(7S,8R,11S)-nonacosane-7,8,11-triol | 1453495-16-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (7S,8R,11S)-nonacosane-7,8,11-triol
• CAS: 1453495-16-3
• 化学式: C₂₉H₆₀O₃
• 分子量: 456.794
• InChiKey: RDSTXMQHTKEKLS-YTCPBCGMSA-N

物化性质

• 沸点：
  585.7±30.0 °C(predicted)
• 密度：
  0.911±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  32
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (7S,8R,11S)-nonacosane-7,8,11-triol 、 甲氧基-三氟甲基苯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Two new nonacosanetriols from Ginkgo biloba sarcotesta

  摘要：

  Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2012.08.003

文献信息

• Two new nonacosanetriols from Ginkgo biloba sarcotesta
  作者：Guisheng Zhou、Xin Yao、Yuping Tang、Nianyun Yang、Hanqing Pang、Xuan Mo、Shaoqing Zhu、Shulan Su、Dawei Qian、Chun Jin、Yong Qin、Jin-ao Duan

  DOI：10.1016/j.chemphyslip.2012.08.003

  日期：2012.10

  Two new fatty alcohols named as (7S,8R,11S)-nonacosanetriol (1) and (10R,12R,15S)-nonacosanetriol (2), along with eight known compounds including ginkgolic acid (3), hydroginkgolic acid (4), sciadopitysin (5), ginkgetin (6), isoginkgetin (7), ginkgolide A (8), ginkgolide B (9) and ginkgolide C (10) have been isolated from the petroleum ether extract of Ginkgo biloba sarcotesta. Their structures were elucidated by means of chemical and extensive spectroscopic analysis. The absolute stereochemistry of compounds 1 and 2 was elucidated on the spectroscopic analysis of the R- and S-MTPA esters. Compounds 1 and 2 exhibited slight activity of antithrombin and moderate activity of antiplatelet aggregation in vitro. This was the first report regarding the anticoagulative activities of biflavonoids in G. biloba, and isoginkgetin (7) showed significant antithrombin and antiplatelet aggregation activity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.