2-甲基-2-(苯基巯基)丙醛 | 63996-66-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-甲基-2-(苯基巯基)丙醛
• 英文名称: 2-methyl-2-(phenylthio)propanal
• 英文别名: 2-methyl-2-phenylsulfanylpropionaldehyde；2-(Phenylsulfanyl)-2-methylpropanal；2-methyl-2-(phenylsulfenyl)propanal；2-phenylsulfanyl-2-methyl propanal；methyl-2-phenylsulfanylpropional；2-methyl-2-phenylthiopropanal；2-Methyl-2-(Phenylsulfanyl)Propanal；2-methyl-2-phenylsulfanylpropanal
• CAS: 63996-66-7
• 化学式: C₁₀H₁₂OS
• mdl: MFCD00243420
• 分子量: 180.271
• InChiKey: SZJAXFYFRGJCCV-UHFFFAOYSA-N

物化性质

• 沸点：
  112-116°C 4mm

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2-甲基-2-(苯基巯基)丙醛 在 triethyloxonium fluoroborate 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到2,3-二甲基苯并噻吩
  参考文献：
  名称：

  Groot, Aede de; Jansen, Ben J. M., Synthesis, 1985, # 4, p. 434 - 436

  摘要：

  DOI：
• 作为产物：
  描述：

  2-methyl-2-phenylthiopropanal tosylhydrazone 在 三氟化硼乙醚 作用下， 以 水 、 丙酮 为溶剂， 反应 96.0h， 以93%的产率得到2-甲基-2-(苯基巯基)丙醛
  参考文献：
  名称：

  Reese, Colin B.; Sanders, H. Paul, Journal of the Chemical Society. Perkin transactions I, 1982, # 11, p. 2719 - 2724

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF AKT ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITE DE LA PROTEINE KINASE B (AKT)
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005085227A1

  公开（公告）日：2005-09-15

  Invented are novel pyridine compounds, the use of such compounds as inhibitors of PKB/AKT kinase activity and in the treatment of cancer and arthritis.

  发明了新型的吡啶化合物，以及这些化合物作为PKB/AKT激酶活性的抑制剂以及用于治疗癌症和关节炎的用途。
• Additive Pummerer reactions of vinylic sulfoxides. Synthesis of γ-hydroxy-α,β-unsaturated esters, α-hydroxyketones, and 2-phenylsulfenyl aldehydes and primary alcohols
  作者：Donald Craig、Kevin Daniels、A.Roderick MacKenzie

  DOI：10.1016/s0040-4020(01)81812-3

  日期：1993.1

  the E-isomers. β-Monosubstituted vinylic sulfoxides 1 possessing a β-aryl group, and β-disubstituted vinylic sulfoxides 3 reacted with trifluoromethanesulfonic anhydride-sodium acetate in acetic anhydride to give 2-(phenylsulfenyl)acylals 14. These gave 2-phenylsulfenyl aldehydes 15 upon basic methanolysis, and the corresponding primary alcohols 16 on reduction with sodium borohydride. Reaction of both

  在二氯甲烷中用三氟乙酸酐处理β-单取代的乙烯基亚砜1可获得1,2-双（三氟乙酰氧基）硫醚6的优异收率。2-烷基取代的6的轻度碱性甲醇分解得到α-羟醛11，为单体-二聚体混合物。2-芳基类似物的类似处理提供了芳基（羟甲基）酮12。化合物11与甲氧基羰基亚甲基三苯基膦进行Wittig反应，得到高产率的γ-羟基-α，β-不饱和酯13，主要为E-异构体。β-单取代乙烯基亚砜1具有β-芳基的基团，和β-二取代的乙烯基亚砜3与三氟甲磺酸酐-乙酸钠在乙酸酐中反应，得到2-（苯基亚磺酰基）酰基14。它们在碱性甲醇分解时得到2-苯基亚硫基醛15，而在用硼氢化钠还原时得到相应的伯醇16。对映体纯的乙烯基亚砜1o的两种几何异构体与TFAA的反应得到外消旋体6o，为非对映异构体的混合物。光学纯（的反应ë） -和（Ž） - 1P与乙酸酐三氟乙酸酐钠，得到acylalee分别为10.5和19％中的19。
• [EN] ORGANOCATALYSTS AND METHODS OF USE IN CHEMICAL SYNTHESIS<br/>[FR] ORGANOCATALYSEURS ET PROCEDES D'UTILISATION DE CES DERNIERS DANS LA SYNTHESE CHIMIQUE
  申请人：STC UNM

  公开号：WO2006007586A1

  公开（公告）日：2006-01-19

  The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-­selective reactions, and the method of their synthesis and use. These compounds have the structure of the Formulas (I) and (II). Where X is independently selected from CH2, N-Ra, O, S or C=O; Y is CH2, N-Ra, O, S or C=O, with the proviso that at least one of X or Y is CH2, and preferably both of X and Y are CH2; Ra is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 alkyl including a C3-C6 cyclic alkyl group, or an optionally substituted aryl group, preferably an optionally substituted phenyl group; Rb is H, an optionally substituted C1-C12 alkyl, preferably an optionally substituted C1-C6 acyclic or a a C3-C6 cyclic alkyl group, CHO, N(Me)O, CO(S)Ra or the group of Formula (III). Where Rc and Rd are each independently H, F, C1, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C12 alkyl, more preferably a C1-C6 alkyl, and an optionally substituted aryl group, or together Rc and Rd form an optionally substituted carbocyclic or optionally substituted heterocyclic ring; R1 is OH, OR, NR'R', NHC(=O)R, NHSO2R; R2 is H, F, C1, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1­C6 alkyl, an optionally substituted aryl group or a =O group (which establishes a carbonyl group with the carbon to which =O is attached; R3 is H, OH, F, C1, Br, I, Cl, an optionally substituted C1-C20 alkyl, alkenyl or alkynyl ('hydrocarbyl') group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl, such that the carbon to which R3 is attached has an R or S configuration; R is H, an optionally substituted C1-C20 alkyl, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group, R' and R' are each independently H, an optionally substituted C1-C20 alkyl group, preferably an optionally substituted C1-C6 alkyl, or an optionally substituted aryl group; or together R' and R' form an optionally substituted heterocyclic, preferably a 4 to 7 membered optionally substituted heterocyclic group or an optionally substituted heteroaryl ring with the nitrogen to which R' and R' are attached; and wherein said compound is free from a metal catalyst.

