5-ethyl-2-(4-methoxyphenyl)-1,3,4-oxadiazole | 944700-59-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-ethyl-2-(4-methoxyphenyl)-1,3,4-oxadiazole
• 英文别名: 2-Ethyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole
• CAS: 944700-59-8
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: FDVNZAPZNAXWEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲氧基苯甲酰肼 、 原丙酸三乙酯 在 Nafion(R)NR₅₀ 作用下， 反应 0.17h， 以90%的产率得到5-ethyl-2-(4-methoxyphenyl)-1,3,4-oxadiazole
  参考文献：
  名称：

  更绿色，更快速地获得生物活性杂环：一锅法无溶剂合成1,3,4-恶二唑和1,3,4-噻二唑

  摘要：

  报道了在微波辐射下通过酰肼与原烷基三乙基酯的缩合反应得到的一种新颖的无锅无溶剂合成1,3,4-恶二唑和1,3,4-噻二唑的方法。此绿色协议是有效地由固体负载的Nafion催化® NR50和五硫化二磷在氧化铝（P 4小号10 /的Al 2 ö 3具有优良的产率）。

  DOI：

  10.1016/j.tetlet.2007.11.165

文献信息

• Benzothiophene derivatives
  申请人：Hubbs Jed Lee

  公开号：US20090082308A1

  公开（公告）日：2009-03-26

  The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

  本发明涉及一类新型的苯并噻吩酰胺衍生物。这些羟肟酸化合物可用于治疗癌症。苯并噻吩酰胺化合物还可以抑制组蛋白去乙酰化酶，并适用于选择性诱导终末分化，阻止肿瘤细胞的生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有肿瘤细胞增殖特征的患者。该发明的化合物也可用于预防和治疗TRX介导的疾病，如自身免疫性、过敏性和炎症性疾病，以及中枢神经系统（CNS）疾病的预防和/或治疗，如神经退行性疾病。本发明还提供了包含羟肟酸衍生物的药物组合物和这些药物组合物的安全剂量方案，易于遵循，并在体内产生治疗有效量的羟肟酸衍生物。
• Quinazolinone Compounds and Derivatives Thereof
  申请人：AMGEN INC.

  公开号：US20150225396A1

  公开（公告）日：2015-08-13

  Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的化合物是坦克酰酶的有用抑制剂。公式I的化合物具有以下结构：其中变量的定义在此提供。
• Efficient synthesis of 1,3,4-oxadiazoles promoted by NH4Cl
  作者：Krishna Kumar Gnanasekaran、Baskar Nammalwar、Maeghan Murie、Richard A. Bunce

  DOI：10.1016/j.tetlet.2014.10.028

  日期：2014.12

  An efficient and inexpensive approach to the synthesis of 2-substituted and 2,5-disubstituted 1,3,4-oxadiazoles from arylhydrazides and orthoesters is reported using catalytic NH4Cl. The conditions are mild, and thus, compatible with a variety of functional groups. The optimized reaction is performed using 30 mol % of NH4Cl in 100% EtOH and is generally complete within I h for non-aromatic orthoesters and 2-10 h for aromatic orthoesters. The reaction permits both electron-releasing and electron-withdrawing groups on the arylhydrazide substrate. Most products are formed in high yields and require only minimal purification. Compared with earlier reports, the current reactions proceed in shorter time and require less of the orthoester. (C) 2014 Elsevier Ltd. All rights reserved.
• US7834034B2
  申请人：——

  公开号：US7834034B2

  公开（公告）日：2010-11-16
• US9505749B2
  申请人：——

  公开号：US9505749B2

  公开（公告）日：2016-11-29