oxo-4 butene-2 oate de benzhydryle | 88726-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: oxo-4 butene-2 oate de benzhydryle
• 英文别名: 4-oxobuten-(2)-oic acid benzhydryl ester；benzhydryl (E)-4-oxobut-2-enoate
• CAS: 88726-02-7
• 化学式: C₁₇H₁₄O₃
• 分子量: 266.296
• InChiKey: GUJOIVDJJMRRCO-KPKJPENVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  oxo-4 butene-2 oate de benzhydryle 在 偶氮二异丁腈 、 三正丁基氢锡 、 三乙胺 作用下， 以 甲苯 为溶剂， 生成 [(2R,3S,4S,5R,6S)-6-Methoxy-7-oxo-3-propylsulfanyl-2-((4S,5R,4'R)-2,2,2',2'-tetramethyl-[4,4']bi[[1,3]dioxolanyl]-5-yl)-1-aza-bicyclo[3.2.0]hept-4-yl]-acetic acid benzhydryl ester
  参考文献：
  名称：

  The use of radical decarboxylation in the preparation of 1-methylcarbapenem antibiotic precursors from D-glucosamine

  摘要：

  The stereocontrolled synthesis of optically active 1-methylcarbapenams has been performed by radical cyclization and radical decarboxylation. 1,3,4-Trisubstituted-2-azetidinones, prepared by the Staudinger reaction with D-glucosamine as chiral auxiliary and sorbic acid were used as starting materials.

  DOI：

  10.1016/s0957-4166(00)86289-8
• 作为产物：
  描述：

  (1Z)-1-benzhydryloxybuta-1,3-dien-1-olate;chloropalladium(1+) 以50%的产率得到
  参考文献：
  名称：

  MUZART, J.;PALE, P.;PETE, J. P., TETRAHEDRON LETT., 1983, 24, N 42, 4567-4568

  摘要：

  DOI：

文献信息

• 3-Beta-(3,4-disubstituted succinimido)azetidinones
  申请人：ELI LILLY AND COMPANY

  公开号：EP0252744A2

  公开（公告）日：1988-01-13

  3β-(3,4-Disubstituted succinimido)azetidinones are provided via stereoselective cycloaddition of imines with chiral auxiliary 3,4-disubstituted succinimidoacetyl chlorides. The chiral auxiliary e.g., 3S,4S-dibenzoyloxy-and 3S,4S-diacetoxysuccinimidoacetyl chloride, is obtained from tartaric acid via anhydride and imide formation with retention of chirality. The chiral azetidinones obtained are useful intermediates to β-lactam antibacterial compounds.

  3β-(3,4-二取代琥珀酰亚胺基)氮杂环丁酮是通过亚胺与手性辅助剂 3,4-二取代琥珀酰亚胺基乙酰氯的立体选择性环加成反应而获得的。 手性辅助剂，如 3S,4S-二苯甲酰氧基和 3S,4S-二乙酰氧基琥珀酰亚胺基乙酰氯，是从酒石酸中通过酸酐和亚胺的形成而获得的，并保留了手性。 所获得的手性氮杂环丁酮是β-内酰胺类抗菌化合物的有用中间体。
• Muzart, J.; Pale, P.; Pete, J.P., Bulletin de la Societe Chimique de France, 1988, # 4, p. 731 - 739
  作者：Muzart, J.、Pale, P.、Pete, J.P.、Riahi, A.

  DOI：——

  日期：——
• US4734498A
  申请人：——

  公开号：US4734498A

  公开（公告）日：1988-03-29
• The use of radical decarboxylation in the preparation of 1-methylcarbapenem antibiotic precursors from D-glucosamine
  作者：Josefa Anaya、Derek H.R. Barton、Ma Cruz Caballero、Stephan D. Gero、Manuel Grande、Nieves M. Laso、José I.M. Hernando

  DOI：10.1016/s0957-4166(00)86289-8

  日期：1994.11

  The stereocontrolled synthesis of optically active 1-methylcarbapenams has been performed by radical cyclization and radical decarboxylation. 1,3,4-Trisubstituted-2-azetidinones, prepared by the Staudinger reaction with D-glucosamine as chiral auxiliary and sorbic acid were used as starting materials.
• MUZART, J.;PALE, P.;PETE, J. P., TETRAHEDRON LETT., 1983, 24, N 42, 4567-4568
  作者：MUZART, J.、PALE, P.、PETE, J. P.

  DOI：——

  日期：——