N2-((1r,4r)-4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine | 294647-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N2-((1r,4r)-4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine
• CAS: 294647-35-1
• 化学式: C₂₆H₃₂N₈
• 分子量: 456.594
• InChiKey: BPFHXLYKZFEZRE-MEMLXQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.76
• 重原子数：
  34.0
• 可旋转键数：
  7.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  106.57
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  (4-(吡啶-2-基)苯基)甲胺 、 2-碘代丙烷 、 trans-1,4-Diaminocyclohexane 、 2,6-二氯嘌呤 在 potassium carbonate 作用下， 以 乙醇 、 水 、 二甲基亚砜 为溶剂， 反应 48.0h， 生成 N2-((1r,4r)-4-aminocyclohexyl)-9-isopropyl-N6-(4-(pyridin-2-yl)benzyl)-9H-purine-2,6-diamine
  参考文献：
  名称：

  Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

  摘要：

  C-6 Biarylmethylamino purine derivatives of roscovitine (1) inhibit cyclin dependent kinases and demonstrate potent antiproliferative activity. Replacement of the aryl rings of the C-6 biarylmethylamino group with heterobiaryl rings has provided compounds with significantly improved activity. In particular, derivatives 18g and 9c demonstrated 1000-fold and 1250-fold improvements, respectively, in the growth inhibition of HeLa cells compared to roscovitine (1). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.011

文献信息

• REMOVAL OF SENESCENCE-ASSOCIATED MACROPHAGES
  申请人：EVERON BIOSCIENCES, INC.

  公开号：US20200123127A1

  公开（公告）日：2020-04-23

  In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging organism Normal tissue and/or age-related diseases.