3-(2,2,2-trifluoroethyl)benzaldehyde | 1368345-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2,2,2-trifluoroethyl)benzaldehyde
• CAS: 1368345-17-8
• 化学式: C₉H₇F₃O
• 分子量: 188.149
• InChiKey: OSUXZCYXCQPRGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  198.8±40.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-碘-1,1,1-三氟乙烷 、 3-碘苯甲醛 在 铜 作用下， 以 二甲基亚砜 为溶剂， 反应 55.0h， 以68%的产率得到3-(2,2,2-trifluoroethyl)benzaldehyde
  参考文献：
  名称：

  Copper-Promoted Reductive Coupling of Aryl Iodides with 1,1,1-Trifluoro-2-iodoethane

  摘要：

  An efficient Cu-promoted reductive coupling of aryl iodides with 1,1,1-trifluoro-2-iodoethane has been developed. This reaction could occur in good yields under milder conditions as compared with previous studies. The reaction tolerated nitro, formyl, ester, ether, carbonyl, sulfonyl, and even azo groups.

  DOI：

  10.1021/ol500696p

文献信息

• Using Chlorotrifluoroethane for Trifluoroethylation of (Hetero)aryl Bromides and Chlorides via Nickel Catalysis
  作者：Xuefei Li、Xing Gao、Chun-Yang He、Xingang Zhang

  DOI：10.1021/acs.orglett.1c00058

  日期：2021.2.19

  industrial chemical CF3CH2Cl and (hetero)aryl bromides and chlorides has been reported. The reaction is synthetically simple without the preparation of arylmetals and exhibits high functional group tolerance. The utility of this protocol has been demonstrated by the late-stage modification of pharmaceuticals, providing a facile route for medicinal chemistry.

  已经报道了工业化学CF 3 CH 2 Cl与（杂）芳基溴化物和氯化物之间的镍催化的还原交叉偶联。该反应合成简单，无需制备芳基金属，并且显示出高的官能团耐受性。该方案的效用已通过药物的后期修饰得到证明，为药物化学提供了一条便捷的途径。
• METHOD FOR PROMOTING PLANT GROWTH
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150289512A1

  公开（公告）日：2015-10-15

  The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound represented by the following Formula (1) The compounds indicated by formula (1) are used to promote the growth of plants. A plant seed resulting from treating with the compound represented by formula (1) and comprising an effective quantity of the compound represented by formula (1). A composition for promoting plant growth comprising the compound represented by formula (1) and an inactive ingredient.

  本发明提供了一种促进植物生长的方法，包括使用至少一种由以下式（1）表示的化合物处理植物。由式（1）表示的化合物被用于促进植物生长。经由使用由式（1）表示的化合物处理而得到的植物种子，含有由式（1）表示的化合物的有效量。促进植物生长的组合物包括由式（1）表示的化合物和一种无活性成分。
• Exploiting the trifluoroethyl group as a precatalyst ligand in nickel-catalyzed Suzuki-type alkylations
  作者：Yi Yang、Qinghai Zhou、Junjie Cai、Teng Xue、Yingle Liu、Yan Jiang、Yumei Su、Lungwa Chung、David A. Vicic

  DOI：10.1039/c9sc00554d

  日期：——

  A bis-trifluoroethyl coordinated nickel/bipyridine complex has been developed as efficient precatalyst for diverse Suzuki-type alkylations which features unconventional precatalyst initiation mode.

  已开发出一种双三氟乙基配位的镍/双吡啶配合物，作为高效的预催化剂，用于多样化的铃木型烷基化反应，具有非传统的预催化剂启动模式。
• Novel asymmetric monofluorinated benzaldehyde alditol derivatives and compositions and articles containing same
  申请人：——

  公开号：US20020193473A1

  公开（公告）日：2002-12-19

  Plastic additives which are useful as nucleating agents and which are especially useful for improving the optical properties of polymeric materials are provided. More particularly, this invention relates to certain asymmetric DBS compounds comprising monofluoro- or mono(trifluoroalkyl)-pendant groups on one ring of the aforementioned DBS and the other ring system cannot be monofluorinated. Such compounds may be added to or incorporated within polymer compositions which may then be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive asymmetric benzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.

  本发明提供了可用作成核剂的塑料添加剂，它们特别适用于改善聚合物材料的光学特性。更具体地说，本发明涉及某些不对称 DBS 化合物，这些化合物在上述 DBS 的一个环上含有单氟或单（三氟烷基）附属基团，而另一个环系统不能单氟化。此类化合物可添加到聚合物组合物中或与聚合物组合物结合，然后可用于食品或化妆品容器和包装（仅举例说明）。这些本发明的不对称亚苄基山梨醇乙缩醛还可用作水和有机溶剂的胶凝剂，特别是用于制备止汗凝胶棒的胶凝剂。
• US6512030B2
  申请人：——

  公开号：US6512030B2

  公开（公告）日：2003-01-28