ethyl (coumarin-3-yl)carbamate | 1442690-84-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: ethyl (coumarin-3-yl)carbamate
• 英文别名: ethyl N-(2-oxochromen-3-yl)carbamate
• CAS: 1442690-84-7
• 化学式: C₁₂H₁₁NO₄
• 分子量: 233.224
• InChiKey: RCMHTLFCBZRNAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-氨基香豆素 、 氯甲酸乙酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以74%的产率得到ethyl (coumarin-3-yl)carbamate
  参考文献：
  名称：

  Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

  摘要：

  A series of (coumarin-3-yl)carbamates was synthesized and evaluated in vitro as monoamine oxidase (MAO-A and MAO-B) inhibitors. Most of the new compounds selectively inhibited MAO-B isoenzyme with IC50 values in the micro or nanoMolar ranges. Since these compounds must achieve the brain cells, theoretical evaluation of ADME properties were also carried out. Compound 8 (benzyl(coumarin-3yl)carbamate), which presented the most interesting in vitro MAO-B inhibitory profile (IC50 against MAO-B = 45 nM), was subjected to further studies. This in vitro MAO-B inhibitory activity is comparable with that of the selegiline, the reference compound (IC50 against MAO-B = 20 nM). Taking into account the in vitro results of compound 8, in vivo assays and docking calculations were also carried out for this derivative. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.02.009

文献信息

• OPTICAL SENSOR
  申请人：The City University

  公开号：EP2666010A1

  公开（公告）日：2013-11-27
• [EN] OPTICAL SENSOR<br/>[FR] CAPTEUR OPTIQUE
  申请人：UNIV CITY

  公开号：WO2012098242A1

  公开（公告）日：2012-07-26

  An optical sensor (1) for pH monitoring in highly alkaline mediums, the sensor (1) comprising: a sensor body (3) that fluoresces when illuminated by light, the sensor body (3) being configured to exhibit a change in fluorescence in response to changing pH in highly alkaline mediums, the sensor further comprising means (5) for coupling the sensor body to a source of illumination. A system (11) is also disclosed, along with methods of synthesising pH sensitive polymerisable fluorescent coumarin dyes, and pH sensitive polymerisable fluorescent coumarin dyes.
• Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study
  作者：Maria J. Matos、Santiago Vilar、Rosa Mª Gonzalez-Franco、Eugenio Uriarte、Lourdes Santana、Carol Friedman、Nicholas P. Tatonetti、Dolores Viña、Jose A. Fontenla

  DOI：10.1016/j.ejmech.2013.02.009

  日期：2013.5

  A series of (coumarin-3-yl)carbamates was synthesized and evaluated in vitro as monoamine oxidase (MAO-A and MAO-B) inhibitors. Most of the new compounds selectively inhibited MAO-B isoenzyme with IC50 values in the micro or nanoMolar ranges. Since these compounds must achieve the brain cells, theoretical evaluation of ADME properties were also carried out. Compound 8 (benzyl(coumarin-3yl)carbamate), which presented the most interesting in vitro MAO-B inhibitory profile (IC50 against MAO-B = 45 nM), was subjected to further studies. This in vitro MAO-B inhibitory activity is comparable with that of the selegiline, the reference compound (IC50 against MAO-B = 20 nM). Taking into account the in vitro results of compound 8, in vivo assays and docking calculations were also carried out for this derivative. (C) 2013 Elsevier Masson SAS. All rights reserved.