2-(1-methyl-piperidin-2-yl)-1H-benzoimidazole | 51785-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-(1-methyl-piperidin-2-yl)-1H-benzoimidazole
• 英文别名: 2-(1-Methylpiperidin-2-yl)-1H-benzimidazole
• CAS: 51785-25-2
• 化学式: C₁₃H₁₇N₃
• 分子量: 215.298
• InChiKey: KEACLUWMRTYPNZ-UHFFFAOYSA-N

物化性质

• 沸点：
  418.6±38.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻苯二胺 、 1-甲基-2-哌啶甲酸乙酯 、 磷酸 以8%的产率得到
  参考文献：
  名称：

  ADDISON, A. W.;RAO, T. N.;WAHLGREN, C. G., J. HETEROCYCL. CHEM., 1983, 20, N 6, 1481-1484

  摘要：

  DOI：

文献信息

• BENZIMIDAZOLE DERIVATIVES
  申请人：Pfizer Inc.

  公开号：EP2170860B9

  公开（公告）日：2017-02-22
• [EN] CANNABINOID CONJUGATE MOLECULES<br/>[FR] MOLÉCULES CONJUGUÉES DE CANNABINOÏDES
  申请人：DIVERSE BIOTECH INC

  公开号：WO2020263888A1

  公开（公告）日：2020-12-30

  This disclosure provides multifunctional conjugate molecules in which at least one therapeutic agent is covalently attached to a cannabinoid by means of a linker. The disclosed conjugate molecules are designed to deliver therapeutic benefits of components of the conjugate molecules and can be used to treat cancer and other disorders.
• [EN] CONJUGATE MOLECULES<br/>[FR] MOLÉCULES CONJUGUÉES
  申请人：DIVERSE BIOTECH INC

  公开号：WO2021076197A1

  公开（公告）日：2021-04-22

  This disclosure provides multifunctional conjugate molecules comprising a target binding component covalently linked to one or more cannabinoids and/or one or more cannabinoid conjugate components. In some embodiments, the target binding component also is covalently linked to one or more active agent components. The disclosed conjugate molecules are designed to deliver therapeutic benefits of each component of the conjugate molecules and can be used to treat cancer and other disorders.
• ADDISON, A. W.;RAO, T. N.;WAHLGREN, C. G., J. HETEROCYCL. CHEM., 1983, 20, N 6, 1481-1484
  作者：ADDISON, A. W.、RAO, T. N.、WAHLGREN, C. G.

  DOI：——

  日期：——