2-烯丙基-1H-苯并咪唑 | 14625-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 2-烯丙基-1H-苯并咪唑
• 英文名称: 2-Allylbenzimidazole
• 英文别名: 2-Allyl-1H-benzo[d]imidazole；2-prop-2-enyl-1H-benzimidazole
• CAS: 14625-03-7
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.203
• InChiKey: NMRACTVLHDREKB-UHFFFAOYSA-N

物化性质

• 沸点：
  350.1±21.0 °C(Predicted)
• 密度：
  1.133±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-烯丙基-1H-苯并咪唑 生成 (e)-(9ci)-2-(1-丙烯基)-1H-苯并咪唑
  参考文献：
  名称：

  Reaction of imidazoles with allyltributyltin in the presence of chloroformate

  摘要：

  The reaction of imidazoles with allyltributyltin in the presence of chloroformate gave 2-allyl-1,3-dialkoxycarbonyl-4-imidazolines in good yields. The addition products were aromatized with potassium ferricyanide under basic condition lo afford corresponding 2-allylimidazoles.

  DOI：

  10.1016/s0040-4039(00)79104-0
• 作为产物：
  描述：

  2-allyl-1,3-bis<(1-chloroethoxy)carbonyl>benzimidazoline 在 氢氧化钾 、 potassium hexacyanoferrate(III) 作用下， 以 四氢呋喃 为溶剂， 反应 120.0h， 以74%的产率得到2-烯丙基-1H-苯并咪唑
  参考文献：
  名称：

  Allylation of azoles with allyltributyltin via unstable N-(alkoxycarbonyl)azolium salts

  摘要：

  The one-pot reactions of imidazoles with allyltributyltin in the presence of alkyl chloroformates gave 2-allyl-1,3-bis(alkoxycarbonyl)-4-imidazolines in good yields. The reactions of thiazoles and oxazoles also proceeded in a similar manner. The instability of the intermediary quaternary salts required the nucleophiles to be added simultaneously with the chloroformate. Therefore, the reaction was specific for allyltributyltin, since it doesn't react with the carbonyl group of chloroformates. The dihydro allyl adducts thus obtained were aromatized with potassium ferricyanide under basic conditions to afford the corresponding 2-allylazoles.

  DOI：

  10.1021/jo00085a020

文献信息

• [EN] PHENYLNAPHTHYLIMIDAZOLES FOR USE ON COPPER SURFACES DURING SOLDERING<br/>[FR] PHÉNYLNAPHTHYLIMIDAZOLES EN VUE D'UNE UTILISATION SUR LES SURFACES EN CUIVRE AU COURS D'UN BRASAGE
  申请人：SHIKOKU CHEM

  公开号：WO2005121101A1

  公开（公告）日：2005-12-22

  A surface treating agent containing a novel phenylnaphthylimidazole compound represented by the following formula is brought into contact with the surface of copper or a copper alloy. In the formula, when A1 is a phenyl group, then A2 represents a 1-naphthyl group or a 2-naphthyl group, and when A1 is a 1-naphthyl group or a 2-naphthyl group, then A2 represents a phenyl group; and R represents a hydrogen atom or a methyl group.

  含有所述下列公式表示的新型苯基萘基咪唑啉化合物的表面处理剂与铜或铜合金的表面接触。在公式中，当A1是苯基时，A2代表1-萘基或2-萘基，当A1是1-萘基或2-萘基时，A2代表苯基；R代表氢原子或甲基。
• 2-Substituted benzimidazole piperidines analogs as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
  申请人：Burnett A. Duane

  公开号：US20050054628A1

  公开（公告）日：2005-03-10

  The present invention discloses compounds of formula I wherein Ar, Y, m, n, R 1 and R 4 are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

  本发明公开了以下式I的化合物 其中Ar、Y、m、n、R1和R4在此有定义，所述化合物是新型黑素浓缩激素（MCH）拮抗剂，以及制备这种化合物的方法。在另一实施例中，本发明公开了包含这种MCH拮抗剂的药物组合物，以及使用它们治疗肥胖、代谢紊乱、食欲紊乱（如过度进食）和糖尿病的方法。
• Composition for Sterilization Comprising W-Alkoxyperoxycarboxylic Acid
  申请人：Kawakami Masayuki

  公开号：US20080009549A1

  公开（公告）日：2008-01-10

  A peroxycarboxylic acid represented by the general formula (I): (wherein R 1 represents a substituted or unsubstituted C1-C10 alkyl group, or a substituted or unsubstituted C6-C10 aryl group, L represents a substituted or unsubstituted C2-C12 divalent linking group, or R 1 and L may combine to form a ring) and a composition comprising said peroxycarboxylic acid are provided. Said peroxycarboxylic acid can sterilize a medical apparatus such as endoscope in a short period of time and has no unpleasant smell.

  通用公式（I）表示的过氧羧酸： （其中R1表示取代或未取代的C1-C10烷基或取代或未取代的C6-C10芳基，L表示取代或未取代的C2-C12双价连接基，或R1和L可以结合形成环）以及包含所述过氧羧酸的组合物。所述过氧羧酸可以在短时间内对医疗器械如内窥镜进行灭菌，并且没有令人不愉快的气味。
• [EN] N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS<br/>[FR] DÉRIVÉS DE N-HYDROXYLSULFONAMIDE UTILISÉS COMME NOUVEAUX DONNEURS DE NITROXYLE PHYSIOLOGIQUEMENT UTILES
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2009042970A1

  公开（公告）日：2009-04-02

  The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.

  该发明涉及公式（I）、（II）或（III）的N-羟基磺酰胺衍生物，其中变量如索权中定义的那样，在生理条件下释放亚硝基（HNO），并且在治疗和/或预防对亚硝基疗法敏感的疾病或病症的发生和/或发展中具有用处，包括心力衰竭和缺血/再灌注损伤。N-羟基磺酰胺衍生物在生理条件下以受控速率释放HNO，HNO释放速率通过改变N-羟基磺酰胺衍生物上的功能基团的性质和位置来调节。
• [EN] NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS<br/>[FR] NOUVEAUX COMPOSES D'AMIDINE DANS LE TRAITEMENT D'INFECTIONS MICROBIENNES
  申请人：UNIV NORTH CAROLINA

  公开号：WO2005033065A1

  公开（公告）日：2005-04-14

  Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections.

  新型胍和二胍化合物在治疗微生物感染方面具有重要作用，包括结核菌、真菌和原虫感染。含有这些化合物的药物配方可用于治疗微生物感染的方法。