8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxylic acid methyl ester | 67643-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxylic acid methyl ester
• 英文别名: methyl 8-hydroxy-5-oxo-5,6-dihydro-1,6-naphthyridine-7-carboxylate；Methyl-4-hydroxy-1-oxo-2,5-naphthyridin-3-carboxylat；8-hydroxy-5-oxo-5,6-dihydro-[1,6]naphthyridine-7-carboxylic acid methyl ester；8-Hydroxy-5-oxo-5,6-dihydro-[1,6]naphthyridin-7-carbonsaeure-methylester；methyl 8-hydroxy-5-oxo-6H-1,6-naphthyridine-7-carboxylate
• CAS: 67643-24-7
• 化学式: C₁₀H₈N₂O₄
• 分子量: 220.185
• InChiKey: AOTWTCZDLMVIIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  88.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxylic acid methyl ester 在 氢碘酸 、 三氯氧磷 作用下， 生成 1,6-萘啶-8-醇
  参考文献：
  名称：

  972.具有另外的环状氮原子的8-羟基喹啉的类似物。第一部分准备

  摘要：

  DOI：

  10.1039/jr9520004985
• 作为产物：
  描述：

  2,3-吡啶二酰亚胺 在 lithium hydroxide 、 sodium methylate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.5h， 生成 8-hydroxy-1,6-naphthyridin-5(6H)-one-7-carboxylic acid methyl ester
  参考文献：
  名称：

  1,6-和1,7-萘啶。I.喹啉亚氨基乙酸衍生物的重排

  摘要：

  的反应Ñ取代quinolinimides 1A-d与得到的1,6-萘啶2和其通过色谱方法分离1,7-萘啶3的混合物的醇钠。通过将它们的1 H nmr光谱与吡啶甲酸酰胺和烟酰胺的光谱进行比较，确定每对异构体的结构。当将酯1a -c用来自伯醇的醇盐而不是酯的醇盐处理时，发生了全部酯交换反应。实验结果表明，酯交换反应发生在开放的中间物种中。

  DOI：

  10.1002/jhet.5570330226

文献信息

• Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
  申请人：——

  公开号：US20030055071A1

  公开（公告）日：2003-03-20

  Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

  描述了包括某些喹啉羧酰胺和萘啉羧酰胺衍生物在内的氮杂萘基羧酰胺衍生物。这些化合物是HIV整合酶的抑制剂和HIV复制的抑制剂，可用于预防或治疗HIV感染和治疗艾滋病，作为化合物或药学上可接受的盐，或作为药物组合物中的成分，可选择与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。还描述了预防、治疗或延缓艾滋病发作的方法，以及预防或治疗HIV感染的方法。
• [EN] NEUROLOGICALLY-ACTIVE COMPOUNDS<br/>[FR] COMPOSÉS NEUROLOGIQUEMENT ACTIFS
  申请人：PRANA BIOTECHNOLOGY LTD

  公开号：WO2004031161A1

  公开（公告）日：2004-04-15

  The present invention relates to neurologically-active compounds, being heterocyclic compounds having two fused 6-membered rings with a nitrogen atom at position 1 and a hydroxy or mercapto group at position 8 with at least one ring being aromatic. Also disclosed are processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

  本发明涉及具有两个融合的6元环，其中第1位置有一个氮原子，第8位置有一个羟基或巯基基团的神经活性化合物，其中至少一个环是芳香环。还公开了制备这些化合物的方法以及它们作为药物或兽药剂的用途，特别是用于治疗神经系统疾病，更具体地说是神经退行性疾病，如阿尔茨海默病。
• Oil-Spill Identification by Gas Chromatography-Mass Spectrometry
  作者：A. Pavlova、D. Papazova

  DOI：10.1093/chromsci/41.5.271

  日期：2003.5.1

  Two approaches are proposed for the identification of a contaminant caused by the spilling of oil or oil products in water. A capillary gas chromatography (CGC)-mass spectrometry (MS) method for oil spill identification is applied. The presented approaches describe the use of MS data of 18 selective ions of spilled product and the probable pollutant. The spill identification is accomplished on the bases of a quantitative comparison between the ion chromatograms of the samples taken from the probable pollutant and from the spill itself. The other approach is made by chemometric treatment of complete CGC-MS data.

  提出了两种方法用于识别由于石油或石油产品在水中泄漏所引起的污染物。采用毛细管气相色谱-质谱（CGC-MS）方法进行油泄漏识别。所呈现的方法描述了使用泄漏产品和可能污染物的18个选择性离子的质谱数据。泄漏识别基于从可能污染物和泄漏样本中提取的离子色谱图之间的定量比较。另一种方法则是通过化学计量学处理完整的CGC-MS数据。
• Neurologically-active compounds
  申请人：Barnham Jeffrey Kevin

  公开号：US20060167000A1

  公开（公告）日：2006-07-27

  The present invention relates to neurologically-active compounds, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

  本发明涉及神经活性化合物，其制备过程及其作为制药或兽医剂的用途，特别是用于治疗神经病症，更具体地说是神经退行性疾病，如阿尔茨海默病。
• NEUROLOGICALLY ACTIVE COMPOUNDS
  申请人：Barnham Kevin Jeffrey

  公开号：US20100160346A1

  公开（公告）日：2010-06-24

  The present invention relates to neurologically-active compounds, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.

  本发明涉及神经活性化合物，其制备方法以及它们作为制药或兽医制剂的用途，特别是用于治疗神经系统疾病，更具体地说是神经退行性疾病，如阿尔茨海默病。