4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline | 1259439-36-5

分子结构分类

有机化合物 - 有机杂环化合物 - 吡啶及其衍生物

中文名称

——

中文别名

——

英文名称

4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline

英文别名

4-chloro-5,7-difluoro-3-methyl-2-(2-pyridinyl)quinoline；4-chloro-5,7-difluoro-3-methyl-2-pyridin-2-ylquinoline

4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline化学式

CAS

1259439-36-5

化学式

C₁₅H₉ClF₂N₂

mdl

——

分子量

290.7

InChiKey

GYCADYKNHVDHLC-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

386.0±37.0 °C(Predicted)
密度：

1.371±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

4
重原子数：

20
可旋转键数：

1
环数：

3.0
sp3杂化的碳原子比例：

0.07
拓扑面积：

25.8
氢给体数：

0
氢受体数：

4

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
2,4-二氯-5,7-二氟-3-甲基喹啉	2,4-dichloro-5,7-difluoro-3-methylquinoline	1259439-39-8	C₁₀H₅Cl₂F₂N	248.059

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	N-(5-bromo-3-pyridinyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259441-46-7	C₂₀H₁₃BrF₂N₄	427.251
——	N-(3-chloro-5-(4-morpholinyl)phenyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259440-74-8	C₂₅H₂₁ClF₂N₄O	466.918
——	N-(2-chloropyrimidin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1353875-65-6	C₁₉H₁₂ClF₂N₅	383.788
——	5,7-difluoro-3-methyl-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine	1259440-08-8	C₂₄H₂₁F₂N₅O	433.46
——	4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yloxy)pyridin-2-yl)morpholine	1354286-04-6	C₂₄H₂₀F₂N₄O₂	434.445
——	5,7-difluoro-N-(2-fluoro-5-(4-morpholinyl)-3-pyridinyl)-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259440-41-9	C₂₄H₂₀F₃N₅O	451.451
——	N-(6-chloro-5,-methoxy-3,3'-bipyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354289-23-8	C₂₆H₁₈ClF₂N₅O	489.912
——	5,7-difluoro-N-(2-(2-methoxyphenyl)-3-pyridinyl)-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259441-32-1	C₂₇H₂₀F₂N₄O	454.479
——	N-(5-bromo-2-(4-methoxyphenyl)pyridin-3-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1259440-36-2	C₂₇H₁₉BrF₂N₄O	533.375
——	N-(5-bromo-2-(3-methoxyphenyl)pyridin-3-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1259440-40-8	C₂₇H₁₉BrF₂N₄O	533.375
——	5,7-difluoro-3-methyl-N-(2-morpholinopyrimidin-4-yl)-2-(pyridin-2-yl)quinolin-4-amine	1353875-49-6	C₂₃H₂₀F₂N₆O	434.448
——	5,7-difluoro-3-methyl-2-(4-methylpyridin-2-yl)-N-(6-morpholinopyrazin-2-yl)quinolin-4-amine	1353875-50-9	C₂₄H₂₂F₂N₆O	448.475
——	N-(5-bromo-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354290-08-6	C₂₄H₂₀BrF₂N₅O	512.357
——	N-(2,5-bis(2-methoxyphenyl)-3-pyridinyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259441-36-5	C₃₄H₂₆F₂N₄O₂	560.603
——	5-bromo-N-3-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl)-N-2-(3-methoxypropyl)-N-2-methylpyridine-2,3-diamine	1259440-12-4	C₂₅H₂₄BrF₂N₅O	528.399
——	N-(5-bromo-2-(piperidin-1-yl)pyridin-3-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1259440-03-3	C₂₅H₂₂BrF₂N₅	510.384
——	5,7-difluoro-3-methyl-N-(2-morpholino-5-(pyrimidin-5-yl)pyridin-4-yl)-2-(pyridin-2-yl)quinolin-4-amine	1354286-40-0	C₂₈H₂₃F₂N₇O	511.534
——	N-(5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-5'-methoxy-6-(tetrahydro-2H-pyran-4-yl)-3,3'-bipyridin-4-amine	1354287-46-9	C₃₁H₂₇F₂N₅O₂	539.584
