6-[(1-oxydecyl)amino]hexanoic acid | 69242-01-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-[(1-oxydecyl)amino]hexanoic acid
• 英文别名: 6-decanamidohexanoic acid；6-(Decanoylamino)hexanoic acid
• CAS: 69242-01-9
• 化学式: C₁₆H₃₁NO₃
• mdl: MFCD00427009
• 分子量: 285.427
• InChiKey: YBIBDFKVNLYIKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-[(1-oxydecyl)amino]hexanoic acid 、 (S)-tetrahydroindolizine-1,3,5(2H)-trione 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以56%的产率得到(S)-N-(6-hydroxy-6-(1,3,5-trioxohexahydroindolizin-2(3H)-ylidene)hexyl)decanamide
  参考文献：
  名称：

  抗菌3-酰基四酸和3-酰基哌啶-2,4-二酮的详细研究

  摘要：

  受到抗菌天然产物（例如链霉菌丝蛋白），3-酰基四酸和3-酰基哌啶-2,4-二酮的核心片段的启发，已通过直接与取代的羧酸进行酰化反应从核心杂环合成了一种策略，该策略允许随时使用结构上多样化的化合物库。这些系统的抗菌活性已经针对一系列革兰氏阳性和革兰氏阴性细菌而建立，并且大部分针对前者，在某些情况下非常有效。已获得与针对该文库一小部分的十一碳烯基焦磷酸合酶（UPPS）和/或RNA聚合酶（RNAP）的作用方式一致的数据。活性最高的化合物已显示出在UPPS和RNAP的链霉菌毒素和粘质激肽的已知结合位点上具有结合力。

  DOI：

  10.1002/cmdc.201402093

文献信息

• Process for preparing and/or purifying amido acid phenyl ester sulfonates
  申请人：Procter & Gamble Company

  公开号：US06369250B1

  公开（公告）日：2002-04-09

  The present invention relates to a process for the preparation of a purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. The process comprises the steps of: (a) providing a source of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate; (b) admixing the source with a water-based purification system to form a purification mixture, the water-based purification system having water present at a ratio of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate to water ranging from about 1:0.05 to about 1:50, preferably from about 1:0.1 to about 1:40; (c) separating a purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate from the purification mixture; and (d) collecting said purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino]alkanoate. In preferred embodiments, the purification mixture includes a processin aide such as ethyl alcohol, propyl alcohol, isopropyl alcohol, acetone and mixtures thereof.

  本发明涉及一种制备4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐的纯化过程。该过程包括以下步骤：(a)提供4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐的来源；(b)将该来源与基于水的纯化系统混合，形成纯化混合物，其中基于水的纯化系统中水的比例为4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐与水的比例范围大约为1:0.05至1:50，优选范围为1:0.1至1:40；(c)从纯化混合物中分离出4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐；(d)收集所述的纯化4-磺基苯基-[（1-氧烷酰基）氨基]烷酸盐。在优选实施方式中，纯化混合物包括处理助剂，如乙醇、丙醇、异丙醇、丙酮和它们的混合物。
• Fatty acid derivatives and process of producing them
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04629736A1

  公开（公告）日：1986-12-16

  Fatty acid derivatives represented by the general formula ##STR1## and salts thereof. The compounds of this invention have excellent fibrinolytic action and a highly improved solubility.

  本发明涉及一种以一般式##STR1##表示的脂肪酸衍生物及其盐。该发明的化合物具有出色的纤溶作用和高度改善的溶解度。
• Bleaching compounds and compositions comprising fatty peroxyacids salts
  申请人：Procter & Gamble Company

  公开号：US04634551A1

  公开（公告）日：1987-01-06

  This invention relates to bleaching compounds and compositions that provide effective and efficient surface bleaching of textiles over a wide range of bleach solution temperatures. The bleaching compounds of the invention yield a peroxyacid with a polar amide link in the hydrophobic chain when used in the bleaching composition. In a preferred embodiment, the bleaching compositions of the invention are also detergent compositions.

  本发明涉及漂白化合物和组合物，提供了在广泛的漂白溶液温度下对纺织品进行有效和高效的表面漂白。当在漂白组合物中使用时，本发明的漂白化合物会产生具有极性酰胺链的过氧酸。在一个优选实施例中，本发明的漂白组合物也是洗涤剂组合物。
• Fatty acid derivatives and processes of producing them
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0136879A2

  公开（公告）日：1985-04-10

  Water soluble fibrinolytic fatty acid derivatives of formula (I), and salts thereof in which R' represents an alkanoylamino group the carbon chain of which may be interrupted by at least one oxygen atom, an alkanoyloxy group the carbon chain of which is interrupted by at least one oxygen atom, an alkoxyimino group, or a group shown by the formula R3-(NH-Y-CO)m-Z-(wherein R3 represents an alkanoyl group or a C1-C5 alkylsulfonyl group; Y represents an alkylene group; m represents 1 or 2; and Z represents an oxygen atom or an imino group); R2 represents an alkyl group, an alkylaminocarbonyl group the carbon chain of which may be interrupted by at least one oxygen atom, or an alkoxyaminocarbonyl group the carbon chain of which is interrupted by at least one oxygen atom; represents a single bond or a double bond; a is zero when is a double bond and 1 when is a single bond; b is 0 or 1; c is 0 or 1; n represents an integer of 1 to 3; and A and B are the same or different amino acid residues. Various processes for the production of these compounds are as described.

  式(I)的水溶性纤溶脂肪酸衍生物及其盐类 其中 R'代表碳链可能被至少一个氧原子打断的烷酰氨基、碳链被至少一个氧原子打断的烷酰氧基、烷氧基亚氨基或式 R3-(NH-Y-CO)m-Z-（其中 R3 代表烷酰基或 C1-C5 烷基磺酰基；Y 代表亚烷基；m 代表 1 或 2；Z 代表氧原子或亚氨基）； R2 代表烷基、烷基氨基羰基（其碳链可被至少一个氧原子打断）或烷氧基氨基羰基（其碳链被至少一个氧原子打断）； 代表单键或双键； 当为双键时，a 为 0，当为单键时，a 为 1； b 为 0 或 1； c 为 0 或 1； n 代表 1 至 3 的整数；以及 A 和 B 是相同或不同的氨基酸残基。 生产这些化合物的各种工艺如上所述。
• Bleaching compounds and compositions comprising fatty peroxy acids, salts thereof, and precursors therefor
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0170386B1

  公开（公告）日：1993-12-08