4,6-Dichloro-2-(2-phenylethyl)pyrimidine | 1191918-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4,6-Dichloro-2-(2-phenylethyl)pyrimidine
• CAS: 1191918-69-0
• 化学式: C₁₂H₁₀Cl₂N₂
• 分子量: 253.131
• InChiKey: CIVGSRKXNRKXPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,6-Dichloro-2-(2-phenylethyl)pyrimidine 、 (R)-4-Boc-2-甲基哌嗪 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl (R)-4-(6-chloro-2-phenethylpyrimidin-4-yl)-3-methylpiperazine-1-carboxylate
  参考文献：
  名称：

  Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists

  摘要：

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.133
• 作为产物：
  描述：

  4-hydroxy-2-(2-phenylethyl)-1H-pyrimidin-6-one 在 四乙基氯化铵 、 三氯氧磷 作用下， 以 EtCN 为溶剂， 生成 4,6-Dichloro-2-(2-phenylethyl)pyrimidine
  参考文献：
  名称：

  Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists

  摘要：

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.133

文献信息

• Desulfonative photoredox alkylation of <i>N</i>-heteroaryl sulfones – an acid-free approach for substituted heteroarene synthesis
  作者：Zheng-Jun Wang、Shuai Zheng、Jennifer K. Matsui、Zhipeng Lu、Gary A. Molander

  DOI：10.1039/c9sc00776h

  日期：——

  Minisci-type alkylation of electron-deficient heteroarenes has been a pivotal technique for medicinal chemists in the synthesis of drug-like molecules. However, such transformations usually require harsh conditions (e.g., strong acids, stoichiometric amount of oxidants, elevated temperatures, etc.). Herein, by utilizing photoredox catalysis, a highly-selective alkylation method using heteroaryl sulfones

  电子缺陷型杂芳烃的Minisci型烷基化已成为药物化学家合成类药物分子的关键技术。但是，这种转化通常需要苛刻的条件（例如强酸，化学计量的氧化剂，高温等）。本文中，通过利用光氧化还原催化，已经开发了使用杂芳基砜的高选择性烷基化方法，其可以在无酸和氧化还原中性条件下进行。由于这些温和的条件，可以安装具有挑战性但又优先的结构，例如单糖和未保护的仲胺。
• Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists
  作者：Mark D. Andrews、Martin P. Green、Charlotte M.N. Allerton、David V. Batchelor、Julian Blagg、Alan D. Brown、David W. Gordon、Gordon McMurray、Daniel J. Millns、Carly L. Nichols、Lesa Watson

  DOI：10.1016/j.bmcl.2009.07.133

  日期：2009.9

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.