decanoic acid [4-oxo-2-(2-hydroxyphenyl)-thiazolidin-3-yl]amide | 1316243-30-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: decanoic acid [4-oxo-2-(2-hydroxyphenyl)-thiazolidin-3-yl]amide
• 英文别名: N-[2-(2-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl]decanamide
• CAS: 1316243-30-7
• 化学式: C₁₉H₂₈N₂O₃S
• 分子量: 364.509
• InChiKey: IPOKQGXUAQOPPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  癸酸甲酯 在 一水合肼 、 溶剂黄146 、 zinc(II) chloride 作用下， 以 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 decanoic acid [4-oxo-2-(2-hydroxyphenyl)-thiazolidin-3-yl]amide
  参考文献：
  名称：

  Thiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents

  摘要：

  Starting from capric acid, hydrazone and thiazolidin-4-one derivatives have been synthesized in the present investigation. Decanoic acid hydrazide was reacted appropriately to yield hydrazones, which were then cyclized to yield the corresponding thiazolidin-4-ones. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Anti-inflammatory, analgesic, and hydrogen peroxide-scavenging activity of the title compounds were evaluated. Among synthesized compounds, 2-hydroxyphenyl thiazolidinone with 44.90% inhibition of inflammation was the most potent anti-inflammatory agent. Similarly, 4-methoxybenzylidine hydrazide with 64.90% inhibition of writhing was observed to be the most potent analgesic agent of the synthesized compounds. All the synthesized compounds exhibited potent hydrogen peroxide-scavenging activity.

  DOI：

  10.3109/14756366.2010.535796

文献信息

• Thiazolidin-4-one and hydrazone derivatives of capric acid as possible anti-inflammatory, analgesic and hydrogen peroxide-scavenging agents
  作者：Archana Sharma、Vipin Kumar、Sandeep Jain、Prabodh Chander Sharma

  DOI：10.3109/14756366.2010.535796

  日期：2011.8.1

  Starting from capric acid, hydrazone and thiazolidin-4-one derivatives have been synthesized in the present investigation. Decanoic acid hydrazide was reacted appropriately to yield hydrazones, which were then cyclized to yield the corresponding thiazolidin-4-ones. The structures of the newly synthesized compounds were confirmed by analytical and spectral methods. Anti-inflammatory, analgesic, and hydrogen peroxide-scavenging activity of the title compounds were evaluated. Among synthesized compounds, 2-hydroxyphenyl thiazolidinone with 44.90% inhibition of inflammation was the most potent anti-inflammatory agent. Similarly, 4-methoxybenzylidine hydrazide with 64.90% inhibition of writhing was observed to be the most potent analgesic agent of the synthesized compounds. All the synthesized compounds exhibited potent hydrogen peroxide-scavenging activity.