4-(dichloromethyl)pyridine hydrochloride | 138957-88-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(dichloromethyl)pyridine hydrochloride
• 英文别名: 4-(Dichloromethyl)pyridine;hydrochloride
• CAS: 138957-88-7
• 化学式: C₆H₅Cl₂N*ClH
• 分子量: 198.479
• InChiKey: PONMADGGALAFDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.98
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(dichloromethyl)pyridine hydrochloride 在 sodium hydride 作用下， 以 N,N-二甲基乙酰胺 、 乙腈 为溶剂， 反应 0.08h， 生成 3-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))cyclopropene triflate
  参考文献：
  名称：

  Synthesis of tripyridiniumylpropenyl anions from tripyridiniumylcyclopropanes and -cyclopropenes

  摘要：

  The syntheses of three stable, isolatable tripyridiniumylpropenyl anions are described. 1,2,3-Tris(4-(N-methylpyridiniumyl))propenyl anion and 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion were prepared by treating the corresponding cyclopropane with a base. 1,3-Bis(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion was prepared by nucleophilic attack of benzenesulfinate anion on 3-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))cyclopropene. Reduction of this cyclopropene gave either 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methyl)pyridiniumyl))propenyl anion or hexakis(4-(N-methylpyridiniumyl))benzene depending on the solvent used.

  DOI：

  10.1021/jo00032a044
• 作为产物：
  描述：

  4-三氯甲基吡啶 在 盐酸 、 tin 作用下， 以 丙酮 为溶剂， 反应 1.0h， 以70%的产率得到4-(dichloromethyl)pyridine hydrochloride
  参考文献：
  名称：

  Synthesis of tripyridiniumylpropenyl anions from tripyridiniumylcyclopropanes and -cyclopropenes

  摘要：

  The syntheses of three stable, isolatable tripyridiniumylpropenyl anions are described. 1,2,3-Tris(4-(N-methylpyridiniumyl))propenyl anion and 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion were prepared by treating the corresponding cyclopropane with a base. 1,3-Bis(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion was prepared by nucleophilic attack of benzenesulfinate anion on 3-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))cyclopropene. Reduction of this cyclopropene gave either 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methyl)pyridiniumyl))propenyl anion or hexakis(4-(N-methylpyridiniumyl))benzene depending on the solvent used.

  DOI：

  10.1021/jo00032a044

文献信息

• Synthesis of tripyridiniumylpropenyl anions from tripyridiniumylcyclopropanes and -cyclopropenes
  作者：Gerard A. Crispino、Ronald Breslow

  DOI：10.1021/jo00032a044

  日期：1992.3

  The syntheses of three stable, isolatable tripyridiniumylpropenyl anions are described. 1,2,3-Tris(4-(N-methylpyridiniumyl))propenyl anion and 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion were prepared by treating the corresponding cyclopropane with a base. 1,3-Bis(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))propenyl anion was prepared by nucleophilic attack of benzenesulfinate anion on 3-(benzenesulfonyl)-1,2,3-tris(4-(N-methylpyridiniumyl))cyclopropene. Reduction of this cyclopropene gave either 1-(benzenesulfonyl)-1,2,3-tris(4-(N-methyl)pyridiniumyl))propenyl anion or hexakis(4-(N-methylpyridiniumyl))benzene depending on the solvent used.