1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate | 1301633-27-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate
• 英文别名: olmesartan cilexetil；1-cyclohexyloxycarbonyloxyethyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate
• CAS: 1301633-27-1
• 化学式: C₃₃H₄₀N₆O₆
• 分子量: 616.717
• InChiKey: DGSVWHMOQKIGBQ-UHFFFAOYSA-N

物化性质

• 沸点：
  850.1±75.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  154
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N-(三苯基甲基)-5-(4'-溴甲基联苯-2-基)四氮唑 在 盐酸 、 potassium carbonate 、 potassium iodide 、 potassium hydroxide 作用下， 以 N,N-二甲基乙酰胺 、 水 、 异丙醇 、 丙酮 为溶剂， 反应 18.0h， 生成 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylate
  参考文献：
  名称：

  Discovery of olmesartan hexetil: A new potential prodrug of olmesartan

  摘要：

  Synthesis of a new ester prodrug of olmesartan, olmesartan hexetil (1), is described. It is in vitro stabilities and in vivo pharmacokinetics (PK) were evaluated. It showed high stability in simulated gastric juice, and was rapidly hydrolyzed to olmesartan in rat liver microsomes and rat plasma in vitro. C-max and AUC(last) for olmesartan were significantly increased in case of hexetil prodrug, compared with olmesartan medoxomil. Olmesartan hexetil is proposed to be an efficient prodrug of olmesartan with markedly increased oral bioavailability. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.12.090

文献信息

• KR101628758
  申请人：——

  公开号：——

  公开（公告）日：——
• Discovery of olmesartan hexetil: A new potential prodrug of olmesartan
  作者：Mohammed I. El-Gamal、Hanan S. Anbar、Hye Jin Chung、Hyun-Il Kim、Young-Jin Cho、Bong Sang Lee、Sun Ahe Lee、Ji Yun Moon、Dong Jin Lee、Dow Kwon、Won-Jai Choi、Hong-Ryeol Jeon、Chang-Hyun Oh

  DOI：10.1016/j.bmcl.2012.12.090

  日期：2013.3

  Synthesis of a new ester prodrug of olmesartan, olmesartan hexetil (1), is described. It is in vitro stabilities and in vivo pharmacokinetics (PK) were evaluated. It showed high stability in simulated gastric juice, and was rapidly hydrolyzed to olmesartan in rat liver microsomes and rat plasma in vitro. C-max and AUC(last) for olmesartan were significantly increased in case of hexetil prodrug, compared with olmesartan medoxomil. Olmesartan hexetil is proposed to be an efficient prodrug of olmesartan with markedly increased oral bioavailability. (C) 2013 Elsevier Ltd. All rights reserved.