phenoxy propanediol | 1823870-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: phenoxy propanediol
• 英文别名: 1,1-Propanediol, 3-phenoxy-；3-phenoxypropane-1,1-diol
• CAS: 1823870-35-4
• 化学式: C₉H₁₂O₃
• 分子量: 168.192
• InChiKey: VPEKDLBRKOSOMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• TITANIUM-BASED CATALYST FOR VITRIMER RESINS OF EPOXY/ANHYDRIDE TYPE
  申请人：ARKEMA FRANCE

  公开号：US20170044307A1

  公开（公告）日：2017-02-16

  The present invention relates to a composition containing, besides a thermosetting resin of epoxy type and a hardener of anhydride type, at least one catalyst comprising an organometallic titanium complex. This composition enables the manufacture of vitrimer resins, that is to say resins that can be deformed in the thermoset state. It also relates to a kit for manufacturing this composition, an object obtained from this composition and a kit for manufacturing this object. Another subject of the invention relates to an organometallic titanium complex corresponding to the structure titanium bis(3-phenoxy-1,2-propane dioxide) (Ti(PPD) 2 ), and the use thereof as vitrimer effect catalyst in systems based on epoxy resin and on hardener of anhydride type.

  本发明涉及一种组合物，除了包含一种环氧型热固性树脂和一种酸酐型固化剂外，还包含至少一种催化剂，其中该催化剂包括一种有机金属钛络合物。该组合物使得可以制备玻璃转变树脂，即能在热固态下变形的树脂。此外，本发明还涉及一种用于制备该组合物的工具包、从该组合物获得的物体以及用于制造该物体的工具包。本发明的另一个主题涉及一种与结构钛双(3-苯氧基-1,2-丙二醇)（Ti(PPD)2）相对应的有机金属钛络合物，以及其作为基于环氧树脂和酸酐型固化剂体系中玻璃转变效应催化剂的用途。
• COSMETIC, EXTERNAL SKIN PREPARATION, AND MEDICAL INSTRUMENT
  申请人：Iwama Takehisa

  公开号：US20120258059A1

  公开（公告）日：2012-10-11

  It is an object of the present invention to provide a cosmetic or external skin preparation that has an improved feel in use, e.g., excellent stretching on the skin surface, excellent permeation into the skin, and no stickiness, or crinkles. A cosmetic or an external skin preparation, and a medical instrument, comprising at least one lipid peptide-based gelator that contains a low-molecular lipid peptide of Formula (1): (where R 1 to R 3 are independently an organic group) or a pharmaceutically usable salt thereof.

  本发明的目的是提供一种具有改善使用感受的化妆品或外部皮肤制剂，例如，在皮肤表面具有优异的拉伸性，能够良好渗透入皮肤，且没有粘性或皱纹。该化妆品或外部皮肤制剂以及医疗器械包括至少一种脂肽基凝胶剂，该凝胶剂包含式（1）的低分子脂肽基物质（其中R1至R3独立地为有机基团）或其药学可用的盐。
• P-alkyl or cycloalkyl phenoxy alkanols and alkanol esters and use for the treatment of allergic conditions
  申请人：PHARMACO DEVELOPMENT PARTNERS

  公开号：EP0162975A1

  公开（公告）日：1985-12-04

  Compounds of the formula and the pharmaceutically acceptable esters thereof wherein R is alkyl (1-6C) or cycloalkyl (1-6C) optionally fused to the benzene of th ecompound of formula I at positions 3 and 4; and Z is a straight chain alkylene (1-15C) optionally substituted by one or two lower alkyl 11-3C); with the proviso that if the compound of formula I is unesterified, Z cannot be unsubstituted prpylene are disclosed. These compounds, as well as unesterified forms wherein Z is unsubstituted propylene are useful in preventing allergic reactions in humans.

  本发明公开了式 I 的化合物及其药学上可接受的酯类，其中 R 是烷基（1-6C）或环烷基（1-6C），可选择在位置 3 和 4 与式 I 化合物的苯融合；Z 是直链亚烷基（1-15C），可选择被一个或两个低级烷基 11-3C 取代；但如果式 I 化合物是未酯化的，则 Z 不能是未取代的丙烯。 这些化合物以及 Z 是未取代的丙烯的未酯化形式可用于预防人类的过敏反应。
• Substituted phenoxy alkanols for treatment of contact hypersensitivity
  申请人：Berger, Frank M.

  公开号：EP0424553A1

  公开（公告）日：1991-05-02

  Skin diseases are treated by topical application of p-substituted phenoxy alkanols having the structure: in which: R₁ substituted in ortho, meta or para position is selected from hydrogen, halogen, alkyl having from one to six carbon atoms, preferably para-chlorine or para-tertiary-butyl; and bivalent cycloalkylene condensed with the phenyl group at adjacent ring carbons thereof, such as indane; R₂ and R₃ are hydrogen or hydroxyl and at least one of R₂ and R₃ is hydroxyl; and n₁, n₂ and n₃ represent the number of CH₂, CHR₂ and CH₂ groups, respectively, and are numbers within the range from 1 to 10. The topical application to the skin of these compounds jointly with an agent that causes irritation,inflammation or contact sensitization modifies and mitigates such irritation, inflammation and sensitization.

  通过局部使用具有以下结构的对取代苯氧基烷醇来治疗皮肤病： 其中 在正位、偏位或对位被取代的 R₁ 选自氢、卤素、具有 1 至 6 个碳原子的烷基，优选对位氯或对位叔丁基；以及在其相邻环碳上与苯基缩合的二价环亚烷基，如茚； R₂ 和 R₃ 是氢或羟基，且 R₂ 和 R₃ 中至少有一个是羟基；以及 n₁、n₂ 和 n₃ 分别代表 CH₂、CHR₂ 和 CH₂ 基团的数目，并且是 1 至 10 范围内的数字。 将这些化合物与可引起刺激、炎症或接触致敏的制剂一起局部施用到皮肤上，可改 变和减轻这种刺激、炎症和致敏现象。
• PROCESS FOR PRODUCING 1,4-BENZODIOXANE DERIVATIVES
  申请人：DAISO CO., LTD.

  公开号：EP0841334A1

  公开（公告）日：1998-05-13

  A novel process for preparing a 1,4 benzodioxane derivative shown by the formula (1) which is a useful intermediate of circulatory drugs and drugs for psychoneurosis, characterized in sulfonating a phenoxypropanediol with a sulfonyl halide, eliminating the protective group, and then cyclizing the sulfonated compound by treating with a base followed by, if necessary, further sulfonation. In the above formula, R1 is H, RSO2, R is alkyl, phenyl which may be substituted with alkyl, R2, R3, R4 are H, halogen, OH, nitro, cyano, formyl, COOH, alkoxycarbonyloxy, alkyl, alkoxy, haloalkyl, N,N-dialkylamino, alkylcarbonyl, alkoxycarbonyl, phenyl which may be substituted by alkyl, etc.22

  一种制备式（1）所示的 1,4-苯并二噁烷衍生物的新工艺，该衍生物是循环系统药物和精神神经药物的有用中间体，其特征在于用磺酰卤磺化苯氧基丙二醇，消除保护基，然后用碱环化磺化化合物，必要时再进行进一步磺化。 在上式中，R1 是 H、RSO2，R 是烷基、可被烷基取代的苯基，R2、R3、R4 是 H、卤素、OH、硝基、氰基、甲酰基、COOH、烷氧基羰氧基、烷基、烷氧基、卤代烷基、N,N-二烷基氨基、烷基羰基、烷氧基羰基、可被烷基取代的苯基等22。