  本发明涉及一般包括有机催化剂的组合物，该催化剂促进立体选择性反应以及其合成和使用方法。特别地，本发明涉及无金属有机催化剂以促进立体选择性反应，以及其合成和使用方法。这些化合物具有以下结构的式（I）和（II）。其中X独立地选择自CH2、N-Ra、O、S或C=O；Y为CH2、N-Ra、O、S或C=O，但至少X或Y中的一个为CH2，最好是X和Y都为CH2；Ra为H、可选择地取代的C1-C12烷基，最好是可选择地取代的C1-C6烷基，包括C3-C6环烷基，或可选择地取代的芳基，最好是可选择地取代的苯基；Rb为H、可选择地取代的C1-C12烷基，最好是可选择地取代的C1-C6无环或C3-C6环烷基，CHO、N(Me)O、CO(S)Ra或式（III）的基团。其中Rc和Rd各自独立地为H、F、C1、可选择地取代的C1-C20烷基，最好是可选择地取代的C1-C12烷基，更好地是C1-C6烷基，以及可选择地取代的芳基，或者Rc和Rd一起形成可选择地取代的碳环或可选择地取代的杂环；R1为OH、OR、NR'R'、NHC(=O)R、NHSO2R；R2为H、F、C1、可选择地取代的C1-C20烷基，最好是可选择地取代的C1-C6烷基，可选择地取代的芳基或=O基团（与=O连接的碳形成羰基基团）；R3为H、OH、F、C1、Br、I、Cl、可选择地取代的C1-C20烷基、烯基或炔基（'烃基'），最好是可选择地取代的C1-C6烷基，或可选择地取代的芳基，使得R3连接的碳具有R或S构型；R为H、可选择地取代的C1-C20烷基，最好是可选择地取代的C1-C6烷基，或可选择地取代的芳基，R'和R'各自独立地为H、可选择地取代的C1-C20烷基，最好是可选择地取代的C1-C6烷基，或可选择地取代的芳基；或者R'和R'一起形成可选择地取代的杂环，最好是4到7成员的可选择地取代的杂环基团或与R'和R'连接的氮原子形成可选择地取代的杂芳基环；其中所述化合物不含金属催化剂。
• Pyridine derivatives
  申请人：Imperial Chemical Industries PLC

  公开号：US05053415A1

  公开（公告）日：1991-10-01

  The invention concerns novel, pharmaceutically useful 1,3-dioxane alkenoic acid derivatives of the formula I containing a pyridyl moiety at position 4 of the dioxane ring and in which the groups at positions 2, 4 and 5 have cis-relative stereochemistry, X is hydrogen, alkoxy or hydroxy, Y is vinylene, n is 1 or 2, A.sup.1 is alkylene, the substituents R.sup.1 and R.sup.2 at position 2 of the dioxane ring have a variety of values defined hereinafter, and R.sup.4 is hydroxy, a physiologically acceptable alcohol residue or alkanesulphonamido, and the pharmaceutically acceptable salts thereof. The invention also includes processes for the manufacture and use of the acid derivatives as well as pharmaceutical compositions for therapeutic use in one or more of a variety of diseases such as ischaemic heart disease, cerebrovascular disease, asthmatic disease and/or inflammatory disease.

  本发明涉及一类新型的、具有药物活性的1,3-二氧杂环戊烷烯酸衍生物，其通式为I，其中二氧杂环戊烷环的第4位含有吡啶基团，且第2、4和5位的基团具有顺式相对立体化学结构，X是氢、烷氧基或羟基，Y是乙烯基，n是1或2，A.sup.1是亚烷基，二氧杂环戊烷环第2位的取代基R.sup.1和R.sup.2具有多种后续定义的值，而R.sup.4是羟基、生理上可接受的醇残基或烷磺酰胺基，以及它们的药物可接受盐。本发明还包括制造和使用这些酸衍生物的方法，以及用于治疗多种疾病如缺血性心脏病、脑血管病、哮喘病和/或炎症性疾病的药物组合物。
• The scope and limitation of the [1,4]-SPh shift in the synthesis of allylic alcohols†
  作者：Varinder K. Aggarwal、Jason Eames、Maria A. de las Heras、Sara McIntyre、Stuart Warren

  DOI：10.1039/b005349j

  日期：——

  Treatment of a series of 4-phenylsulfanyl-1,3-diols with toluene-p-sulfonyl chloride in pyridine gives stereospecifically substituted allylic alcohols in near quantitative yield via a [1,4]-SPh shift. We comment on the structural variation at both the migration origin and terminus on the outcome of the title reaction and define its limits.

  用以下方法处理一系列4-苯基硫基-1,3-二醇 甲苯-对磺酰氯 在 吡啶 给出立体定向取代的烯丙基 酒类通过[1,4] -SPh位移获得接近定量的产量。我们对迁移起点和终点反应的结局处的结构变异进行评论，并定义其极限。