甘草酸二钾盐

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 甘草酸二钾盐
• 中文别名: 甘草酸二钾盐水合物；甘草二钾盐；甘草酸二钾水合物；甘草酸二钾
• 化学式: C42H62K2O16
• 分子量: 901.1
• InChiKey: OBGGYNKAUJJJKE-VLQRKCJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.48
• 重原子数：
  60
• 可旋转键数：
  7
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  267
• 氢给体数：
  8
• 氢受体数：
  16

文献信息

• PHARMACEUTICAL COMPOSITION CONTAINING MIRABEGRON
  申请人：ASTELLAS PHARMA INC.

  公开号：US20150031734A1

  公开（公告）日：2015-01-29

  Provided is a mirabegron-containing pharmaceutical composition in which the leakage of mirabegron can be inhibited when the pharmaceutical composition is dispersed in a liquid, and in which the change in pharmacokinetics caused by the presence or absence of food intake is decreased. The pharmaceutical composition comprises an acid addition salt of alkyl sulfuric acid and mirabegron, and a base for modified release.

  提供一种含有米拉贝隆的药物组合物，当该药物组合物分散在液体中时，可以抑制米拉贝隆的泄漏，并且减少由于饮食摄入与否引起的药代动力学变化。该药物组合物包括烷基硫酸盐和米拉贝隆的酸加盐，以及用于改良释放的碱。
• Phytospingosine derivative and composition containing same
  申请人：AMOREPACIFIC CORPORATION

  公开号：US10172777B2

  公开（公告）日：2019-01-08

  The present invention relates to a phytospingosine derivative generated by a condensation reaction of phytospingosine and maltose or lactose, which is an aldose-based disaccharide, and to a composition containing the same. The phytospingosine derivative of the present invention has high solubility in water compared with phytospingosine, is easy to formulate since the stabilization problem in a solution is solved, and maintains or further enhances the antibacterial effect of phytospingosine.

  本发明涉及一种由植物神经鞘氨醇和麦芽糖或乳糖进行缩合反应生成的植物神经鞘氨醇衍生物，麦芽糖或乳糖是一种以醛糖为基础的双糖，以及含有该衍生物的组合物。与植物神经鞘氨醇相比，本发明的植物神经鞘氨醇衍生物在水中具有较高的溶解度，易于配制，因为溶液中的稳定问题得到解决，并且保持或进一步增强植物神经鞘氨醇的抗菌效果。
• Carboxybetaine and sulfobetaine and detergent composition and cosmetic containing the same
  申请人：KAO CORPORATION

  公开号：EP0649834A1

  公开（公告）日：1995-04-26

  Novel carboxybetaines and sulfobetaines are disclosed. Processes of the production of the carboxybetaines and sulfobetaines, as well as detergent compositions and cosmetics containing these compounds are also disclosed. The carboxybetaines and sulfobetaines of the present invention show excellent moisture keeping effect which provides the skin and hair with moist feeling for a prolonged period of time.

  本发明揭示了新型的羧基丙氨酸盐和磺基丙氨酸盐。本发明还揭示了制备羧基丙氨酸盐和磺基丙氨酸盐的方法，以及包含这些化合物的洗涤剂组合物和化妆品。本发明中的羧基丙氨酸盐和磺基丙氨酸盐表现出卓越的保湿效果，为皮肤和头发提供长时间的湿润感。
• Crystal and process for producing the same
  申请人：——

  公开号：US20040215023A1

  公开（公告）日：2004-10-28

  A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.

  生产2-乙氧基-1-[[2'-(1H-四唑-5-基)联苯-4-基]甲基]-1H-苯并咪唑-7-羧酸晶体的方法，其特征在于将化合物（I）或其盐溶解或悬浮于包含无水极性溶剂的溶剂中，然后结晶。该方法可以轻松去除化合物（I）或其盐中难以去除的杂质，例如锡化合物、化合物（I）的类似物和残留的有机溶剂。化合物（I）的晶体可以在工业规模上高效且容易地大量生产。
• Crystal of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and process for producing the same
  申请人：Hashimoto Hideo

  公开号：US20080182994A1

  公开（公告）日：2008-07-31

  A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.

  一种制备2-乙氧基-1-[[2'-(1H-四唑-5-基)联苯-4-基]甲基]-1H-苯并咪唑-7-羧酸晶体（化合物（I））的方法，其特征在于将化合物（I）或其盐溶解或悬浮在包含无水极性溶剂的溶剂中，并结晶。通过该方法，化合物（I）或其盐中难以去除的污染物，如锡化合物，化合物（I）的类似物和残留的有机溶剂，可以轻松去除。化合物（I）的晶体可以在工业规模上高效且容易地大量生产。