tert-butyl N-[(2E)-2-[[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]-1-phenylpentyl]carbamate | 1204391-09-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[(2E)-2-[[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]-1-phenylpentyl]carbamate
• CAS: 1204391-09-2
• 化学式: C₂₂H₃₄N₂O₄
• 分子量: 390.523
• InChiKey: OCSBLQDIABKFTQ-BMRADRMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl N-pent-1-enylcarbamate 、 benzaldehyde N-boc imine 在 三甲基氯硅烷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 、 tert-butyl N-[(2E)-2-[[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]-1-phenylpentyl]carbamate
  参考文献：
  名称：

  Trimethylchlorosilane-promoted aza-Mannich reaction of enecarbamates and aldimines

  摘要：

  A trimethylchlorosilane-promoted aza-Mannich reaction is reported utilizing enecarbamates as the nucleophile and aromatic N-Boc aldimines as the electrophile. A variety of nucleophiles and electrophiles are tolerated by the reaction conditions, delivering the adduct products in excellent yields with high E-stereoselectivities. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.097

文献信息

• Trimethylchlorosilane-promoted aza-Mannich reaction of enecarbamates and aldimines
  作者：Pengcheng Wu、Deqin Lin、Xiaoxia Lu、Li Zhou、Jian Sun

  DOI：10.1016/j.tetlet.2009.09.097

  日期：2009.12

  A trimethylchlorosilane-promoted aza-Mannich reaction is reported utilizing enecarbamates as the nucleophile and aromatic N-Boc aldimines as the electrophile. A variety of nucleophiles and electrophiles are tolerated by the reaction conditions, delivering the adduct products in excellent yields with high E-stereoselectivities. (C) 2009 Elsevier Ltd. All rights reserved.