——	N-(5-bromo-2-(3,6-dihydro-2H-pyran-4-yl)-3-pyridinyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1259441-41-2	C₂₅H₁₉BrF₂N₄O	509.353
——	N-(5-Bromo-2-cyclohexenylpyridin-3-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1259440-25-9	C₂₆H₂₁BrF₂N₄	507.38
——	5,7-difluoro-N-(6,-methoxy-6-morpholino-3,3,-bipyridin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354285-52-1	C₃₀H₂₆F₂N₆O₂	540.572
——	N-(5-(4-(difluoromethoxy)-3-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354287-52-7	C₃₁H₂₄F₅N₅O₂	593.556
——	5,7-difluoro-N-(5-(3-fluoro-4-methoxyphenyl)-2-morpholinopyridin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354285-79-2	C₃₁H₂₆F₃N₅O₂	557.575
——	N-(5-bromo-2-(2,2-dimethylmorpholino)pyridin-3-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1259440-07-7	C₂₆H₂₄BrF₂N₅O	540.41
——	4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-2-methoxybenzonitrile	1354285-86-1	C₃₂H₂₆F₂N₆O₂	564.594
——	4-((5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)amino)-2-(4-morpholinyl)-5-pyrimidinecarboxylic acid	1353875-43-0	C₂₆H₂₄F₂N₆O₃	506.512
——	tert-butyl 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)piperidine-1-carboxylate	1354287-83-4	C₃₄H₃₈F₂N₆O₃	616.711
——	N-(5-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-(4-morpholinyl)-4-pyridinyl)-5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinamine	1354286-50-2	C₂₉H₂₉F₂N₅O₃S	565.644
——	N-(5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-5'-methoxy-6-(2-oxa-6-azaspiro[3.3]hept-6-yl)-3,3'-bipyridin-4-amine	1354287-42-5	C₃₁H₂₆F₂N₆O₂	552.583
——	N-(5-(2,2-dimethylcyclopentyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354285-92-9	C₃₁H₃₃F₂N₅O	529.633
——	N-(6-(3,6-dihydro-2H-pyran-4-yl)-6'-methoxy-3,3'-bipyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1354285-58-7	C₃₁H₂₅F₂N₅O₂	537.569
——	N-(5-(4-(difluoromethoxy)phenyl)-2-morpholinopyrimidin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1353875-47-4	C₃₀H₂₄F₄N₆O₂	576.553
——	N-(5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-5'-methoxy-6-(3-methoxy-1-azetidinyl)-3,3'-bipyridin-4-amine	1354287-44-7	C₃₀H₂₆F₂N₆O₂	540.572
——	5,7-difluoro-3-methyl-N-(2-morpholino-5-(l,2,3,6-tetrahydropyridin-4-yl)pyridin-4-yl)-2-(pyridin-2-yl)quinolin-4-amine	1354288-64-4	C₂₉H₂₈F₂N₆O	514.578
——	5,7-difluoro-N-(5-(5-methoxypyridin-3-yl)-2-morpholinopyrimidin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine	1353875-46-3	C₂₉H₂₅F₂N₇O₂	541.56
——	N-(3-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-2-morpholinopyrimidin-5-yl)phenyl)methanesulfonamide	1353875-45-2	C₃₀H₂₇F₂N₇O₃S	603.652
——	1-(5,7-difluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-6-(4-morpholinyl)-1,2,2',3',5',6'-hexahydrospiro[indole-3,4'-pyran]	1259512-61-2	C₃₁H₃₀F₂N₄O₂	528.602
——	tert-butyl 4-(4-(5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-6-morpholinopyridin-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate	1354288-62-2	C₃₄H₃₆F₂N₆O₃	614.695

反应信息

作为反应物：

描述：

4-chloro-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinoline 在 tris-(dibenzylideneacetone)dipalladium(0) 、 2-二环己基磷-2,4,6-三异丙基联苯