2-甲基-1,4-二氧杂环癸烷-5,10-二酮 | 93777-90-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-甲基-1,4-二氧杂环癸烷-5,10-二酮
• 英文名称: 2-Methyl-1,4-dioxecane-5,10-dione
• CAS: 93777-90-3
• 化学式: C₉H₁₄O₄
• 分子量: 186.2
• InChiKey: VGHCVSPDKSEROA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] DIMERIZATION STRATEGIES AND COMPOUNDS FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY<br/>[FR] STRATÉGIES DE DIMÉRISATION ET COMPOSÉS POUR L'IMAGERIE MOLÉCULAIRE ET/OU LA RADIO-IMMUNOTHÉRAPIE
  申请人：UNIV OF PITTSBURGH -OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：WO2017192605A1

  公开（公告）日：2017-11-09

  The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.

  本发明提供了一种用于靶向分子成像和/或靶向药物传递的多价化合物，其中两个组分或靶向分子分别与细胞上的一个或多个生物标志物相互作用。本发明还提供了一种多功能螯合剂来结合这些靶向分子。本发明还提供了一种体外高通量筛选测定法来确定间隔分子的长度。本发明还涉及用于靶向分子成像和/或靶向药物传递的化合物/探针、试剂盒和方法。
• Polyester compositions and processes for moulding them
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0015146A1

  公开（公告）日：1980-09-03

  Compositions comprising (i) thermoplastic polyester of aliphatic diol and dicarboxylic acid, at least 95 mole percent of said acid being terephthalic acid, (ii) inert particulate nucleating agent (iii) plasticizer and/or oligomeric polyester and (iv) segmented polyester-polyether block copolymer are disclosed as useful moulding compounds. The preferred polyesters include poly (ethylene terephthalate) and the crystallization rate of the polyester component is promoted by components (iii) and or (iv) sothatthe compositions can be moulded to form crystalline products at low temperatures. Moulding processes of the invention are carried out at less than 100°C mould temperature.

  作为有用的模塑化合物，公开了由以下成分组成的组合物：(i) 脂肪族二元醇和二羧酸的热塑性聚酯，其中至少 95 摩尔%的酸为对苯二甲酸；(ii) 惰性微粒成核剂；(iii) 增塑剂和/或低聚酯；(iv) 段聚酯-聚醚嵌段共聚物。优选的聚酯包括聚对苯二甲酸乙二醇酯，成分(iii)和或(iv)可促进聚酯成分的结晶速率，从而使组合物在低温下也能模塑形成结晶产品。本发明的模塑工艺可在低于 100°C 的模具温度下进行。
• Diamine/diol chain extender blends for RIM process
  申请人：GAF CORPORATION

  公开号：EP0102203A1

  公开（公告）日：1984-03-07

  A chain extending agent for reaction injection molding (RIM) comprising a normally liquid blend of butanediol and a toluene diamine mono-substituted with an electron withdrawing group and having the formula wherein X is vicinal to an amino radical and is selected from the group of halogen, CN, N02, acyl, carboxylate and isomeric mixtures thereof, and wherein the butanediol and diamine are combined in a critical mole ratio of from 4:1 to about 19:1. The above blend is particularly useful in the preparation of large moldings of polyurethane-polyurea elastomer by the RIM or RRIM (reinforced reaction injection molding) process wherein instant preformed blend is added to a mixture of polyol reactant and catalyst before polymerization in the mold with isocyanate to produce a urethane/ urea polymer product of improved properties. Accordingly, the invention also concerns an enhanced RIM or RRIM process and improved product by the use of a mixture of the present chain extender blend and polyol reactant maintain- able in the liquid state at ambient temperature.

  一种用于反应注塑成型（RIM）的延链剂，由丁二醇和单取代了一个取电子基团的甲苯二胺的常液态混合物组成，其式为 其中 X 与氨基邻接，选自卤素、CN、N02、酰基、羧基及其异构混合物，丁二醇和二胺的临界摩尔比为 4:1 至约 19:1。上述混合物特别适用于通过 RIM 或 RRIM（增强反应注塑成型）工艺制备聚氨酯-聚脲弹性体的大型模塑件，其中在模具中与异氰酸酯聚合之前，将即时预制的混合物添加到多元醇反应剂和催化剂的混合物中，以生产性能更好的聚氨酯/脲聚合物产品。因此，本发明还涉及一种增强型 RIM 或 RRIM 工艺，以及通过使用本扩链剂混合物和多元醇反应剂在环境温度下保持液态的混合物而改进的产品。
• P-TMXDI polyurethane elastomers with good compression set properties
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0171536A1

  公开（公告）日：1986-02-19

  Polyurethane elastomer compositions, having a compression set less than or equal to about 40% are disclosed. These polyurethane elastomer compositions comprise the reaction product of: (a) A polyurethane prepolymer having terminally reactive isocyanate groups and formed as a reaction product of polymeric diol with a stoichiometric excess of p-tetramethylxylene diisocyanate (p-TMXDI); with (b) A curatively effective amount of a curative selected from the group consisting of: diethyltoluenediamine (DETDA), 2,4,-bis(p-aminobenzyl)-aniline (BABA), and mixtures thereof; and (c) Optionally, from about 0.01% to about 2% by weight of catalyst, based on the weight of curative. These polyurethane elastomers are used in molded articles which are to be used under load as in machine rolls and wheels.

  本发明公开了压缩永久变形小于或等于约 40% 的聚氨酯弹性体组合物。这些聚氨酯弹性体组合物由以下物质的反应产物组成： (a) 具有末端反应性异氰酸酯基团的聚氨酯预聚物，该预聚物是聚合二元醇与对四甲基二异氰酸酯（p-TMXDI）按一定比例过量的反应产物；以及 (b) 选自以下组别的有效固化剂：二乙基甲苯二胺 (DETDA)、2,4,-双(对氨基苄基)苯胺 (BABA) 及其混合物；以及 (c) 可选地，以固化剂重量计，催化剂的重量占约 0.01%至约 2%。 这些聚氨酯弹性体可用于机器辊子和轮子等承重模制件。
• Polymeric modifier compositions
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0411822A2

  公开（公告）日：1991-02-06

  Modifier compositions of acrylic core/shell polymers and alkyl methacrylate-butadiene-styrene core/shell polymers are added to polyvinyl halides to provide materials with improved color depth and impact strength, as well as reduced pearlescence.

  将丙烯酸芯/壳聚合物和甲基丙烯酸烷基酯-丁二烯-苯乙烯芯/壳聚合物的改性剂组合物添加到聚乙烯卤化物中，可使材料具有更好的色深和抗冲击强度，并减少珠光。