DISULFIDE COMPOUNDS FOR DELIVERY OF PHARMACEUTICAL AGENTS
申请人:XU Qiaobing
公开号:US20160009643A1
公开(公告)日:2016-01-14
A compound of formula the following formula: (I). In this formula, moieties A, B, X, R
1
, R
2
, and R
3
are defined herein. Also disclosed are a nanocomplex that is formed of such a compound and a pharmaceutical agent, and a nanocomplex that is formed of a protein and a bioreducible compound.
NANOCOMPLEXES FOR DELIVERY OF SAPORIN
申请人:TUFTS UNIVERSITY
公开号:US20160082126A1
公开(公告)日:2016-03-24
A nanocomplex, of particle size 50 nm to 1000 nm, containing saporin and a lipid-like compound, in which saporin binds to the lipid-like compound via non-covalent interaction or covalent bonding. The lipid-like compound has a hydrophilic moiety, a hydrophobic moiety, and a linker joining the hydrophilic moiety and the hydrophobic moiety. The hydrophilic moiety is optionally charged and the hydrophobic moiety has 8 to 24 carbon atoms. Also disclosed is a pharmaceutical composition containing such a nanocomplex and a pharmaceutically acceptable carrier. The nanocomplex is useful in treating diseases, such as cancer.