4-amino-1-dectlpyridinium bromide | 1049722-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-1-dectlpyridinium bromide
• 英文别名: 4-amino-1-decylpyridinium bromide；1-Decylpyridin-1-ium-4-amine;bromide
• CAS: 1049722-94-2
• 化学式: Br*C₁₅H₂₇N₂
• 分子量: 315.297
• InChiKey: XZQDEJNZYKZZER-UHFFFAOYSA-N

物化性质

• 溶解度：
  >47.3 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  4.69
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  27.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氨基吡啶 、 癸基溴 以 丙酮 为溶剂， 反应 12.0h， 以85%的产率得到4-amino-1-dectlpyridinium bromide
  参考文献：
  名称：

  Synthesis, characterization and antimicrobial activity of 4-amino-1-alkyl pyridinium salts

  摘要：

  A series of 4-amino-1-alkyl pyridinium bromide salts (1-10) were synthesized and antimicrobial activity was evaluated by disc diffusion as well as broth macro-dilution method. 4-Amino-1-hexadecylpyridinium bromide (10) which showed good inhibition against Candida albicans and C. glabrata also displayed good germ tube inhibition against C. albicans. Compound 8 shows very low haemolytic activity against human red blood cells. Compound 10 exhibits excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. Inhibition of phospholipase enzyme secretion was also observed against compound 8 to find the possible mode of action.

  DOI：

  10.1007/s00044-011-9578-4

文献信息

• Synthesis, characterization and antimicrobial activity of 4-amino-1-alkyl pyridinium salts
  作者：A. Ilangovan、P. Venkatesan、M. Sundararaman、R. Rajesh Kumar

  DOI：10.1007/s00044-011-9578-4

  日期：2012.6

  A series of 4-amino-1-alkyl pyridinium bromide salts (1-10) were synthesized and antimicrobial activity was evaluated by disc diffusion as well as broth macro-dilution method. 4-Amino-1-hexadecylpyridinium bromide (10) which showed good inhibition against Candida albicans and C. glabrata also displayed good germ tube inhibition against C. albicans. Compound 8 shows very low haemolytic activity against human red blood cells. Compound 10 exhibits excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. Inhibition of phospholipase enzyme secretion was also observed against compound 8 to find the possible mode of action.