2-{[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-pentanoyl-amino}-3-methyl-butyric acid methyl ester | 1198074-66-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-{[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-pentanoyl-amino}-3-methyl-butyric acid methyl ester
• 英文别名: methyl N-{[2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl}-N-pentanoyl-L-valinate；methyl (2S)-2-[[4-[2-(4,4-dimethyl-5H-1,3-oxazol-2-yl)phenyl]phenyl]methyl-pentanoylamino]-3-methylbutanoate
• CAS: 1198074-66-6
• 化学式: C₂₉H₃₈N₂O₄
• 分子量: 478.632
• InChiKey: UHHVIKMJRVBXLF-SANMLTNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  35
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  68.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-{[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-pentanoyl-amino}-3-methyl-butyric acid methyl ester 在 吡啶 、 三氯氧磷 作用下， 以90%的产率得到N-[(2'-氰基联苯-4-基)甲基]-N-(1-氧代戊基)-L-缬氨酸甲酯
  参考文献：
  名称：

  Convenient Synthesis of Valsartan via a Suzuki Reaction

  摘要：

  本文介绍了血管紧张素 II 抑制剂缬沙坦（Diovan）的高效合成方法。芳基芳基键的形成是其合成的关键步骤，该步骤是通过硼酸芳基酯与 2-溴苯基噁唑啉的铃木偶联完成的，具有良好的收率和纯度。这种方法克服了以前报道的合成方法的许多缺点。

  DOI：

  10.3184/030823410x12698758703526
• 作为产物：
  描述：

  2-{[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-amino}-3-methyl-butyric acid methyl ester 、 戊酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以90%的产率得到2-{[2'-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-biphenyl-4-ylmethyl]-pentanoyl-amino}-3-methyl-butyric acid methyl ester
  参考文献：
  名称：

  Improved Synthesis of Valsartan via Nucleophilic Aromatic Substitution on Aryloxazoline

  摘要：

  A highly efficient approach to the synthesis of the angiotensin II receptor antagonist valsartan (Diovan), one of the most important agents used in antihypertensive therapy today is described. The formation of the aryl-aryl bond represents the key step of its synthesis, which has been done by simple nucleophelic aromatic substitution on aryloxazoline with good yield and purity.

  DOI：

  10.1080/00397910902840819

文献信息

• PREPARATION OF GRIGNARD REAGENTS USING A FLUIDIZED BED
  申请人：DPX HOLDINGS B.V.

  公开号：US20160137669A1

  公开（公告）日：2016-05-19

  The present invention relates to a process of preparing a Grignard reagent comprising reacting magnesium particulates in a fluid bed reactor. The present invention further relates to a continuous process comprising fluidizing magnesium particulates in a reactor, forming the Grignard reagent continuously, and reacting the Grignard reagent with a substrate.
• US9550797B2
  申请人：——

  公开号：US9550797B2

  公开（公告）日：2017-01-24
• Convenient Synthesis of Valsartan via a Suzuki Reaction
  作者：Samir Ghosh、A. Sanjeev Kumar、G. N. Mehta

  DOI：10.3184/030823410x12698758703526

  日期：2010.4

  An efficient synthesis of the angiotensin II inhibitor Valsartan (Diovan) is presented. The formation of the aryl–aryl bond represents the key step of its synthesis, which has been done by a Suzuki coupling of aryl boronate with 2-bromophenyl oxazoline with good yield and purity. This method overcomes many of the drawbacks associated with the previously reported syntheses.

  本文介绍了血管紧张素 II 抑制剂缬沙坦（Diovan）的高效合成方法。芳基芳基键的形成是其合成的关键步骤，该步骤是通过硼酸芳基酯与 2-溴苯基噁唑啉的铃木偶联完成的，具有良好的收率和纯度。这种方法克服了以前报道的合成方法的许多缺点。
• Improved Synthesis of Valsartan via Nucleophilic Aromatic Substitution on Aryloxazoline
  作者：Samir Ghosh、A. Sanjeev Kumar、R. Soundararajan、G. N. Mehta

  DOI：10.1080/00397910902840819

  日期：2009.10.12

  A highly efficient approach to the synthesis of the angiotensin II receptor antagonist valsartan (Diovan), one of the most important agents used in antihypertensive therapy today is described. The formation of the aryl-aryl bond represents the key step of its synthesis, which has been done by simple nucleophelic aromatic substitution on aryloxazoline with good yield and purity.