过2-溴-4-氯噻吩并[3,2-c]吡啶(1)和环胺2(a-d)，在Suzuki与取代硼酸4(a-f)偶联时仅转化为相应的 4-杂-1-基-2-芳基噻吩 [3,2-c]吡啶5(a- x)收益良好。研究了供体-受体取代基对新型噻吩并吡啶衍生物5(ax) 的吸收发射特性和荧光量子产率的影响。
• INHIBITORS OF CYP 17
  申请人：BOCK Mark Gary

  公开号：US20140228394A1

  公开（公告）日：2014-08-14

  The present invention provides compounds of Formula (I) and (II), or a pharmaceutically acceptable salts thereof, where R 53 , R 54 , p, q, and n are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C 17,20 -lyase inhibitors.

  本发明提供了公式(I)和(II)化合物，或其药学上可接受的盐，其中R53、R54、p、q和n的定义如本文所述。本发明的化合物已被发现可以作为17α-羟化酶/C17,20-裂解酶抑制剂使用。
• Cell adhesion-inhibiting antiinflammatory compounds
  申请人：——

  公开号：US20010020030A1

  公开（公告）日：2001-09-06

  Compounds having Formula I 1 are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

  具有I1式的化合物对于治疗炎症有用。本文还公开了包含I式化合物的制药组合物，以及在哺乳动物中抑制/治疗炎症性疾病的方法。