diethyleneglycol bis(N-vinylcarbamate) | 6420-56-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyleneglycol bis(N-vinylcarbamate)
• 英文别名: 2-[2-(ethenylcarbamoyloxy)ethoxy]ethyl N-ethenylcarbamate
• CAS: 6420-56-0
• 化学式: C₁₀H₁₆N₂O₅
• 分子量: 244.247
• InChiKey: CWMNZGHNHWVDHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  85.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  异氰酸乙烯酯 、 二乙二醇 在 二月桂酸二丁基锡 作用下， 以 二氯甲烷 为溶剂， 反应 26.0h， 以99%的产率得到diethyleneglycol bis(N-vinylcarbamate)
  参考文献：
  名称：

  CROSSLINK AGENTS

  摘要：

  描述了一种新型交联剂，可实现至少一种亲水单体与至少一种通常用于制备眼镜材料的透镜单体的共聚合。这种新型交联剂对亲水单体具有相对较高的选择性，并且与用于聚合透镜单体的交联剂的反应性有限。

  公开号：

  US20110105779A1

文献信息

• Biomedical devices
  申请人：Nunez Ivan M.

  公开号：US20100315588A1

  公开（公告）日：2010-12-16

  Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a hydrophilic polymer comprising one or more hydrophilic units and one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.

  本发明涉及一种生物医学设备，例如由聚合产物形成的隐形眼镜，所述聚合产物包括（a）一种亲水性聚合物，包括一种或多种亲水基团和一种或多种可逆加成断裂链转移（RAFT）剂的硫代羰基硫醚片段；以及（b）一种或多种生物医学设备形成单体。
• Ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US10668676B2

  公开（公告）日：2020-06-02

  An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.

  本发明公开了一种眼科设备，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种主要量的非含硅亲水单体；(b) 交联剂混合物，包括(i)一种或多种含有至少两个乙烯不饱和反应性末端基团的第一交联剂，其中至少两个乙烯不饱和反应性末端基团为含(甲基)丙烯酸酯反应性末端基团；(ii)一种或多种含有至少两个乙烯不饱和反应性末端基团的第二交联剂，其中至少一个乙烯不饱和反应性末端基团为非(甲基)丙烯酸酯反应性末端基团、(c) 一种或多种亲水聚合物或共聚物，包含一种或多种亲水单元和可逆加成片段链转移 （"RAFT"）剂的硫代羰基硫代片段，其中眼科装置的平衡水含量至少为约 45 重量百分 比。
• High water content ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US10816698B2

  公开（公告）日：2020-10-27

  An ophthalmic device is disclosed which is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more first non-silicone-containing hydrophilic monomers; (b) one or more hydrophobic monomers; and (c) a crosslinking agent mixture comprising (i) one or more di-, tri- or tetra(meth)acrylate-containing crosslinking agents and (ii) one or more di-, tri- or tetracarbamate-containing crosslinking agents, wherein the ophthalmic device has an equilibrium water content of at least about 65 weight percent.

  本发明公开了一种眼科装置，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种第一种非硅亲水单体的主要量；(b) 一种或多种疏水单体；和 (c) 交联剂混合物，包括 (i) 一种或多种含二、三或四（甲基）丙烯酸酯的交联剂和 (ii) 一种或多种含二、三或四氨基甲酸酯的交联剂，其中眼科装置的平衡水含量至少为约 65 重量％。
• Method for end-capping a polysiloxane prepolymer
  申请人：Bausch & Lomb Incorporated

  公开号：US10870731B2

  公开（公告）日：2020-12-22

  A method is disclosed which involves the steps of (a) reacting a polysiloxane prepolymer having reactive functional end groups with a non-free radical polymerizable reactive end-capping agent; and (b) reacting the reaction product of step (a) with a free radical polymerizable reactive end-capping agent.

  本发明公开了一种方法，包括以下步骤：(a) 使具有活性官能团端基的聚硅氧烷预聚物与非自由基可聚合活性封端剂反应；(b) 使步骤(a)的反应产物与自由基可聚合活性封端剂反应。
• Water extractable ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US11022722B2

  公开（公告）日：2021-06-01

  A water extractable ophthalmic device is disclosed which is a polymerization product of a monomeric mixture comprising: (a) one or more cyclic lactams; (b) one or more organosilicon-containing block copolymers; (c) one or more bulky siloxane monomers; and (d) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group. The water extractable ophthalmic device has an equilibrium water content of at least about 50 wt. %, a contact angle of less than about 50°, and an oxygen permeability of at least about 60 Barrers.

  本发明公开了一种水萃取眼科装置，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种环内酰胺； (b) 一种或多种含有机硅的嵌段共聚物； (c) 一种或多种大体积硅氧烷单体；(d) 交联剂混合物，包括(i)一种或多种含有至少两个乙烯不饱和反应性末端基团的第一交联剂，其中至少两个乙烯不饱和反应性末端基团为含(甲基)丙烯酸酯反应性末端基团；(ii)一种或多种含有至少两个乙烯不饱和反应性末端基团的第二交联剂，其中至少一个乙烯不饱和反应性末端基团为非(甲基)丙烯酸酯反应性末端基团。水萃取眼科装置的平衡水含量至少约为 50 wt.%，接触角小于约 50°，氧气渗透性至少约为 60 Barrers。