4-amino-2-(methylthio)pyrimidine-5-carbothioamide | 55441-41-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-amino-2-(methylthio)pyrimidine-5-carbothioamide
• 英文别名: 4-Amino-2-methylthio-5-pyrimidinecarbothioamide；4-amino-2-methylsulfanylpyrimidine-5-carbothioamide
• CAS: 55441-41-3
• 化学式: C₆H₈N₄S₂
• 分子量: 200.288
• InChiKey: SJEFQEJOCABUJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  135
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-amino-2-(methylthio)pyrimidine-5-carbothioamide 、 3-乙酰氨基-2-溴苯乙酮 以 乙腈 为溶剂， 反应 12.0h， 以74%的产率得到N-(3-(2-(4-amino-2-(methylthio)pyrimidin-5-yl)thiazol-4-yl)phenyl)acetamide
  参考文献：
  名称：

  Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

  摘要：

  DOI：

  10.1080/00397911.2021.1939383
• 作为产物：
  描述：

  4-氨基-2-(甲基硫代)嘧啶-5-腈 在 吡啶 、 硫化氢 、 三乙胺 作用下， 生成 4-amino-2-(methylthio)pyrimidine-5-carbothioamide
  参考文献：
  名称：

  4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides

  摘要：

  4-氨基-2-取代-5-嘧啶羧酰肟和羧硫酰胺是一种免疫调节剂，可用于治疗免疫系统疾病和紊乱。

  公开号：

  US04323681A1

文献信息

• 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides
  申请人：American Home Products Corporation

  公开号：US04323681A1

  公开（公告）日：1982-04-06

  4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides are immunomodulatory agents useful in the treatment of immune system diseases and disorders.

  4-氨基-2-取代-5-嘧啶羧酰肟和羧硫酰胺是一种免疫调节剂，可用于治疗免疫系统疾病和紊乱。
• AZO DYE
  申请人：Fujifilm Corporation

  公开号：EP1772493B1

  公开（公告）日：2016-07-20
• Azo Dye
  申请人：Ishiwata Yasuhiro

  公开号：US20080027221A1

  公开（公告）日：2008-01-31

  An azo dye represented by the following formula (I): wherein, in formula (I), R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, an aliphatic group, an aryl group, a halogen atom, an acyl group, a cyano group, an acylamino group, an aliphatic oxycarbonyl group, an aryloxycarbonyl group, a carbamoyl group, an aliphatic sulfonyl group, an arylsulfonyl group, a sulfamoyl group, an aliphatic oxycarbonylamino group, an aryloxycarbonylamino group, a sulfo group, a carboxyl group, a carbamoylamino group, a sulfamoylamino group, or an aliphatic- or aromatic-sulfonylamino group, wherein R 1 and R 2 and/or R 3 and R 4 may be combined with each other to form a five- or six-membered aromatic ring or non-aromatic ring; X represents a carbon atom or a nitrogen atom, wherein n is 0 when X is a nitrogen atom and n is 1 when X is a carbon atom; A, B, C, and D each represent a carbon atom or a nitrogen atom, provided that at least one of A, B, C and D represents a nitrogen atom; Y represents a substituent; and m denotes an integer from 0 to 3.
• Use of Peroxide Decomposers Method For the Treatment of a Material Other Than the Human Body
  申请人：Kroll Manfred

  公开号：US20080193397A1

  公开（公告）日：2008-08-14

  The invention relates to the use of compounds with certain sulfur and optionally nitrogen atom-containing structures as peroxide decomposers in cosmetic and pharmaceutical agents for treating the skin. The invention also relates to cosmetic and pharmaceutical agents comprising compounds having such structures.
• US3956326A
  申请人：——

  公开号：US3956326A

  公开（公告）日：1976-05-11