24-methyl-3-β-9,19-cyclolanost-24-en-3-ol | 25692-13-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-methyl-3-β-9,19-cyclolanost-24-en-3-ol
• 英文别名: cyclobranol；24-methyl-cycloartenol；(1S,3R,6S,8R,11S,12S,15R,16R)-15-[(2R)-5,6-dimethylhept-5-en-2-yl]-7,7,12,16-tetramethylpentacyclo[9.7.0.01,3.03,8.012,16]octadecan-6-ol
• CAS: 25692-13-1
• 化学式: C₃₁H₅₂O
• 分子量: 440.753
• InChiKey: CIBNJPPYSPYHDB-UEBIAWITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  对硝基苯甲酸 、 氯化亚砜 、 24-methyl-3-β-9,19-cyclolanost-24-en-3-ol 在 1,4-二氧六环 、 吡啶 、 氯仿 、 disodium;carbonate 、 水 、 Brine 、 乙醇 、 乙酸乙酯 作用下， 以 1,4-二氧六环 为溶剂， 反应 4.0h， 以giving cyclobranol-p-nitrobenzoate (2.28 g) in a 90% yield的产率得到Cyclobranol p-nitrobenzoate
  参考文献：
  名称：

  Triterpenyl esters of organic acids and hypolipidemic agents composed of

  摘要：

  一种有机酸的三萜酯，不包括对香豆酸、单基和二元饱和脂肪酸的三萜酯。制备该有机酸的三萜酯的方法包括将三萜醇与相应有机酸的酸卤反应。一种用于治疗高脂血症的制药组合物，包括制药载体和有效量的除二元饱和脂肪酸三萜酯外的有机酸三萜酯。一种用于治疗高脂血症的制药组合物，包括制药载体和环戊三萜烯作为活性成分。

  公开号：

  US04748161A1
• 作为产物：
  描述：

  环鸦片甾烯醇 在 lithium 、 乙二胺 作用下， 反应 6.0h， 生成 24-methyl-3-β-9,19-cyclolanost-24-en-3-ol
  参考文献：
  名称：

  Higher isoprenoids—III

  摘要：

  DOI：

  10.1016/s0040-4020(01)90859-2

文献信息

• Cyclosadol, Isocyclosadol, and Other Related Triterpene Alcohols Obtained from 24-Methylenecycloartanol by Acid-catalyzed Isomerization
  作者：Naoto Shimizu、Toshihiro Itoh、Yoshiyuki Ichinohe、Taro Matsumoto

  DOI：10.1246/bcsj.57.1425

  日期：1984.5

  The acid-catalyzed isomerization of 24-methylenecycloartanol with sulfuric acid afforded cyclosadol (23E-Δ23), isocyclosadol (23Z-Δ23), and other isomers, including lanostane- and cucurbitane-type isomers with (23E)- and (23Z)-Δ23- and Δ24-unsaturated side chains. The phytochemical significance of the isomers is discussed.

  24-亚甲基环木松醇与硫酸的酸催化异构化得到环沙多醇 (23E-Δ23)、异环沙多醇 (23Z-Δ23) 和其他异构体，包括具有 (23E)- 和 (23Z)-Δ23 的羊毛甾烷和葫芦烷型异构体- 和 Δ24-不饱和侧链。讨论了异构体的植物化学意义。
• Compositions and methods for treatment of mammalian skin
  申请人：Berry Don Wayne

  公开号：US20110086088A1

  公开（公告）日：2011-04-14

  Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant melanoma, and radiation-induced burns. In some embodiments the treatments comprise contacting human or other mammalian skin with a composition according to the disclosure. In other embodiments, administration of compositions provided is by injection. Some embodiments provide for preventive use of compositions provided towards preventing some forms of skin cancer and skin cancer-related disorders by repeated application to healthy-looking skin. Methods for providing the compositions are disclosed.
• Compositions and methods for treatment on mammalian skin
  申请人：BERRY PHARMACEUTICALS, L.L.C.

  公开号：US20140193478A1

  公开（公告）日：2014-07-10

  Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant melanoma, and radiation-induced burns. In some embodiments the treatments comprise contacting human or other mammalian skin with a composition according to the disclosure. In other embodiments, administration of compositions provided is by injection. Some embodiments provide for preventive use of compositions provided towards preventing some forms of skin cancer and skin cancer-related disorders by repeated application to healthy-looking skin. Methods for providing the compositions are disclosed.
• US8652534B2
  申请人：——

  公开号：US8652534B2

  公开（公告）日：2014-02-18
• US9345736B2
  申请人：——

  公开号：US9345736B2

  公开（公告）日：2016-05